Comparison of relative potencies of i.v. and i.c.v. administered 8-OH-DPAT gives evidence of different sites of action for hypothermia, lower lip retraction and tail flicks

SummaryThree mucopolysaccharides (MPS) used in the treatment of degenerative joint disease were compared to heparin to establish their relative potencies on 3 coagulation tests, the aPTT, the antifactor X a activity and the dilute thrombin time. One of the compounds, Arteparon®, was one fourth as potent as heparin on the aPTT, but had little or no influence on the 2 other tests. Further in vitro studies suggested that Arteparon® acted at a higher level than factor Xa generation in the intrinsic amplification system and that its effect was independent of antithrombin III. In vivo administration of Arteparon® confirmed its anticoagulant properties, which raises the question of the clinical use of this MPS.

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The Extended Transoral Approach to the Skull Base and Cervical Spine via a Median Splitting of the Lower Lip, Jaw, Floor of Mouth, Tongue, Epiglottis, and Larynx to Facilitate Resection and Plastic Reconstruction, Featuring the Chordoma and Its Recurrences

Skull Base ◽

10.1055/s-2007-983994 ◽

2007 ◽

Vol 17 (S 1) ◽

Author(s):

R. Schmelzle ◽

F. Blake ◽

R. Melcher ◽

L. Li ◽

J. Harms

Keyword(s):

Cervical Spine ◽

Skull Base ◽

Transoral Approach ◽

Lower Lip ◽

Floor Of Mouth ◽

Plastic Reconstruction

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A Case of Solitary Neurofibroma of the Lower Lip

Korean Journal of Otorhinolaryngology - Head and Neck Surgery ◽

10.3342/kjorl-hns.2014.57.5.333 ◽

2014 ◽

Vol 57 (5) ◽

pp. 333 ◽

Cited By ~ 1

Author(s):

So-Hee Choi ◽

Do Hyun Kim ◽

Bo-Young Kim

Keyword(s):

Lower Lip ◽

Solitary Neurofibroma

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METABOLISM AND MODE OF ACTION OF ANDROGENS IN TARGET TISSUES OF MALE RATS

Acta Endocrinologica ◽

10.1530/acta.0.0690165 ◽

1972 ◽

Vol 69 (1) ◽

pp. 165-173 ◽

Cited By ~ 9

Author(s):

H. Schmidt ◽

I. Noack ◽

K. D. Voigt

Keyword(s):

Cell Proliferation ◽

Cell Metabolism ◽

Seminal Vesicles ◽

Male Rats ◽

Ventral Prostate ◽

Nucleic Acid Content ◽

The Difference ◽

Independent Effects ◽

Sites Of Action ◽

Peripheral Metabolism

ABSTRACT The effect of testosterone and 5α-dihydrotestosterone on protein and nucleic acid content as well as on the activities of some enzymes has been studied in the ventral prostate and the seminal vesicles of immature castrated rats. Both androgens were given intraperitoneally in doses of 1 mg daily for one or three days the rats were sacrificed one day after the last injection. In the prostate it was found that 5α-dihydrotestosterone had a greater effect on DNA increase, i. e. cell proliferation than testosterone, whereas cell metabolism was stimulated by the two androgens to nearly the same extent. In the seminal vesicles a single dose led to the same results as had been obtained in the prostate, i. e. a greater cell proliferative action of 5α-dihydrotestosterone and an equal stimulation of cell metabolism by testosterone and 5α-dihydrotestosterone was also observed. When three doses of the two androgens were given, cell proliferation as well as cell metabolism in the seminal vesicles were significantly more increased after 5α-dihydrotestosterone than after testosterone. The difference of action after systemic administration of the two androgens is explained by their different accumulation and by their different peripheral metabolism in the target tissues. From the partly independent effects of various androgens on cell proliferation and cell metabolism the conclusion may be drawn that there exist at least two intracellular sites of action.

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COMPARATIVE ACTION OF VARIOUS OESTROGENIC COMPOUNDS ON MOUSE VAGINAL SIALIC ACIDS (II)

Acta Endocrinologica ◽

10.1530/acta.0.0620663 ◽

1969 ◽

Vol 62 (4) ◽

pp. 663-670 ◽

Cited By ~ 8

Author(s):

Lars Carlborg

Keyword(s):

Sialic Acid ◽

Response Curve ◽

Sialic Acids ◽

Clear Cut ◽

Suitable Parameter ◽

Sufficient Degree ◽

Comparative Action ◽

Relative Potencies ◽

Good Agreement

ABSTRACT Oestrogens administered in lower doses than necessary to induce full cornification of the mouse vagina induce mucification. It was shown previously that the degree of mucification could be estimated by quantitative determination of sialic acids. A suitable parameter for oestrogen assay was the measurement of vaginal sialic acid concentration which exhibited a clear cut dose response curve. Eleven assays of various oestrogens were performed with this method. Their estimated relative potencies were in good agreement with other routine oestrogen assays. A statistically sufficient degree of precision was found. The sensitivity was of the same order, or slightly higher, than the Allen-Doisy test.

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HUMAN URINARY GONADOTROPHINS ASSAYED BY DIFFERENT RESPONSES IN THE SAME ANIMAL

Acta Endocrinologica ◽

10.1530/acta.0.xxxiv0375 ◽

1960 ◽

Vol XXXIV (III) ◽

pp. 375-389 ◽

Cited By ~ 1

Author(s):

P. S. Brown

Keyword(s):

Postmenopausal Women ◽

Ovarian Response ◽

The Other ◽

Relative Potency ◽

Vaginal Opening ◽

Serial Sections ◽

Immature Female ◽

Female Mice ◽

Marked Disparity ◽

Relative Potencies

ABSTRACT Selected human urinary gonadotrophins were assayed against one another using various measures of response in the same immature female mice. Intact or hypophysectomized animals were used and in some experiments the results of hypophysectomy were checked in complete serial sections. Extracts from the urine of two subjects with Turner's syndrome were compared. In intact mice, the relative potency judged by the ovarian response differed from that shown by the uterine response and the 95 % fiducial limits of the two estimates did not overlap. When the mice were hypophysectomized, one extract became much less potent while the other did not. Similar differences were shown in the response of intact mice to urinary extracts from two subjects with Klinefelter's syndrome. There was a marked disparity between the relative potencies shown by the uterine response and by the incidence of vaginal opening. Similar differences were not shown between the responses to different extracts from the urine of normal postmenopausal women, but these extracts were known to differ little in quality. The results are interpreted in terms of qualitative differences between human urinary gonadotrophins.

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