Peripheral opioid receptors, nitric oxide and cgmp mediate antinociception induced by Crotalus durissus terrificus venom

Toxicon ◽  
2000 ◽  
Vol 38 (4) ◽  
pp. 588-589
Keyword(s):  
Nitric Oxide ◽  
Opioid Receptors ◽  
Crotalus Durissus Terrificus ◽  
Peripheral Opioid Receptors ◽  
Crotalus Durissus

Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice

2007 ◽  
Vol 53 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Luis Menéndez ◽  
Lucía Juárez ◽  
Verónica García ◽  
Agustín Hidalgo ◽  
Ana Baamonde
Keyword(s):  
Nitric Oxide ◽  
Opioid Receptors ◽  
Bone Cancer ◽  
Peripheral Opioid Receptors

scholarly journals The endogenous opioid system modulates defensive behavior evoked by Crotalus durissus terrificus: Panicolytic-like effect of intracollicular non-selective opioid receptors blockade

2018 ◽  
Vol 33 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Fabrício Calvo ◽  
Bruno Lobão-Soares ◽  
Renato Leonardo de Freitas ◽  
Tatiana Paschoalin-Maurin ◽  
Tayllon dos Anjos-Garcia ◽  
...  
Keyword(s):  
Inferior Colliculus ◽  
Opioid Receptors ◽  
Panic Attack ◽  
Opioid Peptide ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Endogenous Opioid Peptide ◽  
Crotalus Durissus Terrificus ◽  
Flat Back ◽  
Crotalus Durissus

Background: There is a controversy regarding the key role played by opioid peptide neurotransmission in the modulation of panic-attack-related responses. Aims: Using a prey versus rattlesnakes paradigm, the present work investigated the involvement of the endogenous opioid peptide-mediated system of the inferior colliculus in the modulation of panic attack-related responses. Methods: Wistar rats were pretreated with intracollicular administration of either physiological saline or naloxone at different concentrations and confronted with rattlesnakes ( Crotalus durissus terrificus). The prey versus rattlesnake confrontations were performed in a polygonal arena for snakes. The defensive behaviors displayed by prey (defensive attention, defensive immobility, escape response, flat back approach and startle) were recorded twice: firstly, over a period of 15 min the presence of the predator and a re-exposure was performed 24 h after the confrontation, when animals were exposed to the experimental enclosure without the rattlesnake. Results: The intramesencephalic non-specific blockade of opioid receptors with microinjections of naloxone at higher doses decreased both anxiety- (defensive attention and flat back approach) and panic attack-like (defensive immobility and escape) behaviors, evoked in the presence of rattlesnakes and increased non-defensive responses. During the exposure to the experimental context, there was a decrease in duration of defensive attention. Conclusions: These findings suggest a panicolytic-like effect of endogenous opioid receptors antagonism in the inferior colliculus on innate (panic attack) and conditioned (anticipatory anxiety) fear in rats threatened by rattlesnakes.

L-aminoacid oxidase from Crotalus durissus terrificus snake venom and its antibacterial potential

Toxicon ◽  
2019 ◽  
Vol 168 ◽  
pp. S13
Author(s):  
Leonardo Melo ◽  
Lidiane Nunes Barbosa ◽  
Rui Seabra Ferreira Junior ◽  
Benedito Barraviera ◽  
Luciana Curtolo De Barros ◽  
...  
Keyword(s):  
Snake Venom ◽  
Crotalus Durissus Terrificus ◽  
Crotalus Durissus ◽  
Antibacterial Potential

scholarly journals Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0187857 ◽  
Author(s):  
Jacqueline Farinha Shimizu ◽  
Carina Machado Pereira ◽  
Cintia Bittar ◽  
Mariana Nogueira Batista ◽  
Guilherme Rodrigues Fernandes Campos ◽  
...  
Keyword(s):  
Life Cycle ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Crotalus Durissus Terrificus ◽  
Virus Life Cycle ◽  
Crotalus Durissus

Semen collection and evaluation in free-ranging Brazilian rattlesnakes (Crotalus durissus terrificus)

Zoo Biology ◽  
2007 ◽  
Vol 26 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Rogério Loesch Zacariotti ◽  
Kathleen Fernandes Grego ◽  
Wilson Fernandes ◽  
Sávio Stefanini Sant'Anna ◽  
Marcelo Alcindo de Barros Vaz Guimarães
Keyword(s):  
Crotalus Durissus Terrificus ◽  
Semen Collection ◽  
Crotalus Durissus ◽  
Free Ranging

scholarly journals Inhibition of Neurotoxic Secretory Phospholipases A2Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated fromHarpalyce brasilianaBenth

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Rafael M. Ximenes ◽  
Marcelo M. Rabello ◽  
Renata M. Araújo ◽  
Edilberto R. Silveira ◽  
Fábio H. R. Fagundes ◽  
...  
Keyword(s):  
Active Site ◽  
Initial Step ◽  
Significant Inhibition ◽  
Lipid Mediators ◽  
Naja Naja ◽  
Crotalus Durissus Terrificus ◽  
Docking Calculations ◽  
Crotalus Durissus ◽  
Bothrops Pirajai ◽  
Phospholipases A

Secretory phospholipases A2(sPLA2) exert proinflammatory actions through lipid mediators. These enzymes have been found to be elevated in many inflammatory disorders such as rheumatoid arthritis, sepsis, and atherosclerosis. The aim of this study was to evaluate the effect of harpalycin 2 (Har2), an isoflavone isolated fromHarpalyce brasilianaBenth., in the enzymatic, edematogenic, and myotoxic activities of sPLA2fromBothrops pirajai, Crotalus durissus terrificus, Apis mellifera,andNaja najavenoms. Har2 inhibits all sPLA2tested. PrTX-III (B. pirajaivenom) was inhibited at about 58.7%, Cdt F15 (C. d. terrificusvenom) at 78.8%, Apis (from bee venom) at 87.7%, and Naja (N. najavenom) at 88.1%. Edema induced by exogenous sPLA2administration performed in mice paws showed significant inhibition by Har2 at the initial step. In addition, Har2 also inhibited the myotoxic activity of these sPLA2s. In order to understand how Har2 interacts with these enzymes, docking calculations were made, indicating that the residues His48 and Asp49 in the active site of these enzymes interacted powerfully with Har2 through hydrogen bonds. These data pointed to a possible anti-inflammatory activity of Har2 through sPLA2inhibition.

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