Bilateral Pelvic Lymphadenectomy and Radical Prostatectomy for Clinical Stage C Prostatic Cancer: Role of Adjuvant Treatment for Residual Cancer and in Disease Progression

1986 ◽  
Vol 135 (6) ◽  
pp. 1199-1205 ◽  
Author(s):  
Horst Zincke ◽  
David C. Utz ◽  
William F. Taylor
Keyword(s):  
Radical Prostatectomy ◽  
Disease Progression ◽  
Adjuvant Treatment ◽  
Prostatic Cancer ◽  
Clinical Stage ◽  
Pelvic Lymphadenectomy ◽  
Residual Cancer

Postoperative Adjuvant Chemotherapy for Node-Positive Cervical Adenocarcinoma

2009 ◽  
Vol 19 (2) ◽  
pp. 277-280 ◽  
Author(s):  
Nobuhiro Takeshima ◽  
Kuniko Utsugi ◽  
Katsuhiko Hasumi ◽  
Ken Takizawa
Keyword(s):  
Adjuvant Chemotherapy ◽  
Clinical Stage ◽  
Disease Free Survival ◽  
Pelvic Lymphadenectomy ◽  
Cervical Adenocarcinoma ◽  
Postoperative Chemotherapy ◽  
Postoperative Adjuvant Chemotherapy ◽  
Free Survival ◽  
Node Positive

We examined the effectiveness of postoperative adjuvant chemotherapy for node-positive cervical adenocarcinoma. During the period from 1994 to 2002, 98 consecutive patients with clinical stage I and II cervical adenocarcinoma were treated surgically without having undergone any prior treatment. Surgical procedures included radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy. Postoperatively, 21patients were found to have lymph node metastasis, and all were treated with chemotherapy in the absence of radiotherapy. All patients were followed up for at least 5 years. Recurrence developed in 9 of the 21 patients, all 9died of the disease. Six of the 9 recurrences were extrapelvic lesions. Five-year disease-free survival and overall survival were 57% and 67%, respectively. Recurrence was more common in patients with 6 or more positive nodes than in those with fewer than 3 positive nodes. These data suggest the potential role of postoperative chemotherapy for treatments of cervical adenocarcinoma. However, the effectiveness of chemotherapy alone in node-positive cervical adenocarcinoma was likely not as high as that in squamous cell carcinoma. Despite our use of postoperative chemotherapy in the absence of pelvic radiation, the disease recurred predominantly at distant sites.

scholarly journals Role of Changes in Magnetic Resonance Imaging or Clinical Stage in Evaluation of Disease Progression for Men with Prostate Cancer on Active Surveillance

2020 ◽  
Vol 77 (4) ◽  
pp. 501-507 ◽  
Author(s):  
Gregory T. Chesnut ◽  
Emily A. Vertosick ◽  
Nicole Benfante ◽  
Daniel D. Sjoberg ◽  
Jonathan Fainberg ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Prostate Cancer ◽  
Magnetic Resonance ◽  
Disease Progression ◽  
Active Surveillance ◽  
Clinical Stage ◽  
Resonance Imaging

scholarly journals Prognostic factors and the role of pelvic lymphadenectomy in uterine leiomyosarcomas

2019 ◽  
Vol 7 ◽  
pp. 205031211985681
Author(s):  
Tounsi Nesrine ◽  
Zemni Ines ◽  
Nawel Abdelwahed ◽  
Ayadi Mohamed Ali ◽  
Boujelbene Nadia ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Clinical Stage ◽  
Menopausal Status ◽  
Disease Free Survival ◽  
Pelvic Lymphadenectomy ◽  
Free Survival ◽  
Disease Free ◽  
Lymphovascular Space Invasion

