Comparison of Melissa with Acyclovir on Recurrent Labial Herpes (A systematic review)

2021 ◽  
Author(s):  
Zahra Golestannejad ◽  
Faezeh Khozeimeh ◽  
Navid Mojtahedi ◽  
Fatemeh Abbasi ◽  
Zahra Seyedmoalemi
Keyword(s):  
Quality Assessment ◽  
Clinical Studies ◽  
Systematic Approach ◽  
Herpes Labialis ◽  
Medical Sciences ◽  
Controlled Clinical Trials ◽  
Melissa Officinalis ◽  
Exclusion Criteria ◽  
Medical Library ◽  
Recurrent Herpes

Introduction: Given the indefinite effect of antinucleoside drugs on the improvement of Recurrent Herpes Labialis, plant medicines such as Melissa officinalis have been proposed as a treatment of choice for these lesions. Clinical studies have reported different and conflicting results for the effect of Melissa on herpes. Hence, using a systematic approach, this study aimed to evaluate the clinical studies on the effect of Melissa on recurrent herpes labialis compared to acyclovir or placebo. Description: The English and Persian controlled clinical trials on the effect of Melissa on recurrent herpes labialis compared to acyclovir or placebo were investigated. Persian databases, including SID, Civilica, Medical Library, and Iranian Medical Sciences Theses and English databases content ProQuest, PubMed Google Scholar, were searched from 1990 to 2018 using a pre-designed strategy. Quality assessment of studies performed using the CONSORT-2010 checklist. The exclusion criteria of this study resemble details of both Persian and English searches/ articles, and eliminating one of them, invitro studies, and studies lacking an acceptable score by the CONSORT checklist. Out of 955 reviewed and evaluated articles from the 2010 consort checklist, 3 articles scored above 7.2 Articles were in English and 1 Article was in Persian. The search results were evaluated by the quality assessment of the recruited studies’ results. Compared to acyclovir and placebo, Melissa was more effective in reducing the lesion pain and size but had no significant effect on decreasing inflammation and erythema. The administration of the drugs did not provide any side effects. Conclusion: Melissa was more effective than Acyclovir and placebo in reducing the lesion pain and size but did not significantly decrease inflammation and erythema.

Critical evaluation of papers reviewing controlled clinical trials in homoeopathy

1994 ◽  
Vol 83 (03) ◽  
pp. 167-173 ◽  
Author(s):  
D. Melchart ◽  
R. Brandmaier ◽  
F. Eitel ◽  
K. Linde
Keyword(s):  
Clinical Trials ◽  
Quality Assessment ◽  
Clinical Studies ◽  
Critical Evaluation ◽  
Treatment Strategies ◽  
Quality Criteria ◽  
Critical Assessment ◽  
Controlled Clinical Trials

AbstractAn analysis was made of papers reviewing controlled clinical trials designed to assess efficacy of homoeopathic treatment strategies, the aim being to demonstrate selective and critical assessment of such papers. The papers were systematically collected and evaluated for content and quality using predefined criteria, finally comparing the results. 9 of 41 papers considered in detail after screening the literature met the criteria for inclusion in the analysis. Each considered between 22 and 107 trials. 7 papers met 2 or less of the predefined quality criteria, one met 6 and one 8 criteria. Only 1 of the papers allowed full representation and reproducible evaluation of treatment strategies for the controlled clinical studies considered in that paper. The analysis has shown that review papers must clearly specify issues, objectives, methods of literature screening and quality assessment.

Prediction of the Incidence of Recurrent Herpes Labialis and Systemic Illness from Psychological Measurements

1973 ◽  
Vol 52 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Aaron Honori Katcher ◽  
Vernon Brightman ◽  
Lester Luborsky ◽  
Irwin Ship
Keyword(s):  
Herpes Labialis ◽  
Recurrent Herpes

Acyclovir Lauriad®: a muco-adhesive buccal tablet for the treatment of recurrent herpes labialis

2014 ◽  
Vol 12 (3) ◽  
pp. 283-287 ◽  
Author(s):  
Christopher Downing ◽  
Jonathan Moayyad ◽  
Aparna Tamirisa ◽  
Stephen Tyring
Keyword(s):  
Herpes Labialis ◽  
Buccal Tablet ◽  
Recurrent Herpes

scholarly journals Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals

2020 ◽  
Author(s):  
Zahra Ranjbar ◽  
Maryam Zahed ◽  
Mohammad Ali Ranjbar ◽  
Zahra Shirmardan
Keyword(s):  
Healthy Subjects ◽  
Serum Zinc ◽  
Zinc Level ◽  
Therapeutic Effects ◽  
Herpes Labialis ◽  
Healthy Individuals ◽  
Serum Zinc Level ◽  
Significant Difference ◽  
Recurrent Herpes ◽  
History Of

Abstract Background: Recurrent herpes labialis (RHL) is one of the most common recurrent infective vesiculoulcerative lesions. Topical and systemic administration of Zinc compounds has been found to have preventive and therapeutic effects. The purpose of this article is to evaluate the serum level of zinc in patients with RHL and healthy individuals. Methods: This cross-sectional study was performed on 43 patients with the history of recurrent herpers labialis and 42 healthy subjects with no history of the lesion. Blood samples were taken and serum zinc level was measured. Chi-Square test was used to compare the qualitative relationships and to compare the quantitative relationships independent T-test was used. To observe the relationship of quantitative factors including serum zinc level, the number of relapses and recovery rates correlation test was taken. Results: The results show that serum zinc level has no significant difference in healthy subjects and patients (p> 0.05). Also, zinc level was not related to age and sex factors and frequency of relapse (P> 0.05). But surprisingly in the patients group, there was a significant relationship between zinc level and recovery period. As the serum zinc level was lower, the duration of recovery was significantly higher (p =0.009). Conclusion: The results of this study indicate that zinc deficiency is a risk factor for increasing the duration of herpes labialis lesions. Therefore, the evaluation of serum zinc level in subjects with recurrent herpes labialis and subsequent administration of zinc is recommended in such patients.

Do sunscreen prevent recurrent Herpes labialis in summer?

2018 ◽  
Vol 30 (2) ◽  
pp. 179-182 ◽  
Author(s):  
Vittorio Mazzarello ◽  
Marco Ferrari ◽  
Gabriella Piu ◽  
Valeria Pomponi ◽  
Giuliana Solinas
Keyword(s):  
Herpes Labialis ◽  
Recurrent Herpes
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