Utility of perinuclear anti-neutrophil cytoplasmic antibodies (pANCA), anti-saccharomyces cerevisiae (ASCA), and anti-pancreatic antibodies (APA) as serologic markers in a population based cohort of patients with Crohn's disease (CD) and ulcerative colitis (UC)

Summary Background: There is an impression mostly from specialty clinics that patients with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolic disorders. Our aim was to determine the incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) from a population-based database of IBD patients and, to compare the incidence rates to that of an age, gender and geographically matched population control group. Methods: IBD patients identified from the administrative claims data of the universal provincial insurance plan of Manitoba were matched 1:10 to randomly selected members of the general population without IBD by year, age, gender, and postal area of residence using Manitoba Health’s population registry. The incidence of hospitalization for DVT and PE was calculated from hospital discharge abstracts using ICD-9-CM codes 451.1, 453.x for DVT and 415.1x for PE. Rates were calculated based on person-years of follow-up for 1984-1997. Comparisons to the population cohort yielded age-adjusted incidence rate ratios (IRR). Rates were calculated based on person-years of follow-up (Crohn’s disease = 21,340, ulcerative colitis = 19,665) for 1984-1997. Results: In Crohn’s disease the incidence rate of DVT was 31.4/10,000 person-years and of PE was 10.3/10,000 person-years. In ulcerative colitis the incidence rates were 30.0/10,000 person-years for DVT and 19.8/10,000 person-years for PE. The IRR was 4.7 (95% CI, 3.5-6.3) for DVT and 2.9 (1.8-4.7) for PE in Crohn’s disease and 2.8 (2.1-3.7) for DVT and 3.6 (2.5-5.2) for PE, in ulcerative colitis. There were no gender differences for IRR. The highest rates of DVT and PE were seen among patients over 60 years old; however the highest IRR for these events were among patients less than 40 years. Conclusion: IBD patients have a threefold increased risk of developing DVT or PE.

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THU0661 RISK OF PSORIASIS, CROHN’S DISEASE, ULCERATIVE COLITIS AND ANKYLOSING SPONDYLITIS IN PATIENTS WITH UVEITIS: A NATIONWIDE, POPULATION-BASED COHORT STUDY

10.1136/annrheumdis-2019-eular.361 ◽

2019 ◽

Author(s):

Hsin-Hua Chen ◽

Tsu-Yi Hsieh ◽

Ching-Heng Lin ◽

Yi-Ming Chen ◽

Kuo-Lung Lai ◽

...

Keyword(s):

Ulcerative Colitis ◽

Cohort Study ◽

Crohn’S Disease ◽

Ankylosing Spondylitis ◽

Crohn's Disease ◽

Population Based

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P797 Crohn’s disease and ulcerative colitis was associated with different lipid profile disorders: a nationwide population-based study

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjy222.921 ◽

2019 ◽

Vol 13 (Supplement_1) ◽

pp. S521-S521

Author(s):

H Soh ◽

J Chun ◽

K Han ◽

S Park ◽

E A Kang ◽

...

Keyword(s):

Ulcerative Colitis ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Lipid Profile ◽

Population Based ◽

Population Based Study

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Mortality in ulcerative colitis and Crohn's disease. A population-based study in Finland

Journal of Crohn s and Colitis ◽

10.1016/j.crohns.2011.10.009 ◽

2012 ◽

Vol 6 (5) ◽

pp. 524-528 ◽

Cited By ~ 30

Author(s):

Pia Manninen ◽

Anna-Liisa Karvonen ◽

Heini Huhtala ◽

Martin Rasmussen ◽

Maarit Salo ◽

...

Keyword(s):

Ulcerative Colitis ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Population Based ◽

Population Based Study

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Familial aggregation in Crohn's disease and ulcerative colitis in a Norwegian population-based cohort followed for ten years

Journal of Crohn s and Colitis ◽

10.1016/j.crohns.2008.11.002 ◽

2009 ◽

Vol 3 (2) ◽

pp. 92-99 ◽

Cited By ~ 24

Author(s):

May-Bente Bengtson ◽

Camilla Solberg ◽

Geir Aamodt ◽

Jostein Sauar ◽

Jørgen Jahnsen ◽

...

Keyword(s):

Ulcerative Colitis ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Familial Aggregation ◽

Population Based ◽

Norwegian Population

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Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role

Gut ◽

10.1136/gut.42.6.788 ◽

1998 ◽

Vol 42 (6) ◽

pp. 788-791 ◽

Cited By ~ 387

Author(s):

J-F Quinton ◽

B Sendid ◽

D Reumaux ◽

P Duthilleul ◽

A Cortot ◽

...

Keyword(s):

Saccharomyces Cerevisiae ◽

Ulcerative Colitis ◽

Inflammatory Bowel Disease ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Positive Predictive Value ◽

Bowel Disease ◽

Inflammatory Bowel ◽

Sensitivity Specificity ◽

Antineutrophil Cytoplasmic Autoantibodies

Background—Perinuclear antineutrophil cytoplasmic autoantibodies (pANCA) are a well recognised marker for ulcerative colitis. Antibodies to oligomannosidic epitopes of the yeastSaccharomyces cerevisiae (ASCA) are a new marker associated with Crohn’s disease.Aims—To assess the value of detecting pANCA and/or ASCA for the diagnosis of ulcerative colitis and Crohn’s disease.Methods—Serum samples were obtained from 100 patients with Crohn’s disease, 101 patients with ulcerative colitis, 27 patients with other miscellaneous diarrhoeal illnesses, and 163 healthy controls. Determination of pANCA and ASCA was performed using the standardised indirect immunofluorescence technique and an ELISA, respectively.Results—The combination of a positive pANCA test and a negative ASCA test yielded a sensitivity, specificity, and positive predictive value of 57%, 97%, and 92.5% respectively for ulcerative colitis. The combination of a positive ASCA test and a negative pANCA test yielded a sensitivity, specificity, and positive predictive value of 49%, 97%, and 96% respectively for Crohn’s disease. Among patients with miscellaneous non-inflammatory bowel disorders, three were ASCA positive and two were pANCA positive. One control was ASCA positive. The presence of ASCA in patients with Crohn’s disease was associated with small bowel involvement.Conclusion—ASCA and pANCA are strongly associated with Crohn’s disease and ulcerative colitis, respectively. Combination of both tests could help the diagnosis of inflammatory bowel disease.

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