Structure in Relation to Cellular Function

1950 ◽  
Vol 15 (3) ◽  
pp. 563
Keyword(s):  
Cellular Function

scholarly journals A modular tool to query and inducibly disrupt biomolecular condensates

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Carmen N. Hernández-Candia ◽  
Sarah Pearce ◽  
Chandra L. Tucker
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cellular Function ◽  
Biological Role ◽  
Cellular Biology ◽  
Condensate Formation ◽  
Health And Disease ◽  
Lateral Sclerosis

AbstractDynamic membraneless compartments formed by protein condensates have multifunctional roles in cellular biology. Tools that inducibly trigger condensate formation have been useful for exploring their cellular function, however, there are few tools that provide inducible control over condensate disruption. To address this need we developed DisCo (Disassembly of Condensates), which relies on the use of chemical dimerizers to inducibly recruit a ligand to the condensate-forming protein, triggering condensate dissociation. We demonstrate use of DisCo to disrupt condensates of FUS, associated with amyotrophic lateral sclerosis, and to prevent formation of polyglutamine-containing huntingtin condensates, associated with Huntington’s disease. In addition, we combined DisCo with a tool to induce condensates with light, CRY2olig, achieving bidirectional control of condensate formation and disassembly using orthogonal inputs of light and rapamycin. Our results demonstrate a method to manipulate condensate states that will have broad utility, enabling better understanding of the biological role of condensates in health and disease.

scholarly journals Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

RSC Advances ◽  
2020 ◽  
Vol 10 (71) ◽  
pp. 43383-43388
Author(s):  
Sangpil Kim ◽  
Juhee Kim ◽  
Batakrishna Jana ◽  
Ja-Hyoung Ryu
Keyword(s):  
Cancer Therapy ◽  
Cancer Cell ◽  
Chemical Reactions ◽  
Cell Imaging ◽  
Cellular Function ◽  
Aggregation Induced Emission ◽  
Cancer Cell Imaging ◽  
Anti Cancer

Controlled intracellular chemical reactions to regulate cellular function remain a challenge in biology mimetic systems.

scholarly journals Understanding MCL1: From Cellular Function and Regulation to Pharmacological Inhibition

FEBS Journal ◽  
2021 ◽  
Author(s):  
Mónica Sancho ◽  
Diego Leiva ◽  
Estefanía Lucendo ◽  
Mar Orzáez
Keyword(s):  
Cellular Function ◽  
Pharmacological Inhibition

Modulation of cellular function by polyamines

2010 ◽  
Vol 42 (1) ◽  
pp. 39-51 ◽  
Author(s):  
Kazuei Igarashi ◽  
Keiko Kashiwagi
Keyword(s):  
Cellular Function

scholarly journals Cells in tight spaces: the role of cell shape in cell function

2010 ◽  
Vol 191 (2) ◽  
pp. 233-236 ◽  
Author(s):  
Jagesh V. Shah
Keyword(s):  
Primary Cilium ◽  
Cell Shape ◽  
Cell Function ◽  
Cellular Function ◽  
Cell Geometry ◽  
Intracellular Organization ◽  
Cell Biol

In this issue, Pitaval et al. (2010. J. Cell Biol. doi:10.1083/jcb.201004003) demonstrate that cell geometry can regulate the elaboration of a primary cilium. Their findings and approaches are part of a historical line of inquiry investigating the role of cell shape in intracellular organization and cellular function.

Growth and paracrine factors regulating follicular formation and cellular function

2000 ◽  
Vol 163 (1-2) ◽  
pp. 11-20 ◽  
Author(s):  
K.P McNatty ◽  
A.E Fidler ◽  
J.L Juengel ◽  
L.D Quirke ◽  
P.R Smith ◽  
...  
Keyword(s):  
Cellular Function ◽  
Paracrine Factors
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