New Topical Antibiotic For Impetigo Available

2007 ◽  
Vol 38 (6) ◽  
pp. 9
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Topical Antibiotic

scholarly journals Design and characterization of 3D printed, neomycin-eluting poly-L-lactide mats for wound-healing applications

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Mahima Singh ◽  
Sriramakamal Jonnalagadda
Keyword(s):  
Release Kinetics ◽  
Biological Properties ◽  
In Vitro Dissolution ◽  
3D Printer ◽  
Topical Antibiotic ◽  
Young’S Moduli ◽  
Base Polymer ◽  
Potential Applications ◽  
3D Printed

AbstractThis study evaluates the suitability of 3D printed biodegradable mats to load and deliver the topical antibiotic, neomycin, for up to 3 weeks in vitro. A 3D printer equipped with a hot melt extruder was used to print bandage-like wound coverings with porous sizes appropriate for cellular attachment and viability. The semicrystalline polyester, poly-l-lactic acid (PLLA) was used as the base polymer, coated (post-printing) with polyethylene glycols (PEGs) of MWs 400 Da, 6 kDa, or 20 kDa to enable manipulation of physicochemical and biological properties to suit intended applications. The mats were further loaded with a topical antibiotic (neomycin sulfate), and cumulative drug-release monitored for 3 weeks in vitro. Microscopic imaging as well as Scanning Electron Microscopy (SEM) studies showed pore dimensions of 100 × 400 µm. These pore dimensions were achieved without compromising mechanical strength; because of the “tough” individual fibers constituting the mat (Young’s Moduli of 50 ± 20 MPa and Elastic Elongation of 10 ± 5%). The in vitro dissolution study showed first-order release kinetics for neomycin during the first 20 h, followed by diffusion-controlled (Fickian) release for the remaining duration of the study. The release of neomycin suggested that the ability to load neomycin on to PLLA mats increases threefold, as the MW of the applied PEG coating is lowered from 20 kDa to 400 Da. Overall, this study demonstrates a successful approach to using a 3D printer to prepare porous degradable mats for antibiotic delivery with potential applications to dermal regeneration and tissue engineering.

Distribution of topical antibiotic preparations in mastoid cavities

1992 ◽  
Vol 106 (3) ◽  
pp. 247-248 ◽  
Author(s):  
D. P. Martin-Hirsch ◽  
F. Lannigan ◽  
B. Irani
Keyword(s):  
Topical Antibiotic

AbstractTopical antibiotic preparations are widely prescribed in the treatment of infected mastoid cavities with no knowledge of the distribution of the preparation within the cavity. This study ascertains the distribution of drop and spray preparations within mastoid cavities and suggests methods of delivery to maximize coverage.

scholarly journals Post-injection endophthalmitis in eyes receiving vs. not receiving topical antibiotic prophylaxis in Northern Thailand

Eye ◽  
2018 ◽  
Vol 32 (12) ◽  
pp. 1911-1913
Author(s):  
Voraporn Chaikitmongkol ◽  
Onnisa Nanegrungsunk ◽  
Direk Patikulsila ◽  
Janejit Choovuthayakorn ◽  
Nawat Watanachai ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Post Injection ◽  
Topical Antibiotic ◽  
Northern Thailand

scholarly journals Perianal Traumatic Myiasis in a Goat Caused by Wohlfahrtia magnifica (Schiner 1862) (Diptera: Sarcophagidae) in Konya Province of Turkey

2020 ◽  
Vol 1 (3) ◽  
pp. 73-75
Author(s):  
Dilge Sila Davulcu ◽  
Sule Yilmaz ◽  
Onur Ceylan ◽  
Bilal Dik
Keyword(s):  
Potassium Hydroxide ◽  
Morphological Characteristics ◽  
Tissue Loss ◽  
Perianal Area ◽  
Topical Antibiotic ◽  
Deep Tissue ◽  
Case Presentation ◽  
Antiseptic Solution ◽  
Stereo Microscope ◽  
Wohlfahrtia Magnifica

Introduction: The infestation of live humans and animals with dipterous larvae is called Myiasis. These larvae feed on the living or dead tissues, body fluids, and ingested foods of hosts at least for a certain period in myiasis cases. Case Presentation: During clinical examination, several larvae were detected in the perianal area of a goat at Selcuk University, Faculty of Veterinary Medicine, Internal Medicine Clinics. All visible larvae were cleaned by the clinician with the help of forceps. Ivermectin administered against larvae possibly penetrated deep into the wound. A topical antibiotic was also applied, and the wound was washed with an antiseptic solution. Several larvae were preserved in tubes including ethanol (70%) and transferred to parasitology laboratory. Firstly, the larvae were incised with a scalpel and cleared in potassium hydroxide (10%). Then, they were rinsed in distilled water, put into 70% ethanol for dehydration, and stored in 99% ethanol until dissection. The larvae were morphologically examined under a stereo microscope and dissected. The larvae were identified as third instar larvae of Wohlfahrtia magnifica according to the morphological characteristics of cephalo-pharyngeal skeleton, anterior spiracles, and peritremes. Conclusion: It should be kept in mind that in myiasis cases, early diagnosis is a very important factor in preventing deep tissue loss.

scholarly journals Comparative study of Negative Pressure Wound therapy Vs. Local antibiotic cream dressings in acute hand burns second-degree superficial to deep

2021 ◽  
pp. 28-32
Author(s):  
Ganesh Chaudhari ◽  
Satish Sonawane
Keyword(s):  
Comparative Study ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
The Body ◽  
Topical Antibiotic ◽  
Wound Therapy ◽  
Hand Part ◽  
Hand Burns ◽  
Local Antibiotic ◽  
Second Degree

Background: The hand is one of the most common parts of the body involved in burns, i.e., 80%. Even minor burns in the hand may result in severe limitations of function. Early initiation of physiotherapy, topical antibiotic cream treatment, collagen application, splintage, passive exercise for second-degree superficial burns. Materials and methods: A prospective comparative study was conducted in 10 patients with acute hand burns due to thermal burns (scald, flame). All patients with second-degree superficial to intermediate thickness burns were given Negative pressure wound therapy (indigenous NPWT Kit) to one hand and local antibiotic cream to the other hand or other parts of the body to study clinical profile and outcome. Results: A total of 10 patients were studied. The majority of patients were in 19 to 30 years of age group 6 patients (60%), five females, and one male. Pediatric patients account for 4 patients (40%), two female and two male children. Incidence of burns in females 70% and males’ group 30%. Significant reduction in postburn edema in NPWT hand compared to topical antibiotic cream dressing. Healing is fast in NPWT applied hand/part. Conclusion: Negative Pressure Wound Therapy for Acute second-degree superficial burns showed promising results in wound healing and reduced post-burn edema burn in hand in our study.

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