In vitro study of photodynamic diagnosis (PDD) with 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PPIX): Differences in PPIX-metabolism determine tumor-selective fluorescence

2000 ◽  
Vol 118 (4) ◽  
pp. A277
Author(s):  
Rene C. Krieg ◽  
Joachim Rauch ◽  
Esther Endlicher ◽  
Juergen Schoelmerich ◽  
Ferdinand Hofstaedter ◽  
...  
Keyword(s):  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
In Vitro Study ◽  
Vitro Study ◽  
Photodynamic Diagnosis ◽  
Tumor Selective

In Vitro Study of Biosynthesis of Protoporphyrin IX Induced By δ-Aminolevulinic Acid in Normal and Cancerous Cells of the Human Cervix

1999 ◽  
Vol 30 (3) ◽  
pp. 163-170 ◽  
Author(s):  
Eva Ramón Gallegos ◽  
Irma DeLeón Rodrı́guez ◽  
Lydia Alejandra Martı́nez Guzmán ◽  
Aura Judith Pérez Zapata
Keyword(s):  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
In Vitro Study ◽  
Vitro Study ◽  
Cancerous Cells ◽  
Human Cervix

scholarly journals Systematic Review and Meta-Analysis of In Vitro Anti-Human Cancer Experiments Investigating the Use of 5-Aminolevulinic Acid (5-ALA) for Photodynamic Therapy

2021 ◽  
Vol 14 (3) ◽  
pp. 229
Author(s):  
Yo Shinoda ◽  
Daitetsu Kato ◽  
Ryosuke Ando ◽  
Hikaru Endo ◽  
Tsutomu Takahashi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Human Cancer ◽  
Meta Analysis ◽  
Protoporphyrin Ix ◽  
Cell Types ◽  
Amino Acid Derivative ◽  
Photodynamic Diagnosis

5-Aminolevulinic acid (5-ALA) is an amino acid derivative and a precursor of protoporphyrin IX (PpIX). The photophysical feature of PpIX is clinically used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These clinical applications are potentially based on in vitro cell culture experiments. Thus, conducting a systematic review and meta-analysis of in vitro 5-ALA PDT experiments is meaningful and may provide opportunities to consider future perspectives in this field. We conducted a systematic literature search in PubMed to summarize the in vitro 5-ALA PDT experiments and calculated the effectiveness of 5-ALA PDT for several cancer cell types. In total, 412 articles were identified, and 77 were extracted based on our inclusion criteria. The calculated effectiveness of 5-ALA PDT was statistically analyzed, which revealed a tendency of cancer-classification-dependent sensitivity to 5-ALA PDT, and stomach cancer was significantly more sensitive to 5-ALA PDT compared with cancers of different origins. Based on our analysis, we suggest a standardized in vitro experimental protocol for 5-ALA PDT.

Intracellular Localization is a Cofactor for the Phototoxicity of Protoporphyrin IX in the Gastrointestinal Tract: In Vitro Study¶†

2003 ◽  
Vol 78 (4) ◽  
pp. 393 ◽  
Author(s):  
René C. Krieg ◽  
Helmut Messmann ◽  
Klaus Schlottmann ◽  
Esther Endlicher ◽  
Stephan Seeger ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Intracellular Localization ◽  
Protoporphyrin Ix ◽  
In Vitro Study ◽  
Vitro Study

scholarly journals Aminolevulinic Acid-Mediated Photodynamic Therapy of Human Meningioma: An in Vitro Study on Primary Cell Lines

2015 ◽  
Vol 16 (12) ◽  
pp. 9936-9948 ◽  
Author(s):  
Mustafa El-Khatib ◽  
Carolin Tepe ◽  
Brigitte Senger ◽  
Maxine Dibué-Adjei ◽  
Markus Riemenschneider ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Lines ◽  
Aminolevulinic Acid ◽  
In Vitro Study ◽  
Vitro Study ◽  
Primary Cell ◽  
Human Meningioma ◽  
Primary Cell Lines

An in vitro study on the photosensitivity of 5-aminolevulinic acid conjugated gold nanoparticles

2013 ◽  
Vol 10 (4) ◽  
pp. 382-388 ◽  
Author(s):  
Zahra Mohammadi ◽  
Ameneh Sazgarnia ◽  
Omid Rajabi ◽  
Samaneh Soudmand ◽  
Habibollah Esmaily ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Aminolevulinic Acid ◽  
In Vitro Study ◽  
Vitro Study

In-vitro study on ALA-induced endogenous protoporphyrin IX as photosensitizer for photodynamic tumor diagnosis and therapy

1998 ◽  
Author(s):  
K. Ueberriegler ◽  
D. Fiedler ◽  
Thomas Verwanger ◽  
Gerlinde Schnitzhofer ◽  
E. Banieghbal ◽  
...  
Keyword(s):  
Protoporphyrin Ix ◽  
In Vitro Study ◽  
Tumor Diagnosis ◽  
Vitro Study ◽  
Diagnosis And Therapy
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