Anticoagulant effect and action mechanism of sulphated flavonoids from Flaveria bidentis

SummaryThe minimal concentration of the platelet aggregation principle (Platelet Aggregoserpen- tin, PAS) necessary to induce platelet aggregation was 10 ng/ml, about one-hundredth of that of the crude venom. PAS induced the release of platelet factors 3 and 4 from platelets, but the released platelet factor 3 was easily inactivated by the anti-phospholipid effect of PAS. Pretreatment of platelets with neuraminidase potentiated PAS-induced platelet aggregation. PAS-induced platelet aggregation was independent on released ADP; it could occur in the ADP-removing systems, such as apyrase or a combination of phosphoenolpyruvate and pyruvate kinase. However, PAS-induced platelet aggregation could be inhibited by adenine nucleotides and adenosine.PAS-induced platelet aggregation was inhibited by some anti-inflammatory agents, antimalarial drugs, local anesthetics, antihistamine and smooth muscle relaxants. After deaggregation of PAS-treated platelets, thrombin and sodium arachidonate could further induce platelet aggregation, but ADP and second dose of PAS could not. It is concluded that PAS-induced platelet aggregation is due to prostaglandin synthesis. Recent literatures on the mechanism of platelet aggregation were surveyed and the actions of PAS were discussed.

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“In vitro” Neutralization with Oxalate Ion of the Anticoagulant Effect of Heparin

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654928 ◽

1961 ◽

Vol 05 (02) ◽

pp. 314-318 ◽

Cited By ~ 1

Author(s):

W. O Cruz ◽

L Meis ◽

C. P Dietrich

Keyword(s):

Calcium Oxalate ◽

Aluminium Hydroxide ◽

Barium Sulfate ◽

Anticoagulant Effect ◽

Normal Plasma ◽

Oxalate Ion

SummaryHeparinized blood or plasma coagulates if, after addition of oxalate, recalcification follows. Of the decalcifying agents only oxalate ion has been suitable for demonstrating this phenomenon. Oxalate seem to accomplish two different roles connected with this effect: a fundamental one, i. e., to sensitize a heparinlipoprotein complex to the action of an anti-heparin factor found in normal plasma or serum and a secondary one, related to its capacity to adsorb this antiheparin factor. The latter is removable by centrifugation. This anti-heparin oxalate factor, which is able to counteract the action of heparin after previous addition of oxalate, was found in sequestrened, Dowex 50 resin plasma or in serum, but is not active in citrated plasma. This factor was removed from plasma by adsorption with barium sulfate, aluminium hydroxide or calcium oxalate and was eluted from these adsorbants after incubation with saline.

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Faculty Opinions recommendation of Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725571445.793536699 ◽

2017 ◽

Author(s):

Ian Beales

Keyword(s):

Phase 1 ◽

Anticoagulant Effect ◽

Healthy Male ◽

Double Blind ◽

Phase 1 Trial ◽

Healthy Male Volunteers ◽

Male Volunteers

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Faculty Opinions recommendation of Efficient 2-phosphoglycolate degradation is required to maintain carbon assimilation and allocation in the C4 plant Flaveria bidentis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734291448.793552324 ◽

2018 ◽

Author(s):

George Ratcliffe

Keyword(s):

Carbon Assimilation ◽

C4 Plant ◽

Flaveria Bidentis

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Study on Country and Township Cadre’s Action Mechanism as Strategic Group in China

The Journal of Modern China Studies ◽

10.35820/jmcs.19.4.4 ◽

2018 ◽

Vol 19 (4) ◽

pp. 111-155

Author(s):

Kwisik Min

Keyword(s):

Action Mechanism ◽

Strategic Group

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Conventional Versus Natural Alternative Treatments for Leishmaniasis: A Review

Current Topics in Medicinal Chemistry ◽

10.2174/1568026618666181002114448 ◽

2018 ◽

Vol 18 (15) ◽

pp. 1275-1286 ◽

Cited By ~ 12

Author(s):

Luiz Felipe Domingues Passero ◽

Lucas Antal Cruz ◽

Gabriela Santos-Gomes ◽

Eliana Rodrigues ◽

Márcia Dalastra Laurenti ◽

...

Keyword(s):

Side Effects ◽

Visceral Leishmaniasis ◽

Traditional Knowledge ◽

Conventional Therapy ◽

Pathogenic Species ◽

Action Mechanism ◽

In Vivo Assays ◽

Clinical Forms

Leishmaniasis is a neglected disease caused by protozoan belonging to the Leishmania genus. There are at least 16 pathogenic species for humans that are able to cause different clinical forms, such as cutaneous or visceral leishmaniasis. In spite of the different species and clinical forms, the treatment is performed with few drug options that, in most cases, are considered outdated. In addition, patients under classical treatment show serious side effects during drug administration, moreover parasites are able to become resistant to medicines. Thus, it is believed and well accepted that is urgent and necessary to develop new therapeutic options to overpass these concerns about conventional therapy of leishmaniasis. The present review will focus on the efficacy, side effects and action mechanism of classic drugs used in the treatment of leishmaniasis, as well as the importance of traditional knowledge for directing a rational search toward the discovery and characterization of new and effective molecules (in vivo assays) from plants to be used against leishmaniasis.

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