INCREASED EXPRESSION OF NUCLEOPHOSMIN IS ASSOCIATED WITH WORSE PATHOLOGICAL FEATURES AND PREDICTS INTRAVESICAL RECURRENCE IN PATIENTS WITH BLADDER CANCER

2008 ◽  
Vol 179 (4S) ◽  
pp. 318-318
Author(s):  
Keiichi Ito ◽  
Shinobu Noji ◽  
Takako Asano ◽  
Shusei Ikegami ◽  
Hidehiko Yoshii ◽  
...  
2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 111-111
Author(s):  
Kotaro Obayashi

111 Background: Although previous studies have reported that the incidence of metachronous bladder cancer (MBC) is not significantly different after brachytherapy (BT) compared to radical prostatectomy (RP), few studies have reported differences in the pathological features (PF) of MBC between them. This study was conducted to clarify differences in the incidence and PF of MBC between BT and RP in our hospital. Methods: We reviewed 504 patients treated with BT and 471 referred patients treated with RP from 2006 to 2017 in our hospital. We checked the incidence of MBC in all patients and examined the PF including the tumor number, location within the bladder, histology, and time from BT or RP to the occurrence. The chi-square test and Mann-Whitney U test were performed to analyze the differences between the two groups. Results: After a median follow-up time of 66 months, a total of 8 cases of BC occurred in the BT group (1.6 %) and 5 in the RP group (1.1 %). The median time from initial treatment to the occurrence of MBC was 56 months (12-121) in BT and 71 months (4-126) in RP (p = 0.622). Average tumor number was not significantly different (BT:1.38, RP: 2.2, p = 0.265). The incidence of MBC in each location within the bladder for BT vs. RP was 4 vs 0 in the right wall, 3 vs 0 in the left wall, 0 vs 3 in the posterior wall, 0 vs 2 in the dome, and 1 vs 0 in the trigone. The incidence in the lateral wall was significantly higher in BT than in RP (p = 0.00466). There were 3 muscle-invasive cases in BT and 1 case in RP (p = 1.00). High-grade urothelial cancer occurred more in BT 8 than in RP 1 (p = 0.00699). Conclusions: The risk of MBC after BT appeared to be equivalent to patients after RP. MBC after BT occurred more in the lateral wall with worse PF compared to those after RP.


2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Kazumasa Matsumoto ◽  
Toshihide Matsumoto ◽  
Takefumi Satoh ◽  
Masatsugu Iwamura ◽  
Yuichi Sato ◽  
...  

2021 ◽  
Vol 10 (3) ◽  
pp. 1521-1529
Author(s):  
Gaetano Aurilio ◽  
Alessia Cimadamore ◽  
Antonio Lopez-Beltran ◽  
Marina Scarpelli ◽  
Francesco Massari ◽  
...  

2013 ◽  
Vol 30 (3) ◽  
pp. 1073-1080 ◽  
Author(s):  
HIDEHIKO YOSHII ◽  
KEIICHI ITO ◽  
TAKAKO ASANO ◽  
AKIO HORIGUCHI ◽  
MASAMICHI HAYAKAWA ◽  
...  

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xi Tu ◽  
Neng Zhang ◽  
Xiyao Zhuang ◽  
Shulian Chen ◽  
Xu Luo

Abstract Background Nonfunctional bladder paragangliomas is a rare urological disease. It may present clinical, radiology and pathological features similar to bladder cancer, Only scarce reports have been reported. Urologist must identify this generally benign neuroendocrine neoplasm to avoid misdiagnosis. Case presentation A 62-year-old female presented the outpatient department of our hospital with the symptoms of stomachache, frequent micturition, and urination pain for 20 days. Diagnosed with high blood pressure 1 year ago, administered Amlodipine besylate tablets 5 mg po qd occasionally, did not check blood pressure; denied any tumor observation in the family history. Color ultrasound of the urinary system showed a 38 mm × 34 mm hypoechoic mass on the right side of the bladder, CDFI: in the masses, blood supply was sufficient. Cystoscope showed bladder occupying lesion. Biopsy diagnosis: papillary polypoid cystitis was suspected as a malignant change (Fig. 3a). Then, the patient was admitted to our urological department. Further, computer tomography urography considered bladder cancer. Cystoscopy and biopsy failed to define the nature of the lesions in our outpatient department, which prompted a transurethral resection of the bladder tumor. histopathological and immunohistochemical results were diagnosed as bladder paragangliomas. For the reason, the tumor was removed by partial resection of the bladder. The postoperative recovery and follow-up were uneventful. Conclusions Nonfunctional bladder paragangliomas are occasionally found on imaging studies with the symptoms of urinary tract infection or/and intermittent painless hematuria. It may present clinical, radiology and pathological features similar to bladder cancer, so knowledge of this generally benign neuroendocrine neoplasm is of great importance to avoid misdiagnosis. It should be accompanied by the clinical and pathological characteristics of the patient and image changes. Partial resection of the bladder can effectively treat this disease.


Author(s):  
Hüseyin Alperen Yıldız ◽  
Dogan Deger ◽  
Guven Aslan

Purpose: To assess the ability of urology residents and experienced urologists to accurately predict pathological features of bladder tumors based solely on cystoscopic appearance, and evaluate how accurately urologists can decide eligible patients for postoperative intravesical chemotherapy. Methods: 104 patients with bladder mass were included, 7 senior urologists and 4 residents joined the study. Before resection, both specialists and residents were asked to predict the stage, grade of the tumor, and presence of CIS. We obtained resident predictions for 104 patients and senior predictions for 72 of these patients. Based on these predictions, eligibility of the patients for single postoperative immediate chemotherapy were determined according to EAU NMIBC guidelines. After final pathology report, risk scores recalculated and compared with surgeons’ predictions. Results: In correlation analysis, strong agreement with the pathological report could not be demonstrated with any of the stages, grades, and presence of CIS for both senior and resident urologists. Urology residents’ predictions were slightly more accurate than the senior urologists’. According to senior urologists’ predictions, 14/72 (19,4%) of the patients, and according to residents’ predictions, 19/104 (18,2%) of the patients were found to be either overtreated or undertreated. Conclusions: Cystoscopic visual prediction is not sufficient to decide on immediate postoperative intravesical chemotherapy regardless of the experience, and we need more objective parameters to improve the appropriate patient selection. What’s known: In patients with non-muscle invasive bladder cancer (NMIBC), decision of immediate postoperative chemotherapy instillation is made by urologists according to clinical and “presumed” pathological parameters as definitive pathology is unkown. Therefore, the concordance of this presumption with the final pathology is important. What’s new: In our study, we demonstrated that urologists’ predictions on pathological features are not reliable to decide on immediate postoperative intravesical chemotherapy instillation and better criteria for patient selection are needed.


2013 ◽  
Vol 12 (1) ◽  
pp. e232-e233 ◽  
Author(s):  
B. Miñana ◽  
J.M. Cozar ◽  
J. Palou ◽  
R. Medina ◽  
J. Subirá ◽  
...  

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