Study of the relationship between nonmuscle myosin heavy chain B (SMemb) and acute rejection of rat renal transplantation models

2000 ◽  
Vol 32 (7) ◽  
pp. 1997-1998
Author(s):  
Y Watanabe ◽  
R Yoshimura ◽  
S Wada ◽  
J Chargui ◽  
J Suzuki ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Nonmuscle Myosin ◽  
The Relationship ◽  
Rat Renal Transplantation

The expression of nonmuscle myosin heavy chain in rat renal transplantation

1999 ◽  
Vol 31 (7) ◽  
pp. 2709-2710
Author(s):  
Y Watanabe ◽  
R Yoshimura ◽  
J Suzuki ◽  
T Hase ◽  
S Wada ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Nonmuscle Myosin ◽  
Rat Renal Transplantation

Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection

2008 ◽  
Vol 456 (6) ◽  
pp. 1075-1084 ◽  
Author(s):  
Stefan Reuter ◽  
Ana Velic ◽  
Bayram Edemir ◽  
Rita Schröter ◽  
Hermann Pavenstädt ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Protective Role ◽  
Rat Renal Transplantation

The relationship between slow and fast myosin heavy chain content, calpastatin and meat tenderness in different ovine skeletal muscles

Meat Science ◽  
2005 ◽  
Vol 69 (1) ◽  
pp. 17-25 ◽  
Author(s):  
A.Q. Sazili ◽  
T. Parr ◽  
P.L. Sensky ◽  
S.W. Jones ◽  
R.G. Bardsley ◽  
...  
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Skeletal Muscles ◽  
Meat Tenderness ◽  
Fast Myosin ◽  
Fast Myosin Heavy Chain ◽  
The Relationship

B2 exon splicing of nonmuscle myosin heavy chain IIB is differently regulated in developing and adult rat brain

2000 ◽  
Vol 37 (4) ◽  
pp. 299-306 ◽  
Author(s):  
Taisuke Miyazaki ◽  
Masahiko Watanabe ◽  
Akihiko Yamagishi ◽  
Masayuki Takahashi
Keyword(s):  
Myosin Heavy Chain ◽  
Rat Brain ◽  
Heavy Chain ◽  
Nonmuscle Myosin ◽  
Adult Rat ◽  
Exon Splicing ◽  
Adult Rat Brain

In Situ Interleukin-6 Transcription in Embryonic Nonmuscle Myosin Heavy Chain Expressing Immature Mesenchyme Cells of Cardiac Myxoma

2000 ◽  
Vol 9 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Jun-ichi Suzuki ◽  
Kei Takayama ◽  
Fujio Mitsui ◽  
Tetsuya Kono ◽  
Yoshikazu Yazaki ◽  
...  
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Interleukin 6 ◽  
Cardiac Myxoma ◽  
Nonmuscle Myosin ◽  
Mesenchyme Cells

scholarly journals Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin

Blood ◽  
2010 ◽  
Vol 115 (19) ◽  
pp. 3907-3915 ◽  
Author(s):  
Charles C. Chu ◽  
Rosa Catera ◽  
Lu Zhang ◽  
Sebastien Didier ◽  
Briana M. Agagnina ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Lymphocytic Leukemia ◽  
Apoptotic Cells ◽  
Nonmuscle Myosin ◽  
Cell Of Origin ◽  
Poor Clinical Outcome ◽  
Mutation Status ◽  
Poor Patient Survival

Abstract Many B-cell chronic lymphocytic leukemia (CLL) monoclonal antibodies (mAbs) can be grouped into subsets based on nearly identical stereotyped sequences. Subset 6 CLL mAbs recognize nonmuscle myosin heavy chain IIA (MYHIIA). Herein, we report that during apoptosis, MYHIIA becomes exposed on the cell surface of a subgroup of apoptotic cells, allowing subset 6 CLL mAbs to bind with it. Because other non–subset 6 CLL mAbs interact with apoptotic cells, 26 CLL mAbs, including 24 not belonging to subset 6, were tested for reactivity with MYHIIA-exposed apoptotic cells (MEACs). More than 60% of CLL mAbs bound MEACs well; most of these mAbs expressed unmutated IGHV (15 of 16) and belonged to a stereotyped subset (14 of 16). Binding to MEACs inversely correlated with the degree of IGHV mutation. Interestingly, high binding to MEACs significantly correlated with poor patient survival, suggesting that the basis of IGHV mutation status as a CLL prognostic factor reflects antigen binding. Finally, natural antibodies from human serum also reacted with MEACs. Taken together, our data indicate that a large proportion of CLL clones emerge from natural antibody-producing cells expressing immunoglobulins that recognize MEACs, and that this reactivity is associated with poor clinical outcome.

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