Response of young pigs to foot-and-mouth disease oil emulsion vaccination in the presence and absence of maternally derived neutralising antibodies

1986 ◽  
Vol 41 (1) ◽  
pp. 33-39 ◽  
Author(s):  
M.J. FRANCIS ◽  
L. BLACK
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Neutralising Antibodies ◽  
Oil Emulsion ◽  
Young Pigs ◽  
Foot And Mouth ◽  
Presence And Absence

scholarly journals The HSP70-fused foot-and-mouth disease epitope elicits cellular and humoral immunity and drives broad-spectrum protective efficacy

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Hyundong Jo ◽  
Bong Yoon Kim ◽  
So Hui Park ◽  
Hyun Mi Kim ◽  
Sung Ho Shin ◽  
...  
Keyword(s):  
Humoral Immunity ◽  
Broad Spectrum ◽  
Protective Efficacy ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Host Defenses ◽  
Vaccination Site ◽  
Oil Emulsion ◽  
Foot And Mouth ◽  
Cellular And Humoral Immunity

AbstractCurrent foot-and-mouth disease (FMD) vaccines have significant limitations, including side effects due to oil emulsions at the vaccination site, a narrow spectrum of protective efficacy, and incomplete host defenses mediated by humoral immunity alone. To overcome these limitations, new FMD vaccines must ensure improved safety with non-oil-based adjuvants, a broad spectrum of host defenses within/between serotypes, and the simultaneous induction of cellular and humoral immunity. We designed a novel, immune-potent, recombinant protein rpHSP70-AD that induces robust cellular immunity and elicits a broad spectrum of host defenses against FMD virus (FMDV) infections. We demonstrated that an oil emulsion-free vaccine containing rpHSP70-AD mediates early, mid-term, and long-term immunity and drives potent host protection against FMDV type O and A, suggesting its potential as an FMD vaccine adjuvant in mice and pigs. These results suggest a key strategy for establishing next-generation FMD vaccines, including novel adjuvants.

scholarly journals Potential allergens in oil emulsion foot-and-mouth disease vaccines for pigs

1988 ◽  
Vol 101 (2) ◽  
pp. 477-480 ◽  
Author(s):  
L. Black ◽  
M. J Francis
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Oil Emulsion ◽  
Foot And Mouth

Reactions so far reported after the use of oil emulsion (OE) foot-and-mouth disease (FMD) vaccines in pigs have been infrequent and quick to resolve themselves. Although tentatively ascribed to anaphylaxis, these reactions have received little attention and their mechanism of causation has not been established conclusively.

The interference effect of maternally-derived antibodies on the serological performance of pigs immunized with a foot-and-mouth disease oil emulsion vaccine

Vaccine ◽  
2020 ◽  
Vol 38 (7) ◽  
pp. 1723-1729
Author(s):  
Jaejo Kim ◽  
Taeseong Kim ◽  
Jang-Kwan Hong ◽  
Hyang-Sim Lee ◽  
Kwang-Nyeong Lee ◽  
...  
Keyword(s):  
Interference Effect ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Oil Emulsion ◽  
Foot And Mouth

scholarly journals The effect of vaccination regimen on the transfer of foot and mouth disease antibodies from the sow to her piglets

1984 ◽  
Vol 93 (1) ◽  
pp. 123-131 ◽  
Author(s):  
M. J. Francis ◽  
L. Black
Keyword(s):  
Neutralizing Antibodies ◽  
Foot And Mouth Disease ◽  
Neutralizing Antibody ◽  
Mouth Disease ◽  
Oil Emulsion ◽  
Fmd Virus ◽  
Significant Difference ◽  
Foot And Mouth ◽  
Antibody Titres ◽  
Antibody Class

