The effect of Helicobacter pylori eradication on prognosis of postoperative early gastric cancer: a multicenter study

Abstract Objective To investigate the effect of Helicobacter pylori (H. pylori) eradication on the prognosis of postoperative early gastric cancer (EGC). Methods This is a retrospective study based on data from 6 hospitals. We identified 429 patients with EGC who underwent curative gastrectomy from January 2010 to December 2016. All of the patients were tested for H. pylori. Patients were divided into two groups, the successful H. pylori eradication group (group A, 268 patients) and the non-H. pylori eradication group (group B, 161 patients), for calculating the disease-free survival (DFS) and overall survival (OS) of each group. Result Positive node metastasis (hazard ratio (HR), 3.13; 95% confidence interval (CI), 1.84–5.32; P < 0.001), undifferentiated type (HR, 2.54; 95% CI, 1.51–4.28; P < 0.001), and non-H. pylori eradication (HR, 1.73; 95% CI, 1.08–2.77; P = 0.023) were statistically significantly independent risk factors of recurrence. Patient’s age ≥60 years old (HR, 3.32; 95% CI, 2.00–5.53; P < 0.001), positive node metastasis (HR, 3.71; 95% CI, 2.25–6.12; P < 0.001), undifferentiated type (HR, 3.06; 95% CI, 1.79–5.23; P < 0.001), and non-H. pylori eradication (HR, 1.83; 95% CI, 1.11–3.02; P = 0.018) were statistically significantly independent risk factors of overall survival. Conclusion H. pylori eradication treatment could prevent the recurrence of postoperative EGC to prolong the overall survival of patients with EGC.

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Detection of Early Gastric Cancer after Helicobacter pylori Eradication

Digestion ◽

10.1159/000519838 ◽

2021 ◽

pp. 1-8

Author(s):

Satoki Shichijo ◽

Noriya Uedo ◽

Tomoki Michida

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Helicobacter Pylori ◽

Early Gastric Cancer ◽

Eradication Therapy ◽

Low Grade ◽

Gastric Cancers ◽

Risk Patients ◽

Linked Color Imaging ◽

H Pylori

Background: Based on evidence that Helicobacter pylori eradication reduces the development of gastric cancer and other diseases such as peptic ulcer, eradication therapy has prevailed. However, gastric cancer can develop even after successful eradication. Summary: In this review article, we searched for studies that identified the characteristics of primary and metachronous gastric cancers after H. pylori eradication, the risk factors for the development of these cancers after successful H. pylori eradication, and whether image-enhanced endoscopy is useful for diagnosing gastric cancer after eradication. A gastritis-like appearance is seen as a characteristic endoscopic finding, which corresponds to an epithelium with low-grade atypia – also known as nonneoplastic epithelium – covering the surface of the cancerous glands. This finding may make endoscopic detection of early gastric cancer difficult after H. pylori eradication. Similar risk factors, such as the male sex, endoscopic atrophy, histologic intestinal metaplasia, and late eradication, have been reported as predictors for the development of both primary and metachronous gastric cancers. Image-enhanced endoscopy, such as linked color imaging, may be useful for the detection and risk stratification of gastric cancer after eradication. Key Messages: Based on these findings, we believe that effective surveillance of high-risk patients leads to early detection of gastric cancer in the era of H. pylori eradication.

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The Effect of Helicobacter Pylori Eradication On Prognosis Of Postoperative Early Gastric Cancer: A Multicenter Study

10.21203/rs.3.rs-208181/v1 ◽

2021 ◽

Author(s):

Liang Wang ◽

Jinfeng Wang ◽

Sha Li ◽

Fei Bai ◽

Hailong Xie ◽

...

