Introduction. Infertility affects 15-17% of reproductive age couples in our
country, and 10-15% of couples worldwide. The aim of this paper was to
present results and experience gained after the first 1000 cycles of the
national In Vitro Fertilization (IVF) program, to offer professional standard
of work in our country and to compare it with results obtained in Europe and
worldwide. Material and methods. The study prospectively included 1000 women
who had undergone national In Vitro Fertilization program from October 2006
until November 2009 at the Department of Gynecology and Obstetrics, Clinical
Center of Vojvodina, Novi Sad. Results. The analysis included 1000 in vitro
fertilization cycles. Male factor infertility was the leading cause (56.9%)
followed by tubal factor (45.9%). The classic method of in vitro
fertilization constituted 72.3% of all cycles, while intracytoplasmic sperm
injection (ICSI) method was used in 27.7% of all cycles. The average number
of embryos transferred was 2.67. The cycle cancellation rate was 14.10% and
the aspiration rate was 94.40%. The clinical pregnancy and live birth rate
were 33.41% and 26.78% per embryo transfer, respectively. Discussion and
conclusion. The results in our study showed that in our setting there are far
less intracytoplasmic sperm injection cycles compared with the European
average of 66.5% of all fresh cycles, and that we transferred more embryos on
average. Our success rates are comparable with those in other European
countries where the clinical pregnancy rates per aspiration and per transfer
for in vitro fertilization were 29 and 32.4%, respectively in the period of
observation. For intracytoplasmic sperm injection, the corresponding rates
were 29.9 and 33%.
Andrology: Classification of male factor infertility relevant to in-vitro fertilization insemination strategies using mannose ligands, acrosome status and anti-cytoskeletal antibodies
