Interleukin-1β, interleukin-6, tumour necrosis factor-α and interferon-γ released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes

2003 ◽  
Vol 473 (2-3) ◽  
pp. 197-206 ◽  
Author(s):  
Anne-Marie Bleau ◽  
Patrick Maurel ◽  
Vincent Pichette ◽  
François Leblond ◽  
Patrick du Souich
1998 ◽  
Vol 62 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Irina A Kostanyan ◽  
Rosa I Nurieva ◽  
Elena V Navolotskaya ◽  
Maria V Astapova ◽  
Svetlana M Dranitsina ◽  
...  

1994 ◽  
Vol 30 (2) ◽  
pp. 162-167 ◽  
Author(s):  
Christine Dosquet ◽  
Antoine Schaetz ◽  
Claire Faucher ◽  
Eric Lepage ◽  
Jean-Luc Wautier ◽  
...  

1990 ◽  
Vol 123 (5) ◽  
pp. 476-480 ◽  
Author(s):  
Masaaki Yamaguchi ◽  
Yasuhiro Yoshimoto ◽  
Hiroko Komura ◽  
Koji Koike ◽  
Noboru Matsuzaki ◽  
...  

Abstract. The abilities of recombinant human interleukin 1β and tumour necrosis factor α to induce release of GnRH and interleukin 6 from primary culture of rat hypothalamic cells were examined. The effect of estradiol on the release of interleukin 6 by these cells was also tested. Both interleukin 1β and tumour necrosis factor α caused significant stimulation of GnRH secretion from the hypothalamic cells within 5 min. The hypothalamic cells secreted interleukin 6 spontaneously, and their secretion over 24 h was stimulated dose-dependently by interleukin 1β, tumour necrosis factor α and estradiol. These results suggest that interleukin 1β and tumour necrosis factor α stimulate the secretions of GnRH and interleukin 6 in the hypothalamus, and that these cytokines may be involved in the mechanism of GnRH secretion in the hypothalamus.


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