scholarly journals Molecular Forms and Subunit Composition of a Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein Kinase Purified from Bovine Heart Muscle

1972 ◽  
Vol 247 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Charles S. Rubin ◽  
Jack Erlichman ◽  
Ora M. Rosen
Keyword(s):  
Protein Kinase ◽  
Heart Muscle ◽  
Subunit Composition ◽  
Molecular Forms ◽  
Dependent Protein Kinase ◽  
Bovine Heart ◽  
Dependent Protein

scholarly journals The inhibitor protein of the cyclic AMP-dependent protein kinase-catalytic subunit interaction. Composition of multiple complexes

1988 ◽  
Vol 256 (3) ◽  
pp. 785-789 ◽  
Author(s):  
S M Van Patten ◽  
A Hotz ◽  
V Kinzel ◽  
D A Walsh
Keyword(s):  
Protein Kinase ◽  
Cyclic Amp ◽  
Catalytic Subunit ◽  
Inhibitor Protein ◽  
Multiple Forms ◽  
Subunit Interaction ◽  
Dependent Protein Kinase ◽  
Bovine Heart ◽  
Dependent Protein ◽  
Multiple Species

It has been previously demonstrated that the combination of pure preparations of the inhibitor protein of the cyclic AMP-dependent protein kinase and the catalytic subunit of this enzyme resulted in the formation of multiple complexes [Van Patten, Fletcher & Walsh (1986) J. Biol. Chem. 261, 5514-5523]. In the present study it is demonstrated that these multiple species occur because the bovine heart protein kinase preparation contains multiple forms of catalytic subunit [Kinzel, Hotz, König, Gagelmann, Pyerin, Reed, Köbler, Hofmann, Obst, Gensheimer, Goldblatt & Shaltiel (1987) Arch. Biochem. Biophys. 253, 341-349].

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