Growth hormone response to growth hormone-releasing hormone stimulation in obsessive–compulsive disorder

1998 ◽  
Vol 81 (3) ◽  
pp. 293-299 ◽  
Author(s):  
Francesca Brambilla ◽  
Laura Bellodi ◽  
Giampaolo Perna ◽  
Cinzia Arancio ◽  
Angelo Bertani
1983 ◽  
Vol 142 (2) ◽  
pp. 184-187 ◽  
Author(s):  
Larry J. Siever ◽  
Thomas R. Insel ◽  
David C. Jimerson ◽  
C. Raymond Lake ◽  
Thomas W. Uhde ◽  
...  

SummaryWe have observed a lesser growth hormone response to intravenous clonidine administration in nine obsessive-compulsive disorder patients meeting research diagnostic criteria than in nine matched controls. The obsessive-compulsive disorder patients had higher plasma free 3-methoxy-4-hydroxyphenylglycol and plasma norepinephrine levels before clonidine than the controls. As blunted growth hormone responses to clonidine are also characteristic of affective disorder patients, these results support other observations of a psychobiologic affinity between these two groups and are also compatible with an association between increased presynaptic noradrenergic activity and decreased post-synaptic receptor responsiveness.


1990 ◽  
Vol 10 (10) ◽  
pp. 1073-1080
Author(s):  
Santiago Muzzo ◽  
Raquel Burrows ◽  
Jorge Winterer ◽  
Isabel Young ◽  
Saul Malozowski ◽  
...  

1997 ◽  
Vol 42 (10) ◽  
pp. 889-897 ◽  
Author(s):  
Francesca Brambilla ◽  
Laura Bellodi ◽  
Giampaolo Perna ◽  
Cinzia Arancio ◽  
Angelo Bertani

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