Diagnostic Value of Plasma Thrombin-Antithrombin III Complex and D-Dimer Concentration in Patients with Varicose Veins for Exclusion of Deep-Vein Thrombosis

SummaryThis study was performed to determine the accuracy of D-Dimer fibrin derivatives, thrombin-antithrombin III (TAT) complexes and prothrombin fragments 1 + 2 (F 1 + 2) determinations for the diagnosis of deep vein thrombosis (DVT). One hundred and sixteen consecutive patients referred to the angiology unit of our hospital for a clinically suspected DVT were investigated. They were submitted to mercury strain gauge plethysmography and to ultrasonic duplex scanning examination; in cases of inconclusive results or of proximal DVT (n = 35), an ascending phlebography was performed. After these investigations were completed, the diagnosis of DVT was confirmed in 34 and excluded in 82. One half of the patients were already under anticoagulant therapy at the time of investigation. The 3 biological markers were assayed using commercially available ELISA techniques and the D-Dimer was also assayed with a fast latex method. The normal distribution of these markers was established in 40 healthy blood donors. The most accurate assay for the diagnosis of DVT was the D-Dimer ELISA which had both a high sensitivity (94%) and a high negative predictive value (95%). The D-Dirner latex, TAT complexes and F 1 + 2 were far less sensitive and provided negative predictive values which ranged between 78 and 85%. In spite of positive and significant correlations between the levels of ihe 3 markers, their association did not improve their overall accuracy for detecting D\/L Therefore, with the exception of the D-Dimer ELISA, these markers were of little value for the diagnosis of DVT in this specific population.

Download Full-text

Diagnostic Value of Neutrophil Lymphocyte Ratio and D-Dimer as Biological Markers of Deep Vein Thrombosis in Patients Presenting with Unilateral Limb Edema

Journal of Blood Medicine ◽

10.2147/jbm.s291226 ◽

2021 ◽

Vol Volume 12 ◽

pp. 313-325

Author(s):

Ikhwan Rinaldi ◽

Rachmat Hamonangan ◽

Mohamad Syahrir Azizi ◽

Rahmat Cahyanur ◽

Fadila Wirawan ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Biological Markers ◽

Diagnostic Value ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Vein Thrombosis ◽

Limb Edema ◽

Deep Vein ◽

D Dimer

Download Full-text

Risk Factors for Deep Vein Thrombosis after Orthopedic Surgery and the Diagnostic Value of D-Dimer

Annals of Vascular Surgery ◽

10.1016/j.avsg.2014.12.022 ◽

2015 ◽

Vol 29 (4) ◽

pp. 675-681 ◽

Cited By ~ 14

Author(s):

Yong Jiang ◽

Jie Li ◽

Yang Liu ◽

Yuan-Cheng Li ◽

Wei-Guo Zhang

Keyword(s):

Risk Factors ◽

Deep Vein Thrombosis ◽

Orthopedic Surgery ◽

Diagnostic Value ◽

Vein Thrombosis ◽

Deep Vein ◽

D Dimer

Download Full-text

Levels of thrombin - antithrombin-III complex and factor VIII activity in relation to post-operative deep vein thrombosis and influence of prophylaxis with a low-molecular-weight heparin

Blood Coagulation & Fibrinolysis ◽

10.1097/00001721-199010000-00006 ◽

1990 ◽

Vol 1 (5) ◽

pp. 389-392 ◽

Cited By ~ 5

Author(s):

J. V. S??oSrensen ◽

L. C. Borris ◽

M. R. Lassen ◽

H. M. Christiansen ◽

P. SchoStt ◽

...

Keyword(s):

Molecular Weight ◽

Deep Vein Thrombosis ◽

Factor Viii ◽

Low Molecular Weight Heparin ◽

Antithrombin Iii ◽

Low Molecular Weight ◽

Factor Viii Activity ◽

Vein Thrombosis ◽

Deep Vein ◽

Thrombin Antithrombin Iii Complex

Download Full-text

Diagnostic Value of the D-Dimer Test in Deep Vein Thrombosis: Improved Results by a New Assay Method and by Using Discriminate Levels

Thrombosis Research ◽

10.1016/s0049-3848(01)00221-3 ◽

2001 ◽

Vol 102 (2) ◽

pp. 125-131 ◽

Cited By ~ 15

Author(s):

David Shitrit ◽

Judith Heyd ◽

David Raveh ◽

Bernard Rudensky

Keyword(s):

Deep Vein Thrombosis ◽

Diagnostic Value ◽

Assay Method ◽

Vein Thrombosis ◽

Deep Vein ◽

D Dimer

Download Full-text

Limited diagnostic value of Wells-score and D-dimer testing in hospitalized dermatologic patients with symptoms of deep vein thrombosis

