Sa1221 Rpc1063, a Potent, Selective S1P1 Receptor Modulator, Is Active in a Therapeutic IBD Model and Exhibits Favorable PK/PD Properties in Healthy Volunteers

2013 ◽  
Vol 144 (5) ◽  
pp. S-234 ◽  
Author(s):  
Jennifer Brooks ◽  
Robert J. Peach ◽  
Marcus Boehm ◽  
Enugurthi Brahmachary ◽  
Bryan Clemons ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
S1p1 Receptor ◽  
Receptor Modulator

scholarly journals Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials

2016 ◽  
Vol 7 (3) ◽  
pp. 283-288 ◽  
Author(s):  
T. G. Murali Dhar ◽  
Hai-Yun Xiao ◽  
Jenny Xie ◽  
Lois D. Lehman-McKeeman ◽  
Dauh-Rurng Wu ◽  
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Keyword(s):  
Clinical Trials ◽  
S1p1 Receptor ◽  
Receptor Modulator ◽  
Preclinical Pharmacology

scholarly journals 6 Efficacy of cenerimod, a selective S1P1 receptor modulator, in the MRL/lpr mouse model of systemic lupus erythematosus

2019 ◽  
Author(s):  
Marianne M Martinic ◽  
Sylvie Froidevaux ◽  
Estelle Gerossier-Creusat ◽  
Enrico Vezzali ◽  
Anna Stalder ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mouse Model ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
S1p1 Receptor ◽  
Receptor Modulator

scholarly journals Pharmacokinetics, Pharmacodynamics, Tolerability, and Food Effect of Cenerimod, a Selective S1P1 Receptor Modulator in Healthy Subjects

2017 ◽  
Vol 18 (12) ◽  
pp. 2636 ◽  
Author(s):  
Pierre-Eric Juif ◽  
Daniela Baldoni ◽  
Maribel Reyes ◽  
Darren Wilbraham ◽  
Salvatore Febbraro ◽  
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Keyword(s):  
Healthy Subjects ◽  
Food Effect ◽  
S1p1 Receptor ◽  
Receptor Modulator

Modeling the Effect of the Selective S1P1 Receptor Modulator Ponesimod on Subsets of Blood Lymphocytes

2016 ◽  
Vol 34 (3) ◽  
pp. 599-609 ◽  
Author(s):  
Dominik Lott ◽  
Andreas Krause ◽  
Christian A. Seemayer ◽  
Daniel S. Strasser ◽  
Jasper Dingemanse ◽  
...  
Keyword(s):  
Blood Lymphocytes ◽  
S1p1 Receptor ◽  
Receptor Modulator

Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers

2014 ◽  
Vol 3 (3) ◽  
pp. 170-178 ◽  
Author(s):  
Jianfeng Xu ◽  
Frank Gray ◽  
Alex Henderson ◽  
Kirsty Hicks ◽  
Jiansong Yang ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Receptor Modulator ◽  
Sphingosine 1 Phosphate
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