Characterization of polychlorinated aromatic hydrocarbons by reversed-phase liquid chromatography with ultraviolet absorbance and mass spectrometric detection

2003 ◽  
Vol 1016 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Yin Peng ◽  
Su-Yuan Xie ◽  
Meng Chen ◽  
Yu-Qi Feng ◽  
La-Jia Yu ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Aromatic Hydrocarbons ◽  
Reversed Phase ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Reversed Phase Liquid Chromatography ◽  
Ultraviolet Absorbance ◽  
Phase Liquid ◽  
Polychlorinated Aromatic Hydrocarbons

Determination of nifedipine in serum or plasma by reversed-phase liquid chromatography.

1983 ◽  
Vol 29 (7) ◽  
pp. 1344-1348 ◽  
Author(s):  
P R Bach
Keyword(s):  
Liquid Chromatography ◽  
Reversed Phase ◽  
Extraction Column ◽  
Phase Extraction ◽  
Reversed Phase Liquid Chromatography ◽  
Ultraviolet Absorbance ◽  
Standard Curve ◽  
Coefficients Of Variation ◽  
Phase Liquid

Abstract Therapeutic concentrations of nifedipine in serum or plasma were measured by reversed-phase liquid chromatography, with detection by ultraviolet absorbance at 235 nm. In the procedure a disposable reversed-phase extraction column is used. A 1-mL sample is required. The method is sensitive to 3 micrograms of nifedipine per liter and the standard curve is linear to at least 400 micrograms/L. Coefficients of variation at 100 micrograms/L were 2.2% within-run, 2.8% between-run. The method has been used to determine nifedipine in patients involved in a test of its efficacy in treating muscular dystrophy.

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