Tu1946 Correlation of Endobiliary Brush Cytology to Fine Needle Aspiration in Suspected Pancreaticobiliary Malignancies Using a New Large Caliber Endobiliary Brush

Background: Lung cancer is the most common cancer incidence wise as well as leading cause of cancer related death in worldwide as well as in India. Cytological diagnosis plays an important role in patients having lung cancer. This study was conducted to evaluate sensitivity of various cytological methods in diagnosis of lung cancer, to study typing of lung cancer, age and gender wise distribution of lung cancer and its association with smoking.Methods: This study includes patients having clinical and radiological diagnosis of lung cancer. Total 150 cases of entire January 2015 to December 2015 are included. Methods obtaining samples includes, abrasive cytology by bronchoscope guided: bronchoalveolar lavage (BAL); brush cytology and bronchial washing, CT/USG guided transthoracic fine needle aspiration, trans- bronchial needle aspiration. Samples have been processed as per standard protocols and cytomorphology of samples are studied, along with these patient age, gender, and smoking habit have been recorded.Results: Sensitivity of various method: abrasive cytology by bronchoscope guided bronchoalveolar lavage (BAL); brush cytology and bronchial washing, trance bronchial needle aspiration, CT/USG guided transthoracic fine needle aspiration is 70%, 66%, 90% respectively. Adenocarcinoma is most common carcinoma followed by squamous carcinoma, having incident of 41%, 31.39% respectively. In male patient peak age is 5th decade, and in female peak age is 6th decade. Male:female ratio is 5.1:1. Adenocarcinoma is most common carcinoma is 10 times more common in non-smokers as compare to squamous cell carcinoma .But association of squamous cell carcinoma with smoking is 97%.Conclusions: CT/USG guided transthoracic fine needle aspiration method has highest sensitivity. In male patients peak age of presentation of lung carcinoma is 5th decade, and in female patient’s peak age is 6th decade. Lung carcinoma found to be more common in males than in females. Adenocarcinoma is most common carcinoma. It is 10 times more common in non-smokers as compare to squamous cell carcinoma. Association of squamous cell carcinoma with smoking is 97%.

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ENDOSCOPIC ULTRASONOGRAPHY GUIDED FINE-NEEDLE ASPIRATION FOR DISTAL COMMON BILE DUCT TUMORS AND STRICTURES: MORE EFFECTIVE THAN ERCP AND BRUSH CYTOLOGY

10.1055/s-0040-1704477 ◽

2020 ◽

Author(s):

P Desai ◽

M Kabrawala ◽

C Patel ◽

P Kalra ◽

N Patel ◽

...

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Endoscopic Ultrasonography ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Brush Cytology ◽

Distal Common Bile Duct ◽

Fine Needle ◽

Bile Duct Tumors

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EUS-Guided Fine-Needle Aspiration of Suspected Hilar Cholangiocarcinoma in Potentially Operable Patients with Negative Brush Cytology

The American Journal of Gastroenterology ◽

10.1046/j.1572-0241.2003.04006.x ◽

2004 ◽

Vol 99 (1) ◽

pp. 45-51 ◽

Cited By ~ 174

Author(s):

A Fritscher-Ravens ◽

D C Broering ◽

W T Knoefel ◽

X Rogiers ◽

P Swain ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Hilar Cholangiocarcinoma ◽

Needle Aspiration ◽

Brush Cytology ◽

Fine Needle

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Efficacy and safety of EUS guided fine needle aspiration in patients with suspected malignant hilar tumors and negative brush cytology

Gastroenterology ◽

10.1016/s0016-5085(03)80488-2 ◽

2003 ◽

Vol 124 (4) ◽

pp. A99

Author(s):

Annette Fritscher-Ravens ◽

Dieter Broering ◽

C. Paul Swain ◽

Xavier Rogiers ◽

Theodoros Topalidis ◽

...

Keyword(s):

Fine Needle Aspiration ◽

Needle Aspiration ◽

Efficacy And Safety ◽

Brush Cytology ◽

Fine Needle

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Agreement between endoscopic ultrasound-guided fine-needle aspiration and endobiliary brush cytology in suspected pancreaticobiliary malignancies

Endoscopy International Open ◽

10.1055/s-0043-119754 ◽

2017 ◽

Vol 05 (12) ◽

pp. E1251-E1258

Author(s):

Matthew Sullivan ◽

Hope Kincaid ◽

Shashin Shah ◽

Hiral Shah

Keyword(s):

Endoscopic Ultrasound ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Brush Cytology ◽

Ultrasound Guided ◽

Cohen’S Kappa ◽

Detection Rates ◽

Fine Needle ◽

Cohen's Kappa ◽

Moderate Agreement

Abstract Background and study aims For suspected pancreaticobiliary malignancies, endobiliary brush cytology during endoscopic retrograde cholangiopancreatography (ERCP) remains the diagnostic test of choice despite historically poor and variable sensitivity. This has led to increased use of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) as an initial test. Recently, our institution began using a cytology brush that was designed specifically to collect a more substantial and higher-quality sample. The aim of this study was to investigate whether this brush design would provide more adequate samples and have high agreement with EUS-FNA in patients who underwent both procedures. Patients and methods A retrospective chart review was conducted of all patients who underwent both EUS-FNA and endobiliary brush cytology for suspicion of pancreaticobiliary malignancy from January 2013 to May 2015. A total of 41 patients met the inclusion criteria. Initially, sample quality was evaluated. Final cytology results were then assessed for agreement with EUS-FNA using Cohen’s kappa. The effect of considering atypical cytology as negative was also uniquely evaluated by running separate analyses. Results Brush cytology provided an adequate sample in 95.1 % of cases. Cohen’s Kappa demonstrated moderate agreement between brush cytology and EUS-FNA: κ = 0.42 (P = 0.001). When atypical results were excluded, agreement increased: κ = 0.60 (P = 0.02), but remained moderate. If atypical results were considered “positive,” the two procedures demonstrated equal cancer detection rates of 80.8 %. Conclusions The studied brush provided more adequate samples compared with historical rates for brush cytology and had moderate agreement with EUS-FNA. If this brush truly increases sample adequacy, it could potentially provide results comparable to EUS-FNA at lower cost.

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