Keyword(s):

Gastric Cancer ◽

Overall Survival ◽

Helicobacter Pylori ◽

Early Gastric Cancer ◽

Disease Free Survival ◽

Curative Gastrectomy ◽

Free Survival ◽

H Pylori ◽

Group B ◽

Disease Free

Abstract Objective: To investigate the effect of Helicobacter pylori (H. pylori) eradication on the prognosis of postoperative early gastric cancer (EGC).Methods: This is a retrospective study based on data from 6 hospitals. We identified patients with EGC who underwent curative gastrectomy from January 2010 to December 2016. All of the patients were tested for H. pylori. Patients were divided into two groups, the successful H. pylori eradication group (Group A) and the non-H. pylori eradication group (Group B), for calculating the disease-free survival (DFS) and overall survival (OS) of each group.Result: Non-H. pylori eradication were statistically significant independent risk factors of overall survival (hazard ratio (HR), 1.760; 95% confidence interval (CI), 1.067-2.902; P=0.027) and disease-free survival (HR, 1.728; 95% CI, 1.077-2.772; P=0.023).Conclusion: Eradication treatment for H. pylori can prevent the recurrence of postoperative early gastric cancer.

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Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer

Gastric Cancer ◽

10.1007/s10120-020-01103-2 ◽

2020 ◽

Vol 24 (1) ◽

pp. 168-178 ◽

Cited By ~ 1

Author(s):

Hyo-Joon Yang ◽

Jae-Young Jang ◽

Sang Gyun Kim ◽

Ji Yong Ahn ◽

Su Youn Nam ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Early Gastric Cancer ◽

Endoscopic Resection ◽

Node Metastasis ◽

Undifferentiated Type

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The Characteristics, Prognosis, and Risk Factors of Lymph Node Metastasis in Early Gastric Cancer

Gastroenterology Research and Practice ◽

10.1155/2018/6945743 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 7

Author(s):

Xuan Li ◽

Shiyu Liu ◽

Jin Yan ◽

Lei Peng ◽

Meihong Chen ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Multivariate Analysis ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Early Gastric Cancer ◽

Depth Of Invasion ◽

Node Metastasis ◽

Independent Risk Factors ◽

Male Sex

Background. Lymph node metastasis (LNM) is the most important risk factor for endoscopic treatment in early gastric cancer (EGC) patients. We aimed to investigate the rate of LNM, the risk factors, and the prognosis of EGC patients with LMN. Methods. A total of 10,039 patients who underwent gastrectomy with lymphadenectomy were reviewed between January 2010 and December 2015 at Jiangsu Province Hospital in China. Among them, we identified 1004 (10%) EGCs. First, endoscopic and clinicopathological features related to LNM were analyzed, and then risk factors for LNM were identified using univariate and multivariate analysis. Finally, the short- and long-term outcomes were compared between the groups. Results. LNM occurred in 123 (12.3%) EGCs. Most of EGCs were male (n=720, 71.7%) and mean age was 59.65 ± 11.09 years. The rate of H. pylori infection was 78.0% (783/1004). LNM was significantly associated with age, sex, location, lesion size, macroscopic type, depth of invasion, differentiation type, histological morphology, lymphovascular invasion (LVI), and TMN stage. By multivariate analysis, significant independent risk factors for LNM in EGC were identified as following: male sex (OR 2.365, P=0.035), age ≦ 40 (OR 0.055, P=0.012), depressed type (OR 2.721, P=0.013), submucosa invasion (OR 2.987, P=0.032), LVI (OR 5.186, P=0.003), tumor located in corpora (OR 8.904, P=0.047), and in angle (OR 12.998, P=0.024). 86.5% were successfully followed up for 3 years. The overall 1- and 3-year survival rates in LNM group were 100% and 91.1%, respectively, and those with no LNM were 100% and 100%, respectively. Conclusion. EGCs were investigated in 10.0% of gastric cancer, which LNM occurred in 12.3% of EGC. Independent risk factors of LNM included male sex, age (>40), the depth of invasion, LVI, and tumor located in corpora or angle. The 3-year overall survival rate was greater in EGC patients without LNM.

