PO10-TU-45 First case report of Mitoxantrone (MTX) treatment and response in Thai multiple sclerosis (MS) patients

Background: Cladribine is an antimetabolite used for the treatment of relapsing–remitting multiple sclerosis. At present, there are no data available on its use in breastfeeding mothers and its transfer in human milk. Objective: We present a case of a lactating mother who donated her milk samples to study the transfer of cladribine following a 20-mg oral dose. Methods: Analysis was done using liquid chromatography–mass spectrometry. Results: The relative infant dose calculated in this study was 3.06%. Conclusion: This is the first case report suggesting the transfer of cladribine in human milk in measurable quantities. However, caution should be advised during lactation.

Download Full-text

Multiple sclerosis (MS) and leprosy: First case report and literature review

Journal of the Neurological Sciences ◽

10.1016/j.jns.2017.08.2537 ◽

2017 ◽

Vol 381 ◽

pp. 901

Author(s):

T. Ribeiro

Keyword(s):

Multiple Sclerosis ◽

Case Report ◽

Literature Review ◽

First Case

Download Full-text

Sudden cardiac death in multiple sclerosis caused by active demyelination of the medulla oblongata

Multiple Sclerosis Journal ◽

10.1177/1352458511408476 ◽

2011 ◽

Vol 17 (9) ◽

pp. 1146-1148 ◽

Cited By ~ 14

Author(s):

GJD Hengstman ◽

B Kusters

Keyword(s):

Multiple Sclerosis ◽

Case Report ◽

Sudden Cardiac Death ◽

Medulla Oblongata ◽

Cardiac Death ◽

Sudden Onset ◽

Cardiac Arrythmias ◽

First Case ◽

Relapsing Remitting ◽

Demyelinating Lesions

Cardiovascular autonomic dysfunction is not uncommon in multiple sclerosis (MS) and is related to the involvement of the vegetative areas of cardiac innervations in the medulla oblongata. It has been suggested that this may contribute to the occurrence of sudden death in MS. In this case report, we present a patient with active relapsing–remitting MS who died unexpectedly due to the sudden onset of cardiac arrythmias. Post-mortem examination showed the presence of active demyelinating lesions in the medulla oblongata. As far as we know, this is the first case report clearly linking sudden cardiac death to active MS on the histopathological level.

Download Full-text

Case Report: Clinical and Imaging Characteristics of a Patient with Anti-flotillin Autoantibodies: Neuromyelitis Optica or Multiple Sclerosis?

Frontiers in Immunology ◽

10.3389/fimmu.2021.808420 ◽

2021 ◽

Vol 12 ◽

Author(s):

Ke Shang ◽

Chang Cheng ◽

Chuan Qin ◽

Jun Xiao ◽

Gang Deng ◽

...

Keyword(s):

Multiple Sclerosis ◽

Case Report ◽

Neuromyelitis Optica ◽

Clinical Reasoning ◽

Clinical Course ◽

Case Summary ◽

First Case ◽

Imaging Characteristics

BackgroundDemyelination diseases are complex puzzles that are not always straightforward to diagnose. Multiple sclerosis and neuromyelitis optica are two that are frequently encountered. Numerous autoantibodies newly discovered in recent years have significantly aided clinical reasoning and diagnosis in differentiating demyelination disorders. Here we report a case of demyelination disease with anti-flotillin autoantibodies positive, which is not common in past references.Case summaryThe patient presented with characteristic neuromyelitis optica symptoms and had remission and relapse. But his images exhibited characteristics of both neuromyelitis optica spectrum illness and multiple sclerosis.ConclusionThis is the first case report describing the clinical course and imaging characteristics of demyelination illness associated with anti-flotillin autoantibodies. Although so far it appears to be a subtype of multiple sclerosis, there is still a potential that it is separate from MS and NMOSD.

