1672: Positive Family History of Prostate Cancer is Not Associated with Worse Outcomes After Radical Prostatectomy

Abstract Background To investigate the correlation between family history of prostate cancer (PCa) and survival (overall and cancer specific) in patients undergoing treatment for PCa. Methods ine thousand four hundred fifty-nine patients with PCa were extracted from the South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC) database. Diagnosis occurred after 1998 and treatment before 2014. Cox proportional-hazards modeling was used to assess the effect of family history on overall survival after adjustment for confounders (age at diagnosis, NCCN risk category and year of treatment), and with stratification by primary treatment group. Competing risks regression modelling was used to assess PCa specific mortality. Results Men with a positive family history of PCa appear to have a lower Gleason score at the time of diagnosis (50% with Gleason < 7, compared to 39% in those without family history) and be diagnosed at a lower age (64 vs 69). Men with a positive family history of PCa appear to have better overall survival outcomes (p < 0.001, log rank test). In analysis adjusting for age at diagnosis, NCCN risk category and year of treatment, family history remained a significant factor when modelling overall survival (HR 0.72 95% CI 0.55–0.95, p = 0.021). There were no significant differences in treatment subgroups of radical prostatectomy (p = 0.7) and radiotherapy (0.054). Conclusion Men with a positive family history of PCa appear to have better overall survival outcomes. This better survival may represent lead time bias and early initiation of PSA screening. Family history of PCa was not associated with different survival outcomes in men who were treated with either radical prostatectomy or radiotherapy.

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Positive family history of prostate cancer not associated with worse outcomes after radical prostatectomy

Urology ◽

10.1016/j.urology.2004.09.005 ◽

2005 ◽

Vol 65 (2) ◽

pp. 311-315 ◽

Cited By ~ 18

Author(s):

Keith L. Lee ◽

Jeffrey B. Marotte ◽

Michelle K. Ferrari ◽

John E. McNeal ◽

James D. Brooks ◽

...

Keyword(s):

Prostate Cancer ◽

Family History ◽

Radical Prostatectomy ◽

Positive Family History ◽

History Of

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Family history of prostate cancer in patients with localized prostate cancer: an independent predictor of treatment outcome.

Journal of Clinical Oncology ◽

10.1200/jco.1997.15.4.1478 ◽

1997 ◽

Vol 15 (4) ◽

pp. 1478-1480 ◽

Cited By ~ 69

Author(s):

P A Kupelian ◽

V A Kupelian ◽

J S Witte ◽

R Macklis ◽

E A Klein

Keyword(s):

Prostate Cancer ◽

Treatment Outcome ◽

Family History ◽

Treatment Modality ◽

Proportional Hazards ◽

Positive Family History ◽

Specific Antigen ◽

Tumor Stage ◽

Degree Relative ◽

History Of

PURPOSE To determine if familial prostate cancer patients have a less favorable prognosis than patients with sporadic prostate cancer after treatment for localized disease with either radiotherapy (RT) or radical prostatectomy (RP). PATIENTS AND METHODS One thousand thirty-eight patients treated with either RT (n = 583) or RP (n = 455) were included in this analysis. These patients were noted as having a positive family history if they confirmed the diagnosis of prostate cancer in a first-degree relative. The outcome of interest was biochemical relapse-free survival (bRFS). We used proportional hazards to analyze the effect of the presence of family history and other potential confounding variables (ie, age, treatment modality, stage, biopsy Gleason sum [GS], and initial prostate-specific antigen [iPSA] levels) on treatment outcome. RESULTS Eleven percent of all patients had a positive family history. The 5-year bRFS rates for patients with negative and positive family histories were 52% and 29%, respectively (P < .001). The potential confounders with bRFS rates were iPSA levels, biopsy GS, and clinical tumor stage; treatment modality and age did not appear to be associated with outcome. After adjusting for potential confounders, family history of prostate cancer remained strongly associated with biochemical failure. CONCLUSION This is the first study to demonstrate that the presence of a family history of prostate cancer correlates with treatment outcome in a large unselected series of patients. Our findings suggest that familial prostate cancer may have a more aggressive course than nonfamilial prostate cancer, and that clinical and/or pathologic parameters may not adequately predict this course.

