842 Cancer-Derived Myofibroblasts Promote Tumor Initiating Cell Expansion in Colorectal Cancer

2009 ◽  
Vol 136 (5) ◽  
pp. A-128
Author(s):  
Randy C. Mifflin ◽  
Iryna V. Pinchuk ◽  
Jamal I. Saada ◽  
Sahil Mittal ◽  
Suimin Qiu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Expansion ◽  
Tumor Initiating Cell

scholarly journals Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor

2020 ◽  
Vol 123 (6) ◽  
pp. 955-964
Author(s):  
Kazuya Iwamoto ◽  
Hidekazu Takahashi ◽  
Daisuke Okuzaki ◽  
Hideo Osawa ◽  
Takayuki Ogino ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prostaglandin E2 ◽  
Cell Expansion ◽  
Stem Cell Expansion ◽  
Prostaglandin E2 Receptor

scholarly journals Abstract 2893: IGF2 is essential for tumor initiating cell activity in human colorectal cancer

2017 ◽  
Author(s):  
Taronish D. Dubash ◽  
Christine Siegl ◽  
Sebastian M. Dieter ◽  
Joachim Weischenfeldt ◽  
Alexandros P. Drainas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Activity ◽  
Human Colorectal Cancer ◽  
Tumor Initiating Cell

microRNA-454 promotes liver tumor-initiating cell expansion by regulating SOCS6

2020 ◽  
Vol 390 (1) ◽  
pp. 111955 ◽  
Author(s):  
Zhengqing Lei ◽  
Xuewu Tang ◽  
Anfeng Si ◽  
Pinghua Yang ◽  
Lihong Wang ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Cell Expansion ◽  
Tumor Initiating Cell

scholarly journals Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

2015 ◽  
Vol 149 (7) ◽  
pp. 1884-1895.e4 ◽  
Author(s):  
Dingzhi Wang ◽  
Lingchen Fu ◽  
Haiyan Sun ◽  
Lixia Guo ◽  
Raymond N. DuBois
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prostaglandin E2 ◽  
Cell Expansion ◽  
Stem Cell Expansion

scholarly journals IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts

2013 ◽  
Vol 34 (11) ◽  
pp. 2647-2654 ◽  
Author(s):  
Kathryn E. Hamilton ◽  
Felicite K. Noubissi ◽  
Prateek S. Katti ◽  
Christopher M. Hahn ◽  
Sonya R. Davey ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Cell Phenotype ◽  
Tumor Initiating Cell

scholarly journals Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1097
Author(s):  
Martina K. Zowada ◽  
Stephan M. Tirier ◽  
Sebastian M. Dieter ◽  
Teresa G. Krieger ◽  
Ava Oberlack ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Differentiation ◽  
Single Cell ◽  
Therapy Resistance ◽  
Specific Expression ◽  
Cell Type Specific Expression ◽  
Functional States ◽  
Cell Subpopulations ◽  
Patient Prognosis ◽  
Tumor Initiating Cell

Intra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell RNA-sequencing of patient-derived CRC models to decipher distinct cell subpopulations based on their transcriptional profiles. Cell type-specific expression modules of stem-like, transit amplifying-like, and differentiated CRC cells resemble differentiation states of normal intestinal epithelial cells. Strikingly, identified subpopulations differ in proliferative activity and metabolic state. In summary, we here show at single-cell resolution that transcriptional heterogeneity identifies functional states during TIC differentiation. Furthermore, identified expression signatures are linked to patient prognosis. Targeting transcriptional states associated to cancer cell differentiation might unravel novel vulnerabilities in human CRC.

Tu2003 Cancer Stem Cell Expansion via Hes1 Activation Induced by IL6/Il8 From Myofibroblast in Colorectal Cancer Microenvironment

2015 ◽  
Vol 148 (4) ◽  
pp. S-957
Author(s):  
Ji-Hee Kwon ◽  
Bun Kim ◽  
Kyoung Jin Lee ◽  
Soo Jung Park ◽  
Sung Pil Hong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Expansion ◽  
Cancer Microenvironment ◽  
Stem Cell Expansion
Sign in / Sign up

Export Citation Format

Share Document