SUMMARYFour groups of pregnant sows were inoculated with type O1 foot and mouth disease (FMD) oil emulsion vaccine at various times before farrowing and samples of the sow's serum, colostrum and milk, and piglet's serum, collected during the first week after farrowing, were analysed for FMD virus neutralizing activity.No FMD neutralizing antibodies were detectable in the piglets serum at birth but they were present 1·5 h after suckling and peak titres were reached 1–3 days later. There was no significant difference between the antibody titres of colostrum samples collected from different teats at farrowing. However, similar samples collected 3 days later showed significant (P < 0·005) fore to hind variation. The principal FMD virus neutralizing antibody class present in the sow's serum at farrowing and in their 3-day-old piglets was governed by the inoculation schedule employed. When the last vaccinations were given ≃ 30 days before farrowing (dbf) the predominant FMD virus neutralizing class was IgG. However, when the sows were vaccinated only ≃ 12 dbf the predominant class was IgM. A significant correlation was observed between the sow's serum titres and colostrum titres at farrowing (r = 0·90), and also between sows colostrum titres at farrowing and their 3-day-old piglets serum titres (r = 0·99).

scholarly journals Antibody response in pig nasal fluid and serum following foot-and-mouth disease infection or vaccination

1983 ◽  
Vol 91 (2) ◽  
pp. 329-334 ◽  
Author(s):  
M. J. Francis ◽  
L. Black
Keyword(s):  
Antibody Response ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Oil Emulsion ◽  
Neutralizing Activity ◽  
Nasal Mucus ◽  
Foot And Mouth ◽  
Virus Exposure ◽  
Response Profiles ◽  
Nasal Fluid

SUMMARYNasal fluid and serum collected from pigs after exposure to live foot and mouth disease (FMD) virus or injection of single oil emulsion (w/o) or double oil emulsion (w/o/w) vaccines were examined for FMD neutralizing activity. After virus exposure the response profiles of serum and nasal mucus were similar to one another. In both, neutralizing activity rose to a peak at one to two weeks after exposure and then subsided slowly. After vaccination with either the w/o or w/o/w preparations a neutralizing response was demonstrable in the serum three to seven days after the first injection, and this was boosted by revaccinations 56 and 117 days later. The neutralizing activity was also detectable in nasal fluid seven days after the first vaccination, but subsequent revaccinations 56 and 117 days later provoked neutralizing titres which were no greater than those observed after the initial vaccination.

scholarly journals Humoral response of pregnant sows to foot and mouth disease vaccination

1986 ◽  
Vol 96 (3) ◽  
pp. 501-511 ◽  
Author(s):  
M. J. Francis ◽  
L. Black
Keyword(s):  
Foot And Mouth Disease ◽  
Humoral Response ◽  
Neutralizing Antibody ◽  
Mouth Disease ◽  
Igg Antibody ◽  
Oil Emulsion ◽  
Foot And Mouth ◽  
Antibody Titres ◽  
Iga Response ◽  
One Year

SUMMARYFour groups of sows were inoculated, either once or twice, with O1BFS 1860 foot and mouth disease oil-emulsion vaccine during pregnancy and samples of serum. for analysis, were collected at intervals for > 300 days.The pregnant sows responded well to vaccination regardless of their state of gestation. Single vaccination produced protective levels of antibody (> 1·53 log10SN50) in 3 out of 4 sows while double vaccination produced protective levels in all 6 sows tested. Anti-FMD IgM antibodies could be detected for 40–60 days after vaccination or revaccination. Anti-FMD IgG antibodies appeared within 10 days of vaccination and persisted, in each sow, for the duration of the study. The anti-FMD IgA response observed was less easy to characterize due to significant animal to animal variation. Although there was no evidence of a fall in the neutralizing antibody titres over one year post vaccination the anti-FMD IgG antibody population did show signs of a change in its heterogenity and avidity.

Early antibody responses of cattle for foot-and-mouth disease quadrivalent double oil emulsion vaccine

2002 ◽  
Vol 87 (2) ◽  
pp. 103-109 ◽  
Author(s):  
P.K. Patil ◽  
J. Bayry ◽  
S.P. Nair ◽  
S. Gopalakrishna ◽  
C.M. Sajjanar ◽  
...  
Keyword(s):  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Antibody Responses ◽  
Oil Emulsion ◽  
Foot And Mouth
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