Objectives: Leiomyosarcomas are relatively rare uterine smooth muscle tumors. Surgery is the most common therapy choice for uterine leiomyosarcomas. However, controversy exists over the appropriate initial surgical management, especially about the role of lymph node sampling. The aim of our study is to analyze the prognostic factors and the role of lymphadenectomy in overall survival and in disease-free survival. Methods: We analyzed retrospectively 31 patients suffering from uterine leiomyosarcomas at Institute of Salah Azaiez during 2000–2014. Demographic and clinical features such as age, menopausal status, stage, tumor size, and management options were examined, and pathological characteristics such as mitotic count, lymphovascular space invasion, and tumor necrosis were evaluated. Results: Out of 31 patients treated for uterine leiomyosarcomas, pelvic lymphadenectomy was done for 18 patients. No para-aortic lymphadenectomy was performed. Median number of resected lymph nodes was 13 ± 7 (range: 3–27). Lymphatic metastasis was observed in 2 out of 18 patients with clinical stage IA and IIIB. The distribution of different variables (age, International Federation of Gynecology and Obstetrics stage, tumor size, mitotic count, and adjuvant treatment) between the group of patients, who had or had not lymphadenectomy done, had no significant difference. The 5-year overall survival and disease-free survival were 61% and 50%, respectively. Clinical stage, presence of lymphovascular space invasion, and lymph nodal dissection were found to be relevant for disease-free survival on univariate analysis. Only age and menopausal status were found to be a prognostic factor for overall survival. Conclusion: Hence, routine lymph node dissection was not generally recommended. Our study demonstrates that lymphadenectomy has a statistically significant effect on disease-free survival but not on overall survival.

Linfadenectomia laparoscopica e Mini-lap: Attualità, limiti ed indicazioni

1995 ◽  
Vol 62 (4) ◽  
pp. 553-557
Author(s):  
S. Callari ◽  
R. Bertè ◽  
P. Guaitoli ◽  
L. Zappalà ◽  
G. Mazza
Keyword(s):  
Radical Prostatectomy ◽  
Prostatic Cancer ◽  
Prostatic Carcinoma ◽  
Cancer Staging ◽  
Pelvic Lymphadenectomy ◽  
International Literature ◽  
Accuracy Rate ◽  
General Applicability ◽  
Node Metastasis ◽  
Laparoscopic Pelvic Lymphadenectomy

The authors, according to their preliminary experience with laparoscopic lymphadenectomy and Mini-lap performed for the staging of 15 patients with prostatic carcinoma, have compared the morbidity, the diagnostic accuracy rate and costs of these two techniques, referring critically to international literature and evaluating the real efficacy of a delayed laparoscopic pelvic lymphadenectomy prior to radical prostatectomy. Moreover they have tested the general applicability of the equation by Roach et al., which was empirically derived from a nomogram reported by Partin et al., to predict the risk of lymph node metastasis, applying it to a selected group of patients who underwent radical prostatectomy from 1992 to 1994 in order to maximize the utility of lymphadenectomy for prostatic cancer staging.

Laparoscopic pelvic lymphadenectomy

1992 ◽  
Vol 59 (1_suppl) ◽  
pp. 9-10
Author(s):  
G. Bianchi ◽  
C. Tallarigo ◽  
S. Cavalleri ◽  
D. Schiavone ◽  
P. Beltrami ◽  
...  
Keyword(s):  
Lymph Node ◽  
Radical Prostatectomy ◽  
Surgical Technique ◽  
Lymph Node Dissection ◽  
Prostatic Cancer ◽  
Pelvic Lymphadenectomy ◽  
Pelvic Lymph Node Dissection ◽  
Node Dissection ◽  
Laparoscopic Pelvic Lymphadenectomy ◽  
The One

From March ‘92 we have introduced laparoscopic pelvic lymphadenectomy as an aid in staging prostatic cancer. In these patients precise lymph node dissection represents an important parameter for therapeutical decision. As regards this problem, up to now, the only efficacious technique was surgical lymphadenectomy. Pelvic lymph node dissection is usually considered to be part of a preliminary operation during radical prostatectomy, but it seems to be an extreme procedure regarding its pure staging finality. For these reasons we believe that laparoscopic lymphadenectomy represents a surgical technique destined to obtain much agreement between urologists. The technique we practise is very similar to the one described by Schuessler et al. Advantages of endosurgical lymph node dissection are mainly minor invasiveness that allows rapid recovery of the patient, together with a reduction of both postoperative morbility and hospitalization.

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