Isoprenoid biosynthesis via the methylerythritol phosphate pathway. (E)-4-Hydroxy-3-methylbut-2-enyl diphosphate: chemical synthesis and formation from methylerythritol cyclodiphosphate by a cell-free system from Escherichia coli

2002 ◽  
Vol 43 (14) ◽  
pp. 2555-2559 ◽  
Author(s):  
Murielle Wolff ◽  
Myriam Seemann ◽  
Catherine Grosdemange-Billiard ◽  
Denis Tritsch ◽  
Narciso Campos ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Chemical Synthesis ◽  
Isoprenoid Biosynthesis ◽  
Free System ◽  
Methylerythritol Phosphate Pathway ◽  
Cell Free System ◽  
Methylerythritol Phosphate ◽  
A Cell

scholarly journals The Effect of Magnesium-Ion Concentration on the Translation of Phage-f2 RNA in a Cell-Free System of Escherichia coli

1972 ◽  
Vol 25 (2) ◽  
pp. 315-322 ◽  
Author(s):  
Wlodzimierz Zagorski ◽  
Witold Filipowicz ◽  
Aleksandra Wodnar ◽  
Andrzej Leonowicz ◽  
Ludwika Zagorska ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Ion Concentration ◽  
Magnesium Ion ◽  
Free System ◽  
Cell Free System ◽  
A Cell

scholarly journals Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase

2005 ◽  
Vol 386 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Lionel KUNTZ ◽  
Denis TRITSCH ◽  
Catherine GROSDEMANGE-BILLIARD ◽  
Andréa HEMMERLIN ◽  
Audrey WILLEM ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Malaria Parasite ◽  
Pathogenic Bacteria ◽  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum ◽  
Petri Dishes ◽  
Antiparasitic Drugs

Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasmodium falciparum. 4-(Hydroxyamino)-4-oxobutylphosphonic acid and 4-[hydroxy(methyl)amino]-4-oxobutyl phosphonic acid, two novel inhibitors of DXR (1-deoxy-D-xylulose 5-phosphate reducto-isomerase), the second enzyme of the pathway, have been synthesized and compared with fosmidomycin, the best known inhibitor of this enzyme. The latter phosphonohydroxamic acid showed a high inhibitory activity towards DXR, much like fosmidomycin, as well as significant antibacterial activity against Escherichia coli in tests on Petri dishes.

Effect of zeolites on protein synthesis in a cell-free system from Escherichia coli

1995 ◽  
Vol 17 (10) ◽  
pp. 1043-1046 ◽  
Author(s):  
Dong-Myung Kim ◽  
You-Eil Kim ◽  
Cha-Yong Choi
Keyword(s):  
Escherichia Coli ◽  
Protein Synthesis ◽  
Free System ◽  
Cell Free System ◽  
A Cell
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