Faculty Opinions recommendation of Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.

2003 ◽  
Author(s):  
Haruo Seto
Keyword(s):  
Escherichia Coli ◽  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate

scholarly journals Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase

2005 ◽  
Vol 386 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Lionel KUNTZ ◽  
Denis TRITSCH ◽  
Catherine GROSDEMANGE-BILLIARD ◽  
Andréa HEMMERLIN ◽  
Audrey WILLEM ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Malaria Parasite ◽  
Pathogenic Bacteria ◽  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum ◽  
Petri Dishes ◽  
Antiparasitic Drugs

Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasmodium falciparum. 4-(Hydroxyamino)-4-oxobutylphosphonic acid and 4-[hydroxy(methyl)amino]-4-oxobutyl phosphonic acid, two novel inhibitors of DXR (1-deoxy-D-xylulose 5-phosphate reducto-isomerase), the second enzyme of the pathway, have been synthesized and compared with fosmidomycin, the best known inhibitor of this enzyme. The latter phosphonohydroxamic acid showed a high inhibitory activity towards DXR, much like fosmidomycin, as well as significant antibacterial activity against Escherichia coli in tests on Petri dishes.

Isoprenoid biosynthesis via the methylerythritol phosphate pathway: accumulation of 2- C -methyl- d -erythritol 2,4-cyclodiphosphate in a gcpE deficient mutant of Escherichia coli

2002 ◽  
Vol 43 (5) ◽  
pp. 775-778 ◽  
Author(s):  
Myriam Seemann ◽  
Narciso Campos ◽  
Manuel Rodrı́guez-Concepción ◽  
Jean-François Hoeffler ◽  
Catherine Grosdemange-Billiard ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Isoprenoid Biosynthesis ◽  
Deficient Mutant ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate

Identification of lethal mutations in Escherichia coli genes encoding enzymes of the methylerythritol phosphate pathway

2003 ◽  
Vol 307 (2) ◽  
pp. 408-415 ◽  
Author(s):  
Susanna Sauret-Güeto ◽  
Ana Ramos-Valdivia ◽  
Ester Ibáñez ◽  
Albert Boronat ◽  
Manuel Rodrı́guez-Concepción
Keyword(s):  
Escherichia Coli ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate ◽  
Lethal Mutations ◽  
Genes Encoding

scholarly journals Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis

2013 ◽  
Vol 82 (1) ◽  
pp. 497-530 ◽  
Author(s):  
Lishan Zhao ◽  
Wei-chen Chang ◽  
Youli Xiao ◽  
Hung-wen Liu ◽  
Pinghua Liu
Keyword(s):  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate
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