Evidence for Testicular Impairment After Long-Term Treatment with a Luteinizing Hormone-Releasing Hormone Agonist in Elderly Men

1989 ◽  
Vol 142 (5) ◽  
pp. 1235-1238 ◽  
Author(s):  
Andrea U. Decensi ◽  
Domenico Guarneri ◽  
Paola Marroni ◽  
Liborio Di Cristina ◽  
Michela Paganuzzi ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Term Treatment ◽  
Elderly Men ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Long Term Treatment ◽  
Testicular Impairment

Long-Term Treatment of Central Precocious Puberty with a Long-Acting Analogue of Luteinizing Hormone-Releasing Hormone

1983 ◽  
Vol 309 (21) ◽  
pp. 1286-1290 ◽  
Author(s):  
M.Joan Mansfield ◽  
Donna E. Beardsworth ◽  
Jacquelyn S. Loughlin ◽  
John D. Crawford ◽  
Hans H. Bode ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Term Treatment ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Long Term Treatment ◽  
Long Acting

Chronic treatment with [D-Ala6, des Gly-]-LHRH ethylamide reversibly delays puberty in the female rat

1984 ◽  
Vol 62 (7) ◽  
pp. 853-855 ◽  
Author(s):  
Kathleen M. Landymore ◽  
Michael Wilkinson
Keyword(s):  
Luteinizing Hormone ◽  
Sexual Development ◽  
Chronic Treatment ◽  
Term Treatment ◽  
Female Rat ◽  
Lhrh Agonist ◽  
Maturation Period ◽  
Luteinizing Hormone Releasing Hormone ◽  
Long Term Treatment

Luteinizing hormone-releasing hormone (LHRH) agonist analogs have been suggested as a useful treatment for precocious puberty, though there is some concern that long-term treatment might be deleterious to normal sexual development. We have taken advantage of the very short maturation period of the female rat (approximately 35 days from birth) to examine the effects of chronic (daily) treatment with [D-Ala6, des Gly-[Formula: see text]]-LHRH ethylamide. We have observed that this treatment (either 1 or 2 μg/day) from day 5 after birth significantly delays sexual maturation but does not affect subsequent sexual cycles.

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