Critical evaluation of papers reviewing controlled clinical trials in homoeopathy

1994 ◽  
Vol 83 (03) ◽  
pp. 167-173 ◽  
Author(s):  
D. Melchart ◽  
R. Brandmaier ◽  
F. Eitel ◽  
K. Linde
Keyword(s):  
Clinical Trials ◽  
Quality Assessment ◽  
Clinical Studies ◽  
Critical Evaluation ◽  
Treatment Strategies ◽  
Quality Criteria ◽  
Critical Assessment ◽  
Controlled Clinical Trials

AbstractAn analysis was made of papers reviewing controlled clinical trials designed to assess efficacy of homoeopathic treatment strategies, the aim being to demonstrate selective and critical assessment of such papers. The papers were systematically collected and evaluated for content and quality using predefined criteria, finally comparing the results. 9 of 41 papers considered in detail after screening the literature met the criteria for inclusion in the analysis. Each considered between 22 and 107 trials. 7 papers met 2 or less of the predefined quality criteria, one met 6 and one 8 criteria. Only 1 of the papers allowed full representation and reproducible evaluation of treatment strategies for the controlled clinical studies considered in that paper. The analysis has shown that review papers must clearly specify issues, objectives, methods of literature screening and quality assessment.

Comparison of Melissa with Acyclovir on Recurrent Labial Herpes (A systematic review)

2021 ◽  
Author(s):  
Zahra Golestannejad ◽  
Faezeh Khozeimeh ◽  
Navid Mojtahedi ◽  
Fatemeh Abbasi ◽  
Zahra Seyedmoalemi
Keyword(s):  
Quality Assessment ◽  
Clinical Studies ◽  
Systematic Approach ◽  
Herpes Labialis ◽  
Medical Sciences ◽  
Controlled Clinical Trials ◽  
Melissa Officinalis ◽  
Exclusion Criteria ◽  
Medical Library ◽  
Recurrent Herpes

Introduction: Given the indefinite effect of antinucleoside drugs on the improvement of Recurrent Herpes Labialis, plant medicines such as Melissa officinalis have been proposed as a treatment of choice for these lesions. Clinical studies have reported different and conflicting results for the effect of Melissa on herpes. Hence, using a systematic approach, this study aimed to evaluate the clinical studies on the effect of Melissa on recurrent herpes labialis compared to acyclovir or placebo. Description: The English and Persian controlled clinical trials on the effect of Melissa on recurrent herpes labialis compared to acyclovir or placebo were investigated. Persian databases, including SID, Civilica, Medical Library, and Iranian Medical Sciences Theses and English databases content ProQuest, PubMed Google Scholar, were searched from 1990 to 2018 using a pre-designed strategy. Quality assessment of studies performed using the CONSORT-2010 checklist. The exclusion criteria of this study resemble details of both Persian and English searches/ articles, and eliminating one of them, invitro studies, and studies lacking an acceptable score by the CONSORT checklist. Out of 955 reviewed and evaluated articles from the 2010 consort checklist, 3 articles scored above 7.2 Articles were in English and 1 Article was in Persian. The search results were evaluated by the quality assessment of the recruited studies’ results. Compared to acyclovir and placebo, Melissa was more effective in reducing the lesion pain and size but had no significant effect on decreasing inflammation and erythema. The administration of the drugs did not provide any side effects. Conclusion: Melissa was more effective than Acyclovir and placebo in reducing the lesion pain and size but did not significantly decrease inflammation and erythema.

The Year in Review: Cardiology

2001 ◽  
Vol 14 (1) ◽  
pp. 18-40
Author(s):  
Cynthia A. Sanoski
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Trials ◽  
Cardiac Arrhythmias ◽  
Treatment Strategies ◽  
Review Article ◽  
Controlled Clinical Trials ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
The Past ◽  
Disease States

Overall, the evolution of the management of a broad spectrum of cardiovascular disease states has occurred primarily as a result of randomized, controlled clinical trials that have been conducted and published over time. During the past two years, the results of numerous clinical trials have certainly had a significant impact on the ways in which practitioners have treated conditions such as chronic heart failure, cardiac arrhythmias, ischemic heart disease, dyslipidemias, and hypertension. This review article summarizes the results of several key clinical trials that evaluated various treatment strategies for these five cardiovascular disease states and attempts to provide insight as to how these findings can be incorporated into clinical practice.

