Su1237 ALTERED STRUCTURE AND FUNCTION OF MITOCHONDRIA IN AGING GASTRIC ENDOTHELIAL CELLS - KEY TO IMPAIRED ANGIOGENESIS IN AGING UNCOVERED BY ARTIFICIAL INTELLIGENCE ANALYSIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-553-S-554
Author(s):  
Amrita Ahluwalia ◽  
Neil Hoa ◽  
Ankita Ahluwalia ◽  
Andrzej S. Tarnawski
Keyword(s):  
Artificial Intelligence ◽  
Endothelial Cells ◽  
Structure And Function ◽  
Intelligence Analysis ◽  
And Function ◽  
Impaired Angiogenesis

scholarly journals Human thrombocytopenia is associated with structural abnormalities of the endothelium that are ameliorated by glucocorticosteroid administration

Blood ◽  
1986 ◽  
Vol 67 (1) ◽  
pp. 203-206 ◽  
Author(s):  
CS Kitchens ◽  
JF Pendergast
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Normal Structure ◽  
Structure And Function ◽  
Capillary Endothelium ◽  
Severe Thrombocytopenia ◽  
Structural Abnormalities ◽  
And Function

Abstract Capillary fragility is characteristic of severe thrombocytopenia. This mechanical weakness may not be solely accounted for by decreased ability of platelets to repair endothelial breaks. Platelets may have a role in maintaining endothelial hemostasis. This laboratory has demonstrated thinning of capillary endothelium in experimental thrombocytopenia. We now report similar findings in human thrombocytopenia. Capillary endothelium supplying either skin or skeletal muscle was found to have a mean thickness only half that of normal as well as frequent very thinned areas, including some fenestrations. All findings reverted toward normal after four days of prednisone administration at a time the degree of thrombocytopenia was equally severe. These findings are consistent with the hypothesis that platelets are necessary for normal structure and function of endothelial cells and that glucocorticosteroid administration may ameliorate the pathophysiology of thrombocytopenia.

scholarly journals The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells

2008 ◽  
Vol 7 (1) ◽  
Author(s):  
Inigo Martinez ◽  
Geir I Nedredal ◽  
Cristina I Øie ◽  
Alessandra Warren ◽  
Oddmund Johansen ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Oxygen Tension ◽  
Structure And Function ◽  
Liver Sinusoidal Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
And Function ◽  
Isolated Liver

Structure and function of the liver, biliary tract, and pancreas

2010 ◽  
pp. 2435-2443
Author(s):  
Alexander Gimson ◽  
Simon M. Rushbrook
Keyword(s):  
Endothelial Cells ◽  
Single Cell ◽  
Biliary Tract ◽  
Structural Unit ◽  
Structure And Function ◽  
Hepatic Veins ◽  
Canalicular Membrane ◽  
The Right ◽  
And Function ◽  
Portal Tracts

The liver, sited in the right upper quadrant of the abdomen, comprises eight segments, each of which is a complete functional unit with a single portal pedicle and a hepatic vein. Within the functional segments, the structural unit is the hepatic lobule, a polyhedron surrounded by four to six portal tracts containing hepatic arterial and portal venous branches from which blood perfuses through sinusoids, surrounded by walls of hepatocytes that are a single cell thick and lined by specialized endothelial cells with ‘windows’ (fenestrae), to the centrilobular region and the central hepatic veins. Bile secreted through the canalicular membrane of the hepatocyte collects in biliary canaliculi, from which it passes through the biliary tract into the gut....

Flavivirus and its Threat

2021 ◽  
Author(s):  
Satashree Paul
Keyword(s):  
Endothelial Cells ◽  
Nervous System ◽  
Cell Migration ◽  
Blood Brain Barrier ◽  
Immune Cell ◽  
Structure And Function ◽  
Brain Barrier ◽  
Target Cells ◽  
Immune Cell Migration ◽  
And Function

A number of studies found that the virus can activate the endothelial cells and affect the structure and function of the blood?brain barrier, promoting immune cell migration to benefit the virus nervous system target cells infected by flaviviruses.

scholarly journals Human thrombocytopenia is associated with structural abnormalities of the endothelium that are ameliorated by glucocorticosteroid administration

Blood ◽  
1986 ◽  
Vol 67 (1) ◽  
pp. 203-206 ◽  
Author(s):  
CS Kitchens ◽  
JF Pendergast
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Normal Structure ◽  
Structure And Function ◽  
Capillary Endothelium ◽  
Severe Thrombocytopenia ◽  
Structural Abnormalities ◽  
And Function

Capillary fragility is characteristic of severe thrombocytopenia. This mechanical weakness may not be solely accounted for by decreased ability of platelets to repair endothelial breaks. Platelets may have a role in maintaining endothelial hemostasis. This laboratory has demonstrated thinning of capillary endothelium in experimental thrombocytopenia. We now report similar findings in human thrombocytopenia. Capillary endothelium supplying either skin or skeletal muscle was found to have a mean thickness only half that of normal as well as frequent very thinned areas, including some fenestrations. All findings reverted toward normal after four days of prednisone administration at a time the degree of thrombocytopenia was equally severe. These findings are consistent with the hypothesis that platelets are necessary for normal structure and function of endothelial cells and that glucocorticosteroid administration may ameliorate the pathophysiology of thrombocytopenia.

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