Preparation of various calcium-phosphate powders by ultrasonic spray freeze-drying technique

2000 ◽  
Vol 35 (4) ◽  
pp. 575-585 ◽  
Author(s):  
Kiyoshi Itatani ◽  
Kengo Iwafune ◽  
F.Scott Howell ◽  
Mamoru Aizawa
Keyword(s):  
Calcium Phosphate ◽  
Freeze Drying ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

scholarly journals Evaluation of Process Conditions for Ultrasonic Spray-Freeze Drying of Transglutaminase

2020 ◽  
Vol 58 (1) ◽  
pp. 38-48
Author(s):  
Hilal Isleroglu ◽  
Izzet Turker
Keyword(s):  
Enzyme Activity ◽  
Flow Rate ◽  
Freeze Drying ◽  
Desirability Function ◽  
Spherical Particles ◽  
Optimum Process ◽  
Process Conditions ◽  
Plate Temperature ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

In this study, a commercial transglutaminase enzyme was dried using an ultrasonic spray freeze drying method and the effects of the process conditions were optimized to maximize the final transglutaminase activity. Accordingly, process parameters affecting enzyme activity were selected, such as nozzle frequency (48 and 120 kHz), flow rate (2, 5 and 8 mL/min) and plate temperature for secondary drying (25, 35 and 45 °C). Moreover, the effects of different pH values (pH=2.0 and 9.0) and high temperature (80 °C) on enzyme activity, physical properties and particle morphology of transglutaminase were discussed. According to the results, transglutaminase preserved its activity despite ultrasonic spray freeze drying. Sonication enhanced the enzyme activity. Using the desirability function method, the optimum process conditions were determined to be flow rate 3.10 mL/min, plate temperature 45 °C and nozzle frequency 120 kHz. The predicted activity ratio was 1.17, and experimentally obtained ratio was 1.14±0.02. Furthermore, enzyme produced by ultrasonic spray freeze drying had low moisture values (2.92-4.36 %) at 8 h of drying. When the morphological structure of the transglutaminase particles produced by ultrasonic spray freeze drying under the optimum conditions was examined, spherical particles with pores on their surfaces were observed. In addition, flow properties of the transglutaminase powders were considered as fair under most conditions according to the Carr index.

Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying

2013 ◽  
Vol 30 (11) ◽  
pp. 2891-2901 ◽  
Author(s):  
Suzanne M. D’Addio ◽  
John Gar Yan Chan ◽  
Philip Chi Lip Kwok ◽  
Bryan R. Benson ◽  
Robert K. Prud’homme ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Aerosol Delivery ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

Inhalable clarithromycin liposomal dry powders using ultrasonic spray freeze drying

2017 ◽  
Vol 305 ◽  
pp. 63-70 ◽  
Author(s):  
Tiantian Ye ◽  
Jiaqi Yu ◽  
Qiuhua Luo ◽  
Shujun Wang ◽  
Hak-Kim Chan
Keyword(s):  
Freeze Drying ◽  
Dry Powders ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

Sinterability of Yttria-Stabilized Zirconia Powder Prepared by Ultrasonic Spray Freeze-Drying Technique

1994 ◽  
Vol 9 (4) ◽  
pp. 666-679 ◽  
Author(s):  
Shinji Iwaida ◽  
Kiyoshi Itatani ◽  
F. Scott Howell ◽  
Akira Kishioka ◽  
Makio Kinoshita
Keyword(s):  
Freeze Drying ◽  
Yttria Stabilized Zirconia ◽  
Stabilized Zirconia ◽  
Zirconia Powder ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

Microencapsulation of Microbial Transglutaminase by Ultrasonic Spray-Freeze Drying

2019 ◽  
Vol 12 (12) ◽  
pp. 2004-2017 ◽  
Author(s):  
Hilal Isleroglu ◽  
Izzet Turker ◽  
Banu Koc ◽  
Mehmet Tokatli
Keyword(s):  
Freeze Drying ◽  
Microbial Transglutaminase ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying

Constant size, variable density aerosol particles by ultrasonic spray freeze drying

2012 ◽  
Vol 427 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Suzanne M. D’Addio ◽  
John Gar Yan Chan ◽  
Philip Chi Lip Kwok ◽  
Robert K. Prud’homme ◽  
Hak-Kim Chan
Keyword(s):  
Freeze Drying ◽  
Aerosol Particles ◽  
Variable Density ◽  
Ultrasonic Spray ◽  
Constant Size ◽  
Spray Freeze Drying ◽  
Size Variable

Ultrasonic spray-freeze drying of partially purified microbial transglutaminase

2018 ◽  
Vol 111 ◽  
pp. 153-164 ◽  
Author(s):  
Hilal Isleroglu ◽  
Izzet Turker ◽  
Mehmet Tokatli ◽  
Banu Koc
Keyword(s):  
Freeze Drying ◽  
Microbial Transglutaminase ◽  
Ultrasonic Spray ◽  
Spray Freeze Drying
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