scholarly journals Recent trend in the treatment of hypertension and antihypertensive drugs.

1996 ◽  
Vol 71 ◽  
pp. 23
Author(s):  
Takao Saruta
Keyword(s):  
Recent Trend ◽  
Antihypertensive Drugs ◽  
Treatment Of Hypertension

Diuretics in hypertension

1975 ◽  
Vol 13 (26) ◽  
pp. 101-103
Keyword(s):  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Thiazide Diuretic ◽  
Mild Hypertension ◽  
Antihypertensive Drugs ◽  
Antihypertensive Agents ◽  
Plasma Renin ◽  
Renin Activity ◽  
Thiazide Diuretics ◽  
Treatment Of Hypertension

Thiazide diuretics such as bendrofluazide and chlorothiazide have been used for nearly 20 years in the treatment of hypertension. They have been regarded as rather weak antihypertensive agents which could be used alone only in mild hypertension and otherwise as adjuvants to more potent drugs in more serious cases.1 There are however some patients with ‘essential’ hypertension who are very sensitive to diuretics and in whom the pressure may be brought down to normal by a thiazide2 or spironolactone3 even when it is initially considerably raised. Furthermore a few patients who are responsive to thiazides are strikingly unresponsive to non-diuretic antihypertensive drugs. Patients particularly likely to respond to a thiazide diuretic4 or spironolactone3 commonly have low plasma renin activity and this occurs in about 25% of patients with essential hypertension.5 Since plasma renin activity is not routinely estimated it is simplest to identify these patients by observing the response to an adequate trial of a thiazide.

Gender disparities in the prevalence, awareness, treatment, and control of high blood pressure

2021 ◽  
Vol 27 ◽  
Author(s):  
Maria Dorobantu ◽  
Oana-Florentina Gheorghe-Fronea ◽  
Alexandru Scafa-Udriste ◽  
Sebastian Onciul ◽  
Calin Pop ◽  
...  
Keyword(s):  
Older Women ◽  
Antihypertensive Drugs ◽  
Gender Disparities ◽  
Gender Effects ◽  
Evolutionary Trend ◽  
Treatment Of Hypertension ◽  
Younger Men ◽  
And Control ◽  
Gender Discrepancies ◽  
Time Awareness

: The gender effects in arterial hypertension (HT) epidemiology remains poorly clarified to date. We present an up-to-date review of the data regarding gender disparities in HT’s prevalence, awareness, treatment, and control. Based on the data from three consecutive national-representative SEPHAR (Study for the Evaluation of Prevalence of Hypertension and Cardiovascular Risk in Romania) surveys conducted between 2005 and 2016, we provide insights into gender differences in HT’s epidemiology and their 11- years evolutionary trend in a high-CV risk European country. Our data displays gender effects in different age-dependent epidemiological patterns in terms of hypertension prevalence, awareness, treatment, and control, mainly due to hormonal status. Hypertension’s prevalence is higher in younger men and older women. Although women are more often aware of their hypertensive condition and receive more often antihypertensive treatment, BP control is lower in older women compared to men of the same age, mainly due to a higher treatment side-effect rate. There is no solid evidence that different antihypertensive drugs exhibit different effects in lowering BP values between genders. In high CV risk European countries like Romania, if all the influencing conditions remain similar to those in the past 11 years, gender discrepancies in terms of HT's prevalence will diminish over time, awareness and treatment of hypertension will continue to be higher in females than in men, with an upward trend of BP control predicted only for women, while in men HT treatment control rate is expected to stagnate.

scholarly journals May Measurement Month 2018: an analysis of blood pressure screening campaign results from Poland

2020 ◽  
Vol 22 (Supplement_H) ◽  
pp. H108-H111
Author(s):  
Piotr Jankowski ◽  
Maciej Banach ◽  
Jolanta Małyszko ◽  
Mirosław Mastej ◽  
Andrzej Tykarski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Multiple Imputation ◽  
Alcohol Intake ◽  
Antihypertensive Drugs ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Raising Awareness ◽  
Treatment Of Hypertension ◽  
Global Initiative

Abstract Hypertension remains the most important cardiovascular risk factor in Poland. May Measurement Month is a global initiative organized by the International Society of Hypertension aimed at raising awareness of hypertension and the need for blood pressure (BP) screening and demonstrating the potential of the opportunistic BP measurements. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in 146 sites in May 2018. Blood pressure was measured in 6450 subjects (mean age: 41 ± 15 years; 59% females). After multiple imputation, the age and sex standardized systolic and diastolic BP was 126.7/78.4 mmHg in the whole analysed group, 132.8/81.3 mmHg in subjects taking antihypertensive drugs, and 125.7/78.0 mmHg in those not taking any antihypertensive drugs. After multiple imputation, the proportions of subjects with high BP (systolic ≥140 mmHg or diastolic ≥90 mmHg or on treatment for raised BP) were 22.2% in the whole analysed group, 39.2% in subjects taking antihypertensive drugs, and 18.6% those not taking any antihypertensive drugs. Overall, hypertension was present in 32.8% of participants, among them 38.7% were not aware of the disease, 53.1% were taking antihypertensive drugs, and 32.3% had BP controlled to target (<140/90 mmHg). Blood pressure was increasing with increasing body mass index and alcohol intake. Smokers and project participants with diabetes had increased average BP. In conclusion, this project provides additional evidence for a considerable potential for further reduction of cardiovascular risk through improvement in detection and treatment of hypertension in Poland.

