scholarly journals On the explanation of the acidic pH requirement for in vitro activity of colicin E1. Site-directed mutagenesis at Glu-468.

1987 ◽  
Vol 262 (29) ◽  
pp. 14273-14281
Author(s):  
J W Shiver ◽  
W A Cramer ◽  
F S Cohen ◽  
L J Bishop ◽  
P J de Jong
Keyword(s):  
Site Directed Mutagenesis ◽  
Vitro Activity ◽  
Directed Mutagenesis ◽  
Acidic Ph ◽  
In Vitro Activity ◽  
Colicin E1

scholarly journals Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest

2019 ◽  
Vol 63 (12) ◽  
Author(s):  
Kay B. Barnes ◽  
Steven D. Zumbrun ◽  
Stephanie A. Halasohoris ◽  
Purvi D. Desai ◽  
Lynda L. Miller ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Bacterial Strain ◽  
Low Ph ◽  
Vitro Activity ◽  
Antimicrobial Efficacy ◽  
Acidic Ph ◽  
In Vitro Activity ◽  
Broth Microdilution

ABSTRACT This study investigated the in vitro activity of finafloxacin against bacterial strain panels of the biodefense pathogens. Broth microdilution assays were performed at neutral and acidic pH to determine the effectiveness of the antibiotics under conditions typical of an intracellular environment. In all instances, finafloxacin demonstrated superior activity at low pH. These results highlight the importance of evaluating antimicrobial efficacy under conditions relevant to those encountered in vivo.

In Vitro Activity of Phytocannabinoids from High Potency Cannabis sativa

Planta Medica ◽  
2012 ◽  
Vol 78 (05) ◽  
Author(s):  
A Husni ◽  
S Ross ◽  
O Dale ◽  
C Gemelli ◽  
G Ma ◽  
...  
Keyword(s):  
Cannabis Sativa ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
High Potency
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