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What is known about Prostate Cancer? Response from Men Aged 50 Years and Above in Lindi Municipal, Tanzania

Tanzania Medical Journal ◽

10.4314/tmj.v31i2.363 ◽

2020 ◽

Vol 31 (2) ◽

pp. 33-44

Author(s):

Simon Francis ◽

Obadia V. Nyongole

Keyword(s):

Prostate Cancer ◽

Family History ◽

Positive Family History ◽

Negative Attitude ◽

Cross Sectional Study ◽

Cross Sectional ◽

Adult Men ◽

History Of ◽

One Year ◽

High Level

Background: The incidence of prostate cancer in Tanzania is among the highest recorded in Africa. Prostate cancer is also the most common cancer among men aged 50 years and above in Tanzania. Our study aimed to determine the awareness, knowledge, and attitudes among adult men with age 50 years and above regarding prostate cancer.Methods: This was a cross-sectional study that included 250 adult men aged 50 years and above in Lindi municipal being purposively selected and we interviewed them by using a structured questionnaire. A stratified random sampling method was used for obtaining our participants. All men who had stayed for not less than one year in Lindi and willing to participate were enrolled in the study. These men were selected at households without screening whether or not they had taken prostate screening test or had been diagnosed with prostate cancer Quantitative data were cleaned and analyzed with SPSS version 20.Results: Majority, 216(86.7%) of our study participants were aged 50–69 years and most of them, 142(56.8%) had primary education with 93.2% of them being married. Among the study subjects 7.2% had positive family history of cancer and 195(78%) were aware of prostate cancer with source of information being mass media (62.6%). Majority of them, 63.2%, did not know the risk age group. Few, 20.8% of our participants had good knowledge while majority, 95.2% had negative attitude toward prostate cancer. We found a statistically significant association between level of education, family history and level of knowledge regarding prostate cancer with p < 0.005.Conclusion: This study revealed high level of awareness, but poor knowledge regarding prostate cancer and negative attitude toward prostate cancer among men with age ≥50 years in Lindi municipal Tanzania. Key words: Awareness, knowledge, attitude, prostate cancer.

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116 Higher incidence of patients with a positive family history of prostate cancer than expected amongst French Canadians

Radiotherapy and Oncology ◽

10.1016/s0167-8140(06)80857-1 ◽

2006 ◽

Vol 80 ◽

pp. S34-S35

Author(s):

E. Filion ◽

D. Taussky ◽

J.-P. Bahary ◽

C. Maugard

Keyword(s):

Prostate Cancer ◽

Family History ◽

Positive Family History ◽

French Canadians ◽

History Of

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Does the awareness of a positive family history of prostate cancer have an influence on screening?

European Urology Supplements ◽

10.1016/s1569-9056(03)80022-2 ◽

2003 ◽

Vol 2 (1) ◽

pp. 6

Author(s):

K. Herkommer ◽

B. Volkmer ◽

T. Paiss ◽

R. Hautmann ◽

J. Gschwend

Keyword(s):

Prostate Cancer ◽

Family History ◽

Positive Family History ◽

History Of

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No detrimental effect of a positive family history on postoperative upgrading and upstaging in men with low risk and favourable intermediate-risk prostate cancer: implications for active surveillance

World Journal of Urology ◽

10.1007/s00345-020-03485-5 ◽

2020 ◽

Author(s):

Kathleen Herkommer ◽

Nikola Maier ◽

Donna P. Ankerst ◽

Stefan Schiele ◽

Jürgen E. Gschwend ◽

...

Keyword(s):

Prostate Cancer ◽

Family History ◽

Active Surveillance ◽

Detrimental Effect ◽

Clinical Decision Making ◽

Positive Family History ◽

Low Risk ◽

Gleason Grade ◽

Intermediate Risk ◽

History Of

Abstract Purpose To assess whether a first-degree family history or a fatal family history of prostate cancer (PCa) are associated with postoperative upgrading and upstaging among men with low risk and favourable intermediate-risk (FIR) PCa and to provide guidance on clinical decision making for active surveillance (AS) in this patient population. Methods Participants in the German Familial Prostate Cancer database diagnosed from 1994 to 2019 with (1) low risk (clinical T1c–T2a, biopsy Gleason Grade Group (GGG) 1, PSA < 10 ng/ml), (2) Gleason 6 FIR (clinical T1c–T2a, GGG 1, PSA 10–20 ng/ml), and (3) Gleason 3 + 4 FIR (clinical T1c–T2a, GGG 2, PSA < 10 ng/ml) PCa who were subsequently treated with radical prostatectomy (RP) were analysed for upgrading, defined as postoperative GGG 3 tumour or upstaging, defined as pT3–pT4 or pN1 disease at RP. Logistic regression analysis was used to assess whether PCa family history was associated with postoperative upgrading or upstaging. Results Among 4091 men who underwent RP, mean age at surgery was 64.4 (SD 6.7) years, 24.7% reported a family history, and 3.4% a fatal family history. Neither family history nor fatal family history were associated with upgrading or upstaging at low risk, Gleason 6 FIR, and Gleason 3 + 4 FIR PCa patients. Conclusion Results from the current study indicated no detrimental effect of family history on postoperative upgrading or upstaging. Therefore, a positive family history or fatal family history of PCa in FIR PCa patients should not be a reason to refrain from AS in men otherwise suitable.

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