Placebo-Controlled Clinical Trials with Ergotamine in the Acute Treatment of Migraine

Cephalalgia ◽  
1993 ◽  
Vol 13 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Carl Dahlöf
Keyword(s):  
Clinical Trials ◽  
Diagnostic Criteria ◽  
Clinical Data ◽  
Clinical Studies ◽  
Trial Design ◽  
Acute Treatment ◽  
Controlled Clinical Trials ◽  
Ihs Criteria

Although oral ergotamine alone or in combination with caffeine is widely used for the acute treatment of migraine, there is little evidence that it is significantly more effective than placebo. There are no placebo-controlled data to support the use of aerosol or suppository formulations. In addition, the recommended doses of ergotamine cannot be justified. Each formulation of ergotamine now should be tested in clinical studies performed according to the IHS criteria for trial design and in migraine patients fulfilling the diagnostic criteria of the IHS. Until these clinical data are available, no dear recommendations can be given for the use of ergotamine in the acute treatment of migraine.

Review of experimental studies in allergy: 1) Clinical studies

1998 ◽  
Vol 87 (02) ◽  
pp. 89-99 ◽  
Author(s):  
Bernard Poitevin
Keyword(s):  
Clinical Trials ◽  
Clinical Studies ◽  
Allergic Conjunctivitis ◽  
Experimental Studies ◽  
Therapeutic Strategies ◽  
Controlled Clinical Trials

AbstractThe incidence of allergic conditions is increasing. The treatment of allergic conditions by homoeopathy is one of the most extensively investigated aspects of clinical homoeopathy. The author reviews the use of isotherapy and other homoeopathic therapeutic strategies in homoeopathy. Open studies of homoeopathic treatment of allergic conjunctivitis, rhinitis, asthma and sensitivity to Cotrimoxazole are discussed. Controlled clinical trials of Galphimia glanca in hayfever and specific isotherapy in hayfever and asthma are discussed and criticised.

A rejoinder to "Psychotherapy research ethics: Continuing the debate on controlled clinical trials."

1987 ◽  
Vol 42 (12) ◽  
pp. 1132-1133
Author(s):  
Stanley D. Imber ◽  
Lawrence M. Glanz ◽  
Irene Elkin ◽  
Stuart M. Sotsky ◽  
Jenny L. Boyer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Research Ethics ◽  
Psychotherapy Research ◽  
Controlled Clinical Trials

A Multivariate Approach to Analyze Ordinal Data Collected in Clinical Trials of Analgesic Agents

1979 ◽  
Vol 18 (03) ◽  
pp. 175-179
Author(s):  
E. Mabubini ◽  
M. Rainisio ◽  
V. Mandelli
Keyword(s):  
Clinical Trials ◽  
Multivariate Analysis ◽  
Analgesic Effect ◽  
Ordinal Data ◽  
Ordinal Scale ◽  
Multivariate Approach ◽  
Controlled Clinical Trials ◽  
Second Stage ◽  
Analgesic Agents ◽  
Relevant Factors

After pointing out the drawbacks of the approach commonly used to analyze the data collected in controlled clinical trials carried out to evaluate the analgesic effect of potential agents, the authors suggest a procedure suitable for analyzing data coded according to an ordinal scale. In the first stage a multivariate analysis is carried out on the codec! data and the projection of each result in the space of the most relevant factors is obtained. In the second stage the whole set of these values is processed by distribution-free tests. The procedure has been applied to data previously published by VENTAITBIDDA et al. [18].

Fluoxetine Not Associated With Increased Violence or Aggression in Controlled Clinical Trials

1992 ◽  
Vol 4 (4) ◽  
pp. 285-295 ◽  
Author(s):  
John Heiligenstein ◽  
Emil Coccaro ◽  
Janet Potvin ◽  
Charles Beasley ◽  
Bruce Dornseif ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Controlled Clinical Trials
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