Dopamine function in obsessive—compulsive disorder: Growth hormone response to apomorphine stimulation

1997 ◽  
Vol 42 (10) ◽  
pp. 889-897 ◽  
Author(s):  
Francesca Brambilla ◽  
Laura Bellodi ◽  
Giampaolo Perna ◽  
Cinzia Arancio ◽  
Angelo Bertani
1983 ◽  
Vol 142 (2) ◽  
pp. 184-187 ◽  
Author(s):  
Larry J. Siever ◽  
Thomas R. Insel ◽  
David C. Jimerson ◽  
C. Raymond Lake ◽  
Thomas W. Uhde ◽  
...  

SummaryWe have observed a lesser growth hormone response to intravenous clonidine administration in nine obsessive-compulsive disorder patients meeting research diagnostic criteria than in nine matched controls. The obsessive-compulsive disorder patients had higher plasma free 3-methoxy-4-hydroxyphenylglycol and plasma norepinephrine levels before clonidine than the controls. As blunted growth hormone responses to clonidine are also characteristic of affective disorder patients, these results support other observations of a psychobiologic affinity between these two groups and are also compatible with an association between increased presynaptic noradrenergic activity and decreased post-synaptic receptor responsiveness.


1997 ◽  
Vol 69 (2-3) ◽  
pp. 155-162 ◽  
Author(s):  
Francesca Brambilla ◽  
Giampaolo Perna ◽  
Laura Bellodi ◽  
Cinzia Arancio ◽  
Angelo Bertani ◽  
...  

2006 ◽  
Vol 31 (9) ◽  
pp. 1098-1104 ◽  
Author(s):  
M KLUGE ◽  
P SCHUSSLER ◽  
J WEIKEL ◽  
M DRESLER ◽  
V ZUBER ◽  
...  

1990 ◽  
Vol 13 (4) ◽  
pp. 297-302 ◽  
Author(s):  
Ronit Weizman ◽  
Irit Gil-Ad ◽  
Haggai Hermesh ◽  
Hanan Munitz ◽  
Zvi Laron

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