Synthesis and characterization of a functionalized biodegradable copolymer: poly(l-lactide-co-RS-β-malic acid)

Polymer ◽  
2003 ◽  
Vol 44 (4) ◽  
pp. 989-994 ◽  
Author(s):  
Bin He ◽  
Jianzhong Bei ◽  
Shenguo Wang
2005 ◽  
Vol 40 (20) ◽  
pp. 5499-5506 ◽  
Author(s):  
D. D. Borole ◽  
U. R. Kapadi ◽  
P. P. Mahulikar ◽  
D. G. Hundiwale

2012 ◽  
Vol 529 ◽  
pp. 555-559 ◽  
Author(s):  
Jing Jin ◽  
Jian Peng Xue ◽  
Si Si Cui ◽  
Jie Cao ◽  
Dong Yin Zhang ◽  
...  

In this study, a amphiphilic copolymer, poly ((N-isopropylacrylamide)-co-acrylamide-co- (octadecylacrylate)-co-(Falate-(polyethyleneglycol)-(acrylicacid)))(P(NIPA-co-AAm-co-ODA-co-FPA)) micelles was synthesized by free radical random copolymerization. The obtained amphiphilic copolymers were self-assembled into micelles, which exhibited thermally sensitivity. LCST of the micelles was detected by uv-vis spectrophotometer. The diameter and morphology of micelles were determined by laser particle size analyzer (LPSA) and transmittance electron microscope (TEM), respectively. The micelle with a diameter of 60 nm and LCST of 40 oC was obtained by utilizing of ODA and the feed ratio of NIPA and AAm, respectively, which is satisfied for drug delivery in living body. The maximum DLC was achieved with the amount of ODA (180mg).


Author(s):  
Muhammad Nasir ◽  
Triannisa Rahmawati ◽  
Indriyati ◽  
Fitri Dara ◽  
Desak Gede Sri Andayani

Sign in / Sign up

Export Citation Format

Share Document