scholarly journals A new microassay method for L-glutamic acid decarboxylase (GAD) activity

1974 ◽  
Vol 24 ◽  
pp. 79
Author(s):  
Hiroshi Kimura ◽  
Klnya Kuriyama
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Acid Decarboxylase ◽  
Gad Activity

Glutamate Dehydrogenase, Glutamic Acid Decarboxylase, and GABA Amino Transferase in Epileptic Mouse Cortex

1974 ◽  
Vol 52 (5) ◽  
pp. 952-959 ◽  
Author(s):  
N. M. van Gelder
Keyword(s):  
Glutamic Acid ◽  
Glutamate Dehydrogenase ◽  
Glutamic Acid Decarboxylase ◽  
The Other ◽  
Entire Period ◽  
Acid Decarboxylase ◽  
Gaba Aminotransferase ◽  
Mouse Cortex ◽  
Normal Enzyme ◽  
Gad Activity

Determinations of glutamate dehydrogenase (GDH), glutamic acid decarboxylase (GAD), and GABA aminotransferase (GABA-T) in the epileptogenic (cobalt) mouse cortex revealed a fall in the activities of GDH and GABA-T and an increase in GAD. However, of the three enzymes, only changes in GDH appeared to coincide with the entire period that animals were epileptic. The decrease in GABA-T was observed in the first week following the onset of cobalt-induced epilepsy but the activity of this enzyme had returned to normal before all epileptic signs had disappeared. On the other hand, the rise in GAD activity was observed 3–4 days after epilepsy had become established. Injections of taurine to animals did not influence the above findings but might have slowed recovery to normal enzyme values.

Normal glutamic decarboxylase activity in rat striatum and retina following administration of L-DOPA

1976 ◽  
Vol 54 (2) ◽  
pp. 79-82 ◽  
Author(s):  
G. Tunnicliff ◽  
R. F. Butterworth ◽  
Y. Tsukada ◽  
A. Barbeau
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Rat Striatum ◽  
Acid Decarboxylase ◽  
Decarboxylase Activity ◽  
Gad Activity

Recent reports of the in vivo action of L-dihydroxyphenylalanine (L-DOPA) on glutamic acid decarboxylase (GAD) activity are contradictory. This investigation was undertaken to clarify the situation. Both acute (100 mg/kg and 1 g/kg) and chronic (1 g/kg) administration of L-DOPA to rats failed to produce any alteration in the activity of striatal or retinal GAD activity. These results are discussed in the light of a report relating L-DOPA therapy to modification of GAD activity in Parkinson's disease.

scholarly journals The influence of NMDA and GABAA receptors and glutamic acid decarboxylase (GAD) activity on attention

2012 ◽  
Vol 225 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Alan L. Pehrson ◽  
Corina O. Bondi ◽  
Nelson K. B. Totah ◽  
Bita Moghaddam
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Gabaa Receptors ◽  
Acid Decarboxylase ◽  
Gad Activity
Sign in / Sign up

Export Citation Format

Share Document