Neuroimaging of aging and estrogen effects on central nervous system physiology

2001 ◽  
Vol 76 (4) ◽  
pp. 651-659 ◽  
Author(s):  
Yolanda R Smith ◽  
Jon-Kar Zubieta
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
System Physiology ◽  
Estrogen Effects

scholarly journals Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol

Neurosurgery ◽  
2017 ◽  
Vol 82 (6) ◽  
pp. 770-780 ◽  
Author(s):  
Joao Prola Netto ◽  
Jeffrey Iliff ◽  
Danica Stanimirovic ◽  
Kenneth A Krohn ◽  
Bronwyn Hamilton ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Imaging Techniques ◽  
Neurovascular Unit ◽  
Iron Oxide Nanoparticle ◽  
Advanced Imaging ◽  
Clinical Imaging ◽  
Oxide Nanoparticle ◽  
System Physiology ◽  
Parenchymal Cells

Abstract Physiological and pathological processes that increase or decrease the central nervous system's need for nutrients and oxygen via changes in local blood supply act primarily at the level of the neurovascular unit (NVU). The NVU consists of endothelial cells, associated blood–brain barrier tight junctions, basal lamina, pericytes, and parenchymal cells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essential for interpretation of central nervous system physiology and pathology as revealed by conventional and advanced imaging techniques. This article reviews current strategies for interrogating the NVU, focusing on vascular permeability, blood volume, and functional imaging, as assessed by ferumoxytol an iron oxide nanoparticle.

scholarly journals Central nervous system physiology

2021 ◽  
Author(s):  
John Rothwell ◽  
Andrea Antal ◽  
David Burke ◽  
Antony Carlsen ◽  
Dejan Georgiev ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
System Physiology

scholarly journals Tissue plasminogen activator in central nervous system physiology and pathology

2005 ◽  
Vol 93 (04) ◽  
pp. 655-660 ◽  
Author(s):  
Jerry Melchor ◽  
Sidney Strickland
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Neuronal Degeneration ◽  
Fibrin Clot ◽  
Proteolytic Cascade ◽  
Tissue Plasminogen ◽  
System Physiology ◽  
The Brain

SummaryAlthough conventionally associated with fibrin clot degradation, recent work has uncovered new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central nervous system physiology and pathology. This extracellular proteolytic cascade has been shown to have roles in learning and memory, stress, neuronal degeneration, addiction and Alzheimer’s disease. The current review considers the different ways tPA functions in the brain.

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