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Risk factors of tumor invasion and node metastasis in early gastric cancer with undifferentiated component: a multicenter retrospective study on biopsy specimens and clinical data

Annals of Translational Medicine ◽

10.21037/atm.2020.02.42 ◽

2020 ◽

Vol 8 (6) ◽

pp. 360-360

Author(s):

Yi Zou ◽

Long Wu ◽

Yubin Yang ◽

Xin Shen ◽

Chunpeng Zhu

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Retrospective Study ◽

Early Gastric Cancer ◽

Clinical Data ◽

Tumor Invasion ◽

Node Metastasis ◽

Biopsy Specimens

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Exploration of endoscopic findings and risk factors of early gastric cancer after eradication of Helicobacter pylori

Scandinavian Journal of Gastroenterology ◽

10.1080/00365521.2020.1868567 ◽

2021 ◽

pp. 1-7

Author(s):

Xiaohan Yan ◽

Xiao Hu ◽

Bensong Duan ◽

Xuesong Zhang ◽

Jie Pan ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Helicobacter Pylori ◽

Early Gastric Cancer ◽

Endoscopic Findings

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Risk Factors for Lymph Node Metastasis in Early Gastric Cancer with Signet Ring Cell Carcinoma

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-015-2915-z ◽

2015 ◽

Vol 19 (11) ◽

pp. 1958-1965 ◽

Cited By ~ 15

Author(s):

Chun Guang Guo ◽

Dong Bing Zhao ◽

Qian Liu ◽

Zhi Xiang Zhou ◽

Ping Zhao ◽

...

Keyword(s):

Risk Factors ◽

Gastric Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Early Gastric Cancer ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Node Metastasis ◽

Signet Ring ◽

Ring Cell

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Helicobacter pylori Recurrence after Eradication Therapy in Jiangjin District, Chongqing, China

Gastroenterology Research and Practice ◽

10.1155/2020/7510872 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Gang Zhou

Keyword(s):

Risk Factors ◽

Helicobacter Pylori ◽

Recurrence Rate ◽

Standard Therapy ◽

Family Members ◽

Significant Difference ◽

Independent Risk Factors ◽

Eating Out ◽

H Pylori ◽

Infection Recurrence

Purpose. To investigate the recurrence rate of Helicobacter pylori infection after eradication in Jiangjin District, Chongqing, China, and to analyze the related causes. Methods. Outpatients who were eradicated of H. pylori infection with standard therapy between August 2014 and August 2017 were included in this study. The recurrence rate was investigated 1 year later. Data regarding gender, smoking, alcohol intake, frequency of eating out, and treatment strategy were recorded, and their relationships with the recurrence rate were analyzed. Multivariate logistic regression analysis was performed to determine the independent risk factors for H. pylori infection recurrence. Results. In total, 400 patients (225 males and 175 females) were included in this study. Of them, the recurrence rate of H. pylori infection was 4.75% (19/400), with 5.33% (12/225) in males and 4.57% (7/175) in females, showing no gender difference. The recurrence rate was 7.03% (9/128) in smokers and 3.68% (10/272) in nonsmokers, while it was 6.45% (12/186) in those who drink alcohol and 3.27% (7/214) in those who do not drink alcohol, showing no significant differences. The higher the frequency of eating out, the higher the recurrence rate of H. pylori infection (P=0.001). There was a statistically significant difference in the recurrence rate between patients receiving treatment alone and patients whose family members also received treatment (6.08% vs. 0.96%, P=0.035). Drinking and dining out were independent risk factors for H. pylori infection recurrence (P=0.014 for drinkers and P=0.015 and P=0.003 for those who sometimes and often dine out, respectively). Conclusions. The overall recurrence rate after H. pylori eradication by standard therapy in Jiangjin District is 4.75%. Reducing the frequency of eating out and family members receiving treatment may reduce the recurrence of H. pylori infection.

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