Enhanced gastroprotective and anti-ulcerogenic activities in rats of a new class of proton pump inhibitor containing nitrosothiol nitric oxide donor

2001 ◽  
Vol 120 (5) ◽  
pp. A144-A145
Author(s):  
J SAHA ◽  
T WANG ◽  
R STEWART ◽  
M TROCHA ◽  
M SHUMWAY ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Nitric Oxide Donor ◽  
New Class

Enhanced gastroprotective and anti-ulcerogenic activities in rats of a new class of proton pump inhibitor containing nitrosothiol nitric oxide donor

2001 ◽  
Vol 120 (5) ◽  
pp. A144-A145 ◽  
Author(s):  
Joy K. Saha ◽  
Tiansheng Wang ◽  
Richardson Stewart ◽  
Mark Trocha ◽  
Mathew Shumway ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Nitric Oxide Donor ◽  
New Class

O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

2017 ◽  
Vol 53 (36) ◽  
pp. 5059-5062 ◽  
Author(s):  
Chengfeng Bai ◽  
Rongfang Xue ◽  
Jianbing Wu ◽  
Tian Lv ◽  
Xiaojun Luo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Donor ◽  
Nitric Oxide Donors ◽  
New Class

3c, a new nitric oxide donor activatable by GSH/GSTπ, exhibits both anti-proliferative and anti-metastatic activities against melanoma.

scholarly journals Omeprazole Antagonizes Virulence and Inflammation in Salmonella enterica-Infected RAW264.7 Cells

2009 ◽  
Vol 53 (6) ◽  
pp. 2402-2409 ◽  
Author(s):  
Speranta Puiac ◽  
Aurel Negrea ◽  
Agneta Richter-Dahlfors ◽  
Laura Plant ◽  
Mikael Rhen
Keyword(s):  
Nitric Oxide ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Salmonella Enterica ◽  
Host Cells ◽  
Raw264.7 Cells ◽  
Nitric Oxide Production ◽  
Intracellular Replication ◽  
Oxide Production

ABSTRACT The proton pump inhibitor omeprazole reduced the intracellular replication of Salmonella enterica serovar Typhimurium in RAW264.7 cells without affecting bacterial growth in vitro or the viability of the host cells. The mechanism was bacteriostatic and interfered with replication mediated by the virulence-associated SPI2 type III secretion system. The proton pump inhibitor bafilomycin A1, in contrast, mediated killing of intracellular bacteria and imposed a marked cytotoxicity on RAW264.7 cells. The two compounds also differentially affected the proinflammatory responses of the infected cells. Bafilomycin A1 enhanced nitric oxide production, whereas omeprazole delayed IκB degradation and blocked nitric oxide production and the secretion of proinflammatory cytokines. These results imply that omeprazole can be used to block the virulence factor-mediated intracellular replication of S. Typhimurium, and that its mechanism of growth inhibition is different from that mediated by bafilomycin A1.

scholarly journals Genetic toxicology and preliminaryin vivostudies of nitric oxide donor tocopherol analogs as potential new class of antiatherogenic agents

2011 ◽  
Vol 34 (3) ◽  
pp. 285-293 ◽  
Author(s):  
Mauricio Cabrera ◽  
Gloria V. López ◽  
Luis E. Gómez ◽  
Martín Breijo ◽  
Cristina Pintos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Donor ◽  
Genetic Toxicology ◽  
New Class
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