scholarly journals Fixed-dose combinations in the treatment of hypertension to increase adherence

2020 ◽  
Vol 25 (11) ◽  
pp. 4184
Author(s):  
T. E. Morozova ◽  
E. O. Samokhina
Keyword(s):  
Blood Pressure ◽  
Antihypertensive Drugs ◽  
Fixed Dose ◽  
Optimal Solutions ◽  
Comorbid Conditions ◽  
Treatment Regimens ◽  
Wide Range ◽  
Treatment Of Hypertension ◽  
Artery Disease ◽  
Initiation Of Therapy

Despite a wide range of antihypertensive drugs, blood pressure (BP) control often remains unsatisfactory, and every year the number of people with uncontrolled high BP increases. One of the strategies aimed at improving medical adherence is the use of fixed-dose combinations of 2 antihypertensive drugs for starting therapy, and, if necessary, 3 drugs. Initiation of therapy with 2 drugs in one tablet is recommended for most patients. A review of algorithms for choosing combinations of antihypertensive drugs in different clinical situations, including in patients with various comorbid conditions, is presented. Simplification of treatment regimens makes it possible to choose the most optimal solutions in various clinical situations, in particular, with stage I-II hypertension, with a combination of hypertension with chronic kidney disease, as well as with a combination of hypertension with coronary artery disease and a number of other diseases.

scholarly journals Clinical-pharmacological priorities in the election of blockators of the renin-angiotenzine system and diuretics in patients with uncompleted hypertension

2017 ◽  
Vol 14 (2) ◽  
pp. 75-79
Author(s):  
A I Ponomareva ◽  
G G Ketova ◽  
O G Kompaniets
Keyword(s):  
Clinical Practice ◽  
Arterial Hypertension ◽  
Ace Inhibitors ◽  
Antihypertensive Medication ◽  
Antihypertensive Drugs ◽  
National Guidelines ◽  
Good Tolerability ◽  
Wide Range ◽  
Treatment Of Hypertension ◽  
Efficacy Studies

The article discusses the problem of using ACE inhibitors and diuretics in arterial hypertension. Analysis of the position of doctors when prescribing ACE inhibitors and diuretics showed its compliance with current national guidelines for the treatment of hypertension. Physicians use more adequate criteria for antihypertensive drugs usage. There were no non-rational use of diuretics in combination, regardless of indications and contraindications. If there are indications for the use of a diuretic and a preparation of ACE inhibitors, you have to make greater use of fixed combinations of drugs. The article discusses the results of clinical efficacy studies of perindopril and indapamide in clinical practice. Noliprel® forte is an effective antihypertensive medication, not only reducing BP, but also organoprotective aim and good tolerability in wide range of patients with arterial hypertension.

scholarly journals Fixed combination of lercanidipine with enalapril - pharmacological features, clinical feasibility, advantages in the treatment of hypertension

2021 ◽  
pp. 21-24
Author(s):  
P. О. Lazarev
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Arterial Hypertension ◽  
Fixed Combination ◽  
Antihypertensive Drugs ◽  
Mechanisms Of Action ◽  
High Efficacy ◽  
National Guidelines ◽  
Treatment Of Hypertension ◽  
And Oxidative Stress

According to current international and national guidelines for the management of arterial hypertension preference is given to the use of fixed combinations of antihypertensive drugs of different classes, thus increasing the effectiveness of therapy acting in a complementary manner to affect different pathogenic mechanisms of arterial hypertension and reducing the frequency of side effects. A fixed combination of lercanidipine and enalapril contains antihypertensive drugs that have complementary mechanisms of action. This combination effectively reduces blood pressure, has high efficacy and tolerability, it may provide an additive effect on macro- and microvascular structures, arterial stiffness and oxidative stress. It has a beneficial influence on renal function, especially in patients with comorbidities.

scholarly journals Consumption of antihypertensive drugs dispensed under the pharmacy benefit management program

2011 ◽  
Vol 47 (4) ◽  
pp. 807-815
Author(s):  
Aline Pereira Rocha ◽  
Brigitte Rieckmann Martins dos Santos
Keyword(s):  
Antihypertensive Drugs ◽  
Patient Adherence ◽  
Age Groups ◽  
Management Program ◽  
Age Group ◽  
Pharmacy Benefit Management ◽  
Antihypertensive Medications ◽  
Pharmacy Benefit ◽  
Treatment Of Hypertension ◽  
The Mean

Pharmacy benefit management (PBM) programs provide attractive discounts for drug purchase, a relevant measure to address costs, mainly of drugs for the treatment of chronic diseases. This study investigated whether PBM may be used as a tool to provide information about the use of antihypertensive medications when they are purchased. The profile of medicines taken to treat high blood pressure by large IT company employees and their dependents was evaluated from January to December 2009. The mean rate of drug boxes purchased to control hypertension was 9.4 ± 10.0 in 2009. Men purchased more drugs than women. The number of drugs purchased for the treatment of hypertension was lower than expected in all age groups except for individuals aged 54-58 and >59 years. Among men, the purchase of drugs to treat hypertension was higher than expected in the 24-28, 34-38 and 54-58 age groups. Among women, results matched expectations, except for the age group 34-38 years, in which purchase was lower than expected. Individuals in the age group 0-18 years were found to consume antihypertensive drugs. Although the PBM system may be used to identify drugs purchased by users, it does not ensure patient adherence to recommended drug treatment to control hypertension.

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