Su1930 Differences in Molecular Alterations and Cellular Phenotype in Background Mucosa of Early Gastric Cancer With and Without H. pylori Infection

Abstract Early gastric cancer (EGC) with metachronous lesions developing on scars after endoscopic submucosal dissection (ESD) is extremely rare and hard to treat. We evaluated whether DNA methylation of the cancer-specific methylation gene, cysteine dioxygenase type 1 (CDO1), would predict such lesions. CDO1 methylation (TaqMeth) values were compared between 11 patients with metachronous lesions developing on scars after ESD (M group) identified from 2,055 patients (0.5%) and 33 patients with EGC with no confirmed evidence of metachronous lesions at > 3 years after ESD (solitary [S] group). To assess Helicobacter pylori influence, 11 H. pylori-negative EGC patients (N group) were also analyzed. Each ESD specimen was measured at the tumor (T) and 4-points separated tumor-adjacent noncancerous mucosa (TAM). TaqMeth values for T were significantly higher than TAM (S + M) (P = 0.0019) and TAM (N) (P < 0.0001). Moreover, TAM (M) had significantly higher TaqMeth values than TAM (S) (P < 0.0001) suggesting that TAM (M) exhibited CDO1 hypermethylation similar to T (P = 0.5713). Additionally, TaqMeth values for TAM (S) were significantly higher than TAM (N) (P < 0.0001). The receiver operating characteristic for discriminating the highest TaqMeth values separated TAMs (M) from those of TAMs (S) was 0.81. CDO1 hypermethylation promisingly predicted EGC with metachronous lesions developing on scars after ESD.

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The effect of Helicobacter pylori eradication on prognosis of postoperative early gastric cancer: a multicenter study

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02343-x ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Liang Wang ◽

Jinfeng Wang ◽

Sha Li ◽

Fei Bai ◽

Hailong Xie ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Overall Survival ◽

Helicobacter Pylori ◽

Early Gastric Cancer ◽

Positive Node ◽

Node Metastasis ◽

Undifferentiated Type ◽

Independent Risk Factors ◽

H Pylori

Abstract Objective To investigate the effect of Helicobacter pylori (H. pylori) eradication on the prognosis of postoperative early gastric cancer (EGC). Methods This is a retrospective study based on data from 6 hospitals. We identified 429 patients with EGC who underwent curative gastrectomy from January 2010 to December 2016. All of the patients were tested for H. pylori. Patients were divided into two groups, the successful H. pylori eradication group (group A, 268 patients) and the non-H. pylori eradication group (group B, 161 patients), for calculating the disease-free survival (DFS) and overall survival (OS) of each group. Result Positive node metastasis (hazard ratio (HR), 3.13; 95% confidence interval (CI), 1.84–5.32; P < 0.001), undifferentiated type (HR, 2.54; 95% CI, 1.51–4.28; P < 0.001), and non-H. pylori eradication (HR, 1.73; 95% CI, 1.08–2.77; P = 0.023) were statistically significantly independent risk factors of recurrence. Patient’s age ≥60 years old (HR, 3.32; 95% CI, 2.00–5.53; P < 0.001), positive node metastasis (HR, 3.71; 95% CI, 2.25–6.12; P < 0.001), undifferentiated type (HR, 3.06; 95% CI, 1.79–5.23; P < 0.001), and non-H. pylori eradication (HR, 1.83; 95% CI, 1.11–3.02; P = 0.018) were statistically significantly independent risk factors of overall survival. Conclusion H. pylori eradication treatment could prevent the recurrence of postoperative EGC to prolong the overall survival of patients with EGC.

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Abstract 542: CEACAM6 is upregulated by the H Pylori CAG-A oncoprotein, and is a candidate biomarker for the diagnosis of early gastric cancer

10.1158/1538-7445.am2015-542 ◽

2015 ◽

Cited By ~ 1

Author(s):

Anand D. Jeyasekharan ◽

Rony K. Roy ◽

Michal M. Hoppe ◽

Kar Tong Tan ◽

Henry Yang ◽

...

Keyword(s):

Gastric Cancer ◽

Early Gastric Cancer ◽

H Pylori ◽

Cag A

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Helicobacter pylori Infection following Endoscopic Resection of Early Gastric Cancer

BioMed Research International ◽

10.1155/2019/9824964 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

Lan Li ◽

Chaohui Yu

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Early Gastric Cancer ◽

Endoscopic Resection ◽

Precancerous Lesions ◽

Cost Effective ◽

Reduce Healthcare Cost ◽

Metachronous Gastric Cancer ◽

H Pylori ◽

Meta Analyses

The role of Helicobacter pylori (H. pylori) infection in patients following endoscopic resection of early gastric cancer (EGC) remains unclear. This article presents a review of literature published in the past 15 years. H. pylori‐mediated persistent methylation levels are associated with the development of metachronous gastric cancer. The methylation of certain specific genes can be used to identify patients with a high risk of metachronous gastric cancer even after H. pylori eradication. H. pylori eradication after endoscopic resection should be performed as early as possible for eradication success and prevention of metachronous precancerous lesions. Although whether the eradication of H. pylori could prevent the development of metachronous cancer after endoscopic resection is controversial, several meta‐analyses concluded that H. pylori eradication could reduce the incidence of metachronous gastric cancer significantly. In addition, H. pylori eradication in gastric cancer survivors after endoscopic resection could reduce healthcare cost and save lives in a cost‐effective way. Taken together, H. pylori eradication after endoscopic resection of EGC is recommended as prevention for metachronous precancerous lesions and metachronous gastric cancer.

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