Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis, or adenomatous polyps after 5-aminolevulinic acid–induced protoporphyrin IX sensitization

1999 ◽  
Vol 49 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Helmut Messmann ◽  
Ruth Knüchel ◽  
Wolfgang Bäumler ◽  
Axel Holstege ◽  
Jürgen Schölmerich
Keyword(s):  
Ulcerative Colitis ◽  
Barrett’S Esophagus ◽  
Fluorescence Detection ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Adenomatous Polyps

Protoporphyrin IX Fluorescence Photobleaching and the Response of Rat Barrett's Esophagus Following 5-aminolevulinic Acid Photodynamic Therapy

2006 ◽  
Vol 82 (6) ◽  
pp. 1638 ◽  
Author(s):  
Ingrid A. Boere ◽  
Dominic J. Robinson ◽  
Henriette S. de Bruijn ◽  
Jolanda Kluin ◽  
Hugo W. Tilanus ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix

Protoporphyrin IX Fluorescence Photobleaching and the Response of Rat Barrett's Esophagus Following 5-aminolevulinic Acid Photodynamic Therapy

2006 ◽  
Vol 82 (6) ◽  
pp. 1638-1644 ◽  
Author(s):  
Ingrld A. Boere ◽  
Dominic J. Robinson ◽  
Henrietta S. Bruijn ◽  
Jolanda Kluln ◽  
Hugo W. Tllanus ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix

Detection of high-grade dysplasia in Barrett's esophagus by 5-aminolevulinic acid (ALA) induced protoporphyrin ix (PpIX) fluorescence spectroscopy

2000 ◽  
Vol 118 (4) ◽  
pp. A193 ◽  
Author(s):  
Stephan A. Brand ◽  
Thomas D. Wang ◽  
Kevin T. Schomacker ◽  
John M. Poneros ◽  
Carolyn C. Compton ◽  
...  
Keyword(s):  
Fluorescence Spectroscopy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
High Grade Dysplasia ◽  
High Grade

scholarly journals Aneuploidy Mechanisms in Human Colorectal Preneoplastic Lesions and Barrett’s Esophagus. Is There a Role for K-Ras and p53 Mutations?

1997 ◽  
Vol 15 (2) ◽  
pp. 99-117 ◽  
Author(s):  
Walter Giaretti
Keyword(s):  
Cell Cycle ◽  
Ulcerative Colitis ◽  
Barrett’S Esophagus ◽  
Chronic Ulcerative Colitis ◽  
Barrett's Esophagus ◽  
Tumour Suppressor Gene ◽  
Colorectal Adenomas ◽  
Specific Gene ◽  
Preneoplastic Lesions

The link of aneuploidy and heteroploidy in human solid tumours with early genetic events is poorly understood. The study of human preneoplastic precursor lesions, i.e., colorectal adenomas, chronic ulcerative colitis lesions, and Barrett’s esophagus, as considered in this review, appears particularly useful to achieve this aim. Literature data examined here on aneuploidy were obtained by image and flow cytometry, classical cytogenetics, andin situhybridization based cytogenetics. It appears that aneuploidy is linked with specific gene mutations, i.e., of the tumour suppressor gene p53 in chronic ulcerative colitis and in Barrett’s esophagus, and of the protooncogene K‐ras in colorectal adenomas. These data and data from experiments usingin vitroand mouse models, suggest that chromosome instability, tetraploidization, and asymmetrical chromosome segregation during cell division are the result of deregulated cell cycle genes with multiple functions that normally exert active checks on the cell cycle processes including apoptosis and chromosome stability.

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