T1778 Reciprocal Modulation of Smooth Muscle Cell Contractility in TH1 and Th2 Dominant Environments Using Murine Model of Early Post Inflammatory Gut Dysfunction

2009 ◽  
Vol 136 (5) ◽  
pp. A-578 ◽  
Author(s):  
Hiroyuki Murao ◽  
Hirotada Akiho ◽  
Takahiro Mizutani ◽  
Mariko Yamada ◽  
Noriko Tokunaga ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Murine Model ◽  
Cell Contractility ◽  
Gut Dysfunction ◽  
Th1 And Th2

scholarly journals Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Natalija Bogunovic ◽  
Jorn P. Meekel ◽  
Dimitra Micha ◽  
Jan D. Blankensteijn ◽  
Peter L. Hordijk ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Contractility ◽  
Abdominal Aortic ◽  
Novel Concept

scholarly journals 557: Progesterone decreases human cervical smooth muscle cell contractility

2019 ◽  
Vol 220 (1) ◽  
pp. S372
Author(s):  
Joy Vink ◽  
Sudip Dahal ◽  
Hongyu Li ◽  
Mirella Mourad ◽  
Chioma Ndubisi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Contractility

Effect of Tissue Dehydration on Smooth Muscle Cell Contractility, Collagen Matrix Structure and Overall Artery Biomechanics

2008 ◽  
Author(s):  
Ramji Venkatasubramanian ◽  
Wim Wolkers ◽  
Charles Soule ◽  
Paul Iaizzo ◽  
John Bischof
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Collagen Matrix ◽  
Tensile Tests ◽  
Bulk Water ◽  
Uniaxial Tensile ◽  
Matrix Structure ◽  
Cell Contractility ◽  
Freeze Thaw

Applications involving freeze-thaw in arteries such as cryoplasty and cryopreservation alter the arterial biomechanics significantly [1]. Tissue dehydration or bulk water loss is observed following freeze-thaw in native arteries as well as other artificial tissues [1, 2]. It is hypothesized that tissue dehydration observed during freeze-thaw is an important mechanism underlying the biomechanical changes in arteries. In order to test this hypothesis, dehydration was induced in arteries (without changing temperature or phase) by treating them with different concentrations of hyperosmotic mannitol solutions. Changes to smooth muscle cell (SMC) contractility, collagen matrix structure and overall artery biomechanics were studied following tissue dehydration. SMC contractility and relaxation were measured by studying the response of arteries to norepinephrine (NE) and acetylcholine (AC) respectively. Collagen matrix structure was assessed by studying the thermal denaturation of collagen due to heating using Fourier transform infrared (FTIR) spectroscopy and the overall artery biomechanics through uniaxial tensile tests.

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