Mo1923 Polymorphisms in the Mannose Binding Lectin Gene Are Associated With the Defect of the Mannose Binding Lectin Functional Activity in Crohn's Disease Patients

2016 ◽  
Vol 150 (4) ◽  
pp. S817
Author(s):  
Laura Choteau ◽  
Francis Vasseur ◽  
Frederic Lepretre ◽  
Martin Figeac ◽  
Laurent Dubuquoy ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Functional Activity ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Laura Choteau ◽  
Francis Vasseur ◽  
Frederic Lepretre ◽  
Martin Figeac ◽  
Corine Gower-Rousseau ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Functional Activity ◽  
Serine Proteases ◽  
Mannose Binding Lectin ◽  
Lectin Pathway ◽  
Disease Phenotype ◽  
Mannose Binding ◽  
Antibody Levels ◽  
Binding Lectin

Abstract Mannose-binding lectin, together with mannose-associated serine proteases, activates the lectin pathway of the complement system and subsequent inflammatory mechanisms. An association between mannose-binding lectin deficiency and anti-Saccharomyces cerevisiae antibody levels is observed in Crohn’s disease and this deficiency is frequently associated with a severe Crohn’s disease phenotype. In the present study, we assessed the relationship between serum concentrations of mannose-binding lectin, mannose-binding lectin functional activity, MBL2 and NOD2 polymorphisms, anti-S. cerevisiae antibody levels and clinical Crohn’s disease phenotype in 69 Crohn’s disease patients and 30 age- and sex-matched healthy controls. The results show that the MBL2 variant rs5030737 at codon 52 was associated with a low level of mannose-binding lectin and impaired mannose-binding lectin–mannose-associated serine protease (MBL-MASP) functional activity in Crohn’s disease patients. This MBL2 variant was also associated with a higher level of anti-S. cerevisiae antibodies. In addition, the NOD2 variant rs2066844, which is associated with susceptibility to Crohn’s disease, was significantly correlated with an impairment in MBL-MASP functional activity. These results provide evidence that Crohn’s disease patients have an impairment in MBL-MASP functional activity and that this defect is associated with MBL2 and NOD2 variants.

Mannose-binding lectin deficiency is not associated with Anti-Saccharomyces cerevisiae antibody in Korean Crohn's disease patients

2014 ◽  
Vol 429 ◽  
pp. 206-211 ◽  
Author(s):  
You Sun Kim ◽  
Young-Ho Kim ◽  
Byong Duk Ye ◽  
Dong Won Park ◽  
Ji Won Kim ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

Mannan-binding lectin gene polymorphisms in ulcerative colitis and Crohn's disease

2001 ◽  
Vol 120 (5) ◽  
pp. A459-A459
Author(s):  
A RECTOR ◽  
P LEMEY ◽  
W LAFFUT ◽  
E KEYAERTS ◽  
F STRUYF ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gene Polymorphisms ◽  
Lectin Gene ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Molecular cloning and characterization of a mannose-binding lectin gene from Crinum asiaticum

2003 ◽  
Vol 160 (8) ◽  
pp. 913-920 ◽  
Author(s):  
Yourong Chai ◽  
Yongzhen Pang ◽  
Zhihua Liao ◽  
L.e.i. Zhang ◽  
Xiaofen Sun ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Crinum Asiaticum ◽  
Binding Lectin

scholarly journals Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

2021 ◽  
Vol 54 ◽  
Author(s):  
Saulo Gomes de Oliveira ◽  
Ilana Brito Ferraz de Souza ◽  
Taynan da Silva Constantino ◽  
Paula Carolina Valença Silva ◽  
Elker Lene Santos de Lima ◽  
...  
Keyword(s):  
Specific Treatment ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Periportal Fibrosis ◽  
Mannose Binding ◽  
Exon 1 ◽  
Fibrosis Regression ◽  
Binding Lectin
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