Download Full-text

Onychomycosis Caused by Kloeckera apiculata: A Case Report in a Patient with Multiple Sclerosis

Skin Appendage Disorders ◽

10.1159/000518046 ◽

2021 ◽

pp. 1-4

Author(s):

Carlos Daniel Sánchez-Cárdenas ◽

Diana Carolina Vega-Sánchez ◽

Tania Rosalia González-Suárez ◽

José Flores-Rivera ◽

Roberto G. Arenas ◽

...

Keyword(s):

Multiple Sclerosis ◽

Case Report ◽

Microscopic Examination ◽

Causal Agent ◽

Kloeckera Apiculata ◽

Sabouraud Agar ◽

Maldi Tof ◽

First Case

We report the first case of onychomycosis caused by <i>Kloeckera apiculata</i> in a woman with multiple sclerosis. Video-dermoscopic examination showed a spiked pattern and distal irregular aspect. Colonies on Sabouraud agar were white, creamy, and smooth. A microscopic examination showed blastoconidia. MALDI-TOF confirmed <i>Kloeckera apiculata</i> as the causal agent.

Download Full-text

Very Rare Case Report of Multiple Sclerosis in a Case of Chronic Kidney Disease

Journal of Clinical Case Studies Reviews & Reports ◽

10.47363/jccsr/2020(2)145 ◽

2020 ◽

Vol 2 (5) ◽

pp. 1-4

Author(s):

Vajed Mogal ◽

◽

Mahendra Wawhal ◽

Keyword(s):

Multiple Sclerosis ◽

Chronic Kidney Disease ◽

Case Report ◽

Kidney Disease ◽

Optic Neuritis ◽

World Literature ◽

Oligoclonal Bands ◽

Unknown Etiology ◽

First Case ◽

Acute Optic Neuritis

Multiple sclerosis is a neurological disease, which affects young adults. Its course is unpredictable and runs over decades. It is considered as disease of unknown etiology in which there is demyelination of the brain and spinal cord. There is one case report of membranous GN in a case of progressive multiple sclerosis in the extant world literature. We report here perhaps the first case in the world of the occurrence of multiple sclerosis in a known case of chronic kidney disease with the presentation of acute optic neuritis, having a characteristics picture on MRI of multiple sclerosis in brain, abnormal VEP, oligoclonal bands in CSF and a prior episode of acute optic neuritis 3 years back. In our opinion, this case opens the flood gates for research & work to investigate whether the oxidative stress and the smouldering proinflammatory state in CKD can precipitate multiple sclerosis in a genetically predisposed host in a given environment. Multiple Sclerosis is often associated with a neurogenic bladder, but renal function is generally considered to be normal.

Download Full-text

Reversible cerebral vasoconstriction syndrome associated with interferon beta-1a use for multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458516641774 ◽

2016 ◽

Vol 22 (12) ◽

pp. 1626-1628 ◽

Cited By ~ 3

Author(s):

Tamara Strohm ◽

Burhan Chaudhry ◽

Mary A Willis ◽

Steven Shook

Keyword(s):

Multiple Sclerosis ◽

Case Report ◽

Subarachnoid Hemorrhage ◽

Cerebral Angiography ◽

Interferon Beta ◽

Acute Onset ◽

Severe Headache ◽

Reversible Cerebral Vasoconstriction Syndrome ◽

Cerebral Vasoconstriction ◽

First Case

Background: Reversible cerebral vasoconstriction syndrome (RCVS) has been associated with multiple medications, cocaine, pregnancy, migraine, and other conditions. Objectives: RCVS associated with interferon beta use has never before been described. Methods: We describe the case of a 20-year-old female who developed acute onset severe headache and was found to have subarachnoid hemorrhage 2 months after initiating Rebif (Interferon beta-1a) for multiple sclerosis (MS). Cerebral angiography showed multiple areas of distal stenosis and dilatation with radiographic resolution 1 month later. Results/conclusions: This is the first case report of RCVS in an MS patient treated with Rebif.

Download Full-text