Inhibitory Effects of Long Term Treatment with a Luteinizing Hormone-Releasing Hormone Agonist on the Pituitary-Gonadal Axis in Male and Female Rats

Endocrinology ◽  
1979 ◽  
Vol 104 (5) ◽  
pp. 1369-1376 ◽  
Author(s):  
LIONEL CUSAN ◽  
CLAUDE AUCLAIR ◽  
ALAIN BELANGER ◽  
LOUISE FERLAND ◽  
PAUL A. KELLY ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Term Treatment ◽  
Female Rats ◽  
Inhibitory Effects ◽  
Male And Female ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Male And Female Rats ◽  
Long Term Treatment

Evidence for Testicular Impairment After Long-Term Treatment with a Luteinizing Hormone-Releasing Hormone Agonist in Elderly Men

1989 ◽  
Vol 142 (5) ◽  
pp. 1235-1238 ◽  
Author(s):  
Andrea U. Decensi ◽  
Domenico Guarneri ◽  
Paola Marroni ◽  
Liborio Di Cristina ◽  
Michela Paganuzzi ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Term Treatment ◽  
Elderly Men ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Long Term Treatment ◽  
Testicular Impairment

Long-Term Treatment of Central Precocious Puberty with a Long-Acting Analogue of Luteinizing Hormone-Releasing Hormone

1983 ◽  
Vol 309 (21) ◽  
pp. 1286-1290 ◽  
Author(s):  
M.Joan Mansfield ◽  
Donna E. Beardsworth ◽  
Jacquelyn S. Loughlin ◽  
John D. Crawford ◽  
Hans H. Bode ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Term Treatment ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Long Term Treatment ◽  
Long Acting

EFFECT OF SMALL DOSES OF OESTRADIOL BENZOATE ON PITUITARY PRODUCTION AND RELEASE OF I. C. S. H. IN GONADECTOMIZED MALE AND FEMALE RATS

1962 ◽  
Vol 39 (2) ◽  
pp. 245-252 ◽  
Author(s):  
E. Gans ◽  
G. P. van Rees
Keyword(s):  
Term Treatment ◽  
Female Rats ◽  
Male Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Long Term Treatment ◽  
Oestradiol Benzoate ◽  
Small Doses ◽  
Higher Doses

ABSTRACT The influence on the I. C. S. H.-content of the pituitary gland and the blood serum of long-term treatment of gonadectomized male and female rats with several low doses of oestradiol benzoate was investigated. It was found that only in females treatment with 0.1 and 0.2 μg of oestradiol benzoate daily results in an increase of the pituitary I. C. S. H.-content, whereas in the serum content a (non-significant) decrease was observed. In male rats the pituitary I. C. S. H.-content was not influenced by treatment with these doses, but the serum content decreased. Higher doses of oestradiol (0.5 and 2.0 μg daily) caused, both in males and in females, a decrease of the I. C. S. H.-content in the hypophysis as well as in the serum. It is assumed that oestrogen, if chronically administered, exerts two different actions on pituitary I. C. S. H.: it depresses the production of I. C. S. H. and inhibits the release. In females, these two effects have different threshold levels, that for the release being the lower one. In males the threshold for the inhibition of production has to be lower.

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