36 Expression and Function of Slc26a9 Member of the SLC26 Anion Transporter Family in the Gastrointestinal Tract

2013 ◽  
Vol 144 (5) ◽  
pp. S-10 ◽  
Author(s):  
Xuemei Liu ◽  
Taolang Li ◽  
Brigitte Riederer ◽  
Anurag K. Singh ◽  
Weiliang Xia ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Anion Transporter ◽  
Transporter Family ◽  
And Function

scholarly journals Mitochondrial Uncoupling Proteins (UCPs) as Key Modulators of ROS Homeostasis: A Crosstalk between Diabesity and Male Infertility?

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1746
Author(s):  
Bruno S. Monteiro ◽  
Laís Freire-Brito ◽  
David F. Carrageta ◽  
Pedro F. Oliveira ◽  
Marco G. Alves
Keyword(s):  
Oxidative Stress ◽  
Membrane Potential ◽  
Male Infertility ◽  
Uncoupling Proteins ◽  
Metabolic Efficiency ◽  
Intermembrane Space ◽  
Ros Production ◽  
Anion Transporter ◽  
Transporter Family ◽  
And Function

Uncoupling proteins (UCPs) are transmembrane proteins members of the mitochondrial anion transporter family present in the mitochondrial inner membrane. Currently, six homologs have been identified (UCP1-6) in mammals, with ubiquitous tissue distribution and multiple physiological functions. UCPs are regulators of key events for cellular bioenergetic metabolism, such as membrane potential, metabolic efficiency, and energy dissipation also functioning as pivotal modulators of ROS production and general cellular redox state. UCPs can act as proton channels, leading to proton re-entry the mitochondrial matrix from the intermembrane space and thus collapsing the proton gradient and decreasing the membrane potential. Each homolog exhibits its specific functions, from thermogenesis to regulation of ROS production. The expression and function of UCPs are intimately linked to diabesity, with their dysregulation/dysfunction not only associated to diabesity onset, but also by exacerbating oxidative stress-related damage. Male infertility is one of the most overlooked diabesity-related comorbidities, where high oxidative stress takes a major role. In this review, we discuss in detail the expression and function of the different UCP homologs. In addition, the role of UCPs as key regulators of ROS production and redox homeostasis, as well as their influence on the pathophysiology of diabesity and potential role on diabesity-induced male infertility is debated.

scholarly journals Structure and Function of the CFTR Chloride Channel

1999 ◽  
Vol 79 (1) ◽  
pp. S23-S45 ◽  
Author(s):  
DAVID N. SHEPPARD ◽  
MICHAEL J. WELSH
Keyword(s):  
Cystic Fibrosis ◽  
Chloride Channel ◽  
Atp Hydrolysis ◽  
Current Knowledge ◽  
Structure And Function ◽  
Binding Domains ◽  
Transporter Family ◽  
Membrane Spanning ◽  
And Function ◽  
R Domain

Sheppard, David N., and Michael J. Welsh. Structure and Function of the CFTR Chloride Channel. Physiol. Rev. 79 , Suppl.: S23–S45, 1999. — The cystic fibrosis transmembrane conductance regulator (CFTR) is a unique member of the ABC transporter family that forms a novel Cl− channel. It is located predominantly in the apical membrane of epithelia where it mediates transepithelial salt and liquid movement. Dysfunction of CFTR causes the genetic disease cystic fibrosis. The CFTR is composed of five domains: two membrane-spanning domains (MSDs), two nucleotide-binding domains (NBDs), and a regulatory (R) domain. Here we review the structure and function of this unique channel, with a focus on how the various domains contribute to channel function. The MSDs form the channel pore, phosphorylation of the R domain determines channel activity, and ATP hydrolysis by the NBDs controls channel gating. Current knowledge of CFTR structure and function may help us understand better its mechanism of action, its role in electrolyte transport, its dysfunction in cystic fibrosis, and its relationship to other ABC transporters.

Radiographic Studies on the Structure and Function of the Gastrointestinal Tract of Two Species of Potoroine Marsupials.

1985 ◽  
Vol 33 (5) ◽  
pp. 641 ◽  
Author(s):  
ID Hume ◽  
CH Carlisle
Keyword(s):  
Gastrointestinal Tract ◽  
Contrast Medium ◽  
Barium Sulphate ◽  
Structure And Function ◽  
And Function ◽  
Potorous Tridactylus

The structure and function of the gastrointestinal tracts of 2 potoroine marsupials, Aepyprymnus rufescens, the rufous rat-kangaroo, and Potorous tridactylus, the long-nosed potoroo, were examined by the use of radiographic and fluoroscopic techniques. In both species barium sulphate given by mouth entered the sacciform forestomach within 20 min of dosing, but in the same time the hindstomach and duodenum were clearly outlined. Contrast medium reached the hindgut within 1 to 2 h, but was retained there for at least 24 h. A proportion of radio-opaque particles given by mouth also bypassed the sacciform forestomach, but those that entered the gastric region were retained there for up to 93 h. The stomach constituted 50% of total gut capacity, and the hindgut (caecum and colon) 35%. The sacciform forestomach was the largest gastric region. It is concluded that, on the basis of anatomy and digesta movements, the forestomach may be less important, and the hindgut more important, in fermentative digestion in the Potoroinae than in the Macropodidae.

scholarly journals SLCO4A1-AS1 Facilitates the Malignant Phenotype via miR-149-5p/STAT3 Axis in Gastric Cancer Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Qing Li ◽  
Dachuan Zhang ◽  
Hui Wang ◽  
Jun Xie ◽  
Lei Peng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Organic Anion ◽  
Organic Anion Transporter ◽  
Gastric Cancer Cells ◽  
Anion Transporter ◽  
Transporter Family ◽  
Cancer Tissues ◽  
Development Of Gastric Cancer

Solute carrier organic anion transporter family member 4A1 (SLCO4A1-AS1), a newly discovered lncRNA, may exert effects in tumors. Since its role in gastric cancer remains obscure, we sought to explore the mechanism of SLCO4A1-AS1 in gastric cancer. The relationship among SLCO4A1-AS1, miR-149-5p, and STAT3 was detected by bioinformatics, dual luciferase analysis, and Pearson’s test, and the expressions of these genes were determined by quantitative real-time PCR and Western blot. Moreover, CCK-8, flow cytometry, wound healing assay, and Transwell analysis were performed to verify the function of SLCO4A1-AS1 in gastric cancer. Rescue experiments were used to detect the role of miR-149-5p. The expressions of SLCO4A1-AS1 and STAT3 were increased, while the expression of miR-149-5p was suppressed in gastric cancer tissues and cell lines. In addition, STAT3 expression was negatively correlated with miR-149-5p expression but was positively correlated with SLCO4A1-AS1 expression. Overexpression of SLCO4A1-AS1 promoted cell viability, migration, invasion, and STAT3 expression but suppressed apoptosis, while knockdown of SLCO4A1-AS1 had the opposite effect. SLCO4A1-AS1 bound to miR-149-5p and targeted STAT3. Moreover, miR-149-5p mimic inhibited the malignant development of gastric cancer cells and obviously reversed the function of SLCO4A1-AS1 overexpression. Our research reveals that abnormally increased SLCO4A1-AS1 expression may be an important molecular mechanism in the development of gastric cancer.

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