European Journal of Dermatology ◽

10.1684/ejd.2013.2188 ◽

2013 ◽

Vol 23 (6) ◽

pp. 830-836 ◽

Cited By ~ 1

Author(s):

Holger A. Haenssle ◽

Nadia Ayad ◽

Timo Buhl ◽

Albert Rosenberger ◽

Kai Martin Thoms ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Diagnostic Value ◽

Vein Thrombosis ◽

Wells Score ◽

Deep Vein ◽

D Dimer

Download Full-text

Influence of Long Term Oral Anticoagulants upon Prothrombin Fragment 1 + 2, Thrombin-Antithrombin III Complex and D-Dimer Levels in Patients Affected by Proximal Deep Vein Thrombosis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651601 ◽

1993 ◽

Vol 69 (04) ◽

pp. 302-305 ◽

Cited By ~ 28

Author(s):

A Elias ◽

S Bonfils ◽

M Daoud-Elias ◽

B Gauthier ◽

P Sié ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Antithrombin Iii ◽

Oral Anticoagulants ◽

Proximal Deep Vein Thrombosis ◽

Normal Range ◽

Prothrombin Fragment ◽

Vein Thrombosis ◽

Deep Vein ◽

D Dimer

SummaryWe have investigated the influence of long term oral anticoagulants (OAC) upon the plasma levels of prothrombin fragment 1 + 2 (F1 + 2), of thrombin-antithrombin III complexes (TAT) and of D-Dimer in 20 patients affected by a proximal deep vein thrombosis (DVT) diagnosed by ultrasonic duplex scanning. Patients (63 ± 17 years, mean ± SD) were sampled at the beginning of the OAC treatment (day 1), which was started 1 to 6 days after diagnosis confirmation and full heparinization, and then 8, 35 and 92 days after. The results were compared to those obtained in a blood donor population (39 ± 10 years) and to an age-matched healthy population (63 ± 19 years). The mean INR determined on days 8, 35 and 92 were almost identical (2.8 ± 0.7, 2.9 ± 0.9 and 2.8 ± 0.6 respectively). In contrast, highly significant variations of the three markers were recorded during the observation period. Eight days after the beginning of OAC, increased levels of TAT complexes were associated with subnormal levels of F1 + 2 suggesting persistence of a hypercoagulable state. On the further sampling times, TAT complexes were in the normal range while F1 + 2 were far below the normal range. Between day 1 and day 92, the levels of D-Dimer continuously decreased reflecting a long-term fibrinolytic process.This study clearly indicates that high INR are not systematically associated with very low F1 + 2 levels, particularly in the acute phase of thrombosis. Whether or not it is possible to reduce the intensity of the anticoagulant treatment 1 month after its initiation on the basis of very low levels of F1 + 2 can only be determined by prospective clinical trials.

Download Full-text

The value of D-dimer, ESR and CRP in the Diagnosis of Deep Vein Thrombosis of Lower Limbs After Hip and Knee Joint Replacement

10.21203/rs.3.rs-171633/v1 ◽

2021 ◽

Author(s):

Xinchao Fan ◽

Kai Zhang ◽

Xilong Sun ◽

Xiangrui Duan ◽

Dadi Wan ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Lower Extremity ◽

Prothrombin Time ◽

Knee Replacement ◽

Area Under The Curve ◽

Diagnostic Value ◽

Lower Limbs ◽

Vein Thrombosis ◽

Deep Vein ◽

D Dimer

Abstract Objective: To investigate the diagnostic value of D-dimer, ESR and CRP in deep vein thrombosis (DVT) of lower extremity after hip and knee replacement.Methods: Clinical data of 216 patients who underwent hip and knee replacement in our hospital from January 2018 to November 2020 were retrospectively analyzed. Among them, there were 86 patients with lower extremity deep vein thrombosis and 130 patients without lower extremity deep vein thrombosis. Preoperative blood D-dimer, prothrombin time, fibrinogen content, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), albumin and hemoglobin levels were collected. Chi-square test was used to compare the rate of deep vein thrombosis in lower limbs. The PSM propensity score matching method was used to select 86 patients from 130 patients without lower extremity deep vein thrombosis (DVT) as control group. The levels of D-dimer, albumin and hemoglobin in 172 patients were compared, and the diagnostic efficacy of D-dimer, ESR and CRP in the diagnosis of lower extremity deep vein thrombosis after hip and knee replacement was analyzed by ROC curve.Results: ROC curve analysis results showed that: The optimal cut-off values of D-dimer, prothrombin time, ESR, CRP and age for the diagnosis of DVT of lower extremity after hip replacement were 1.745mg/L, 10.850s, 15.500mm/h, 2.375mg/L and 72 years old, respectively. The sensitivity was 71.8%, 66.7%, 61.5%, 94.9%, 71.8%, the specificity was 74.1%, 66.7%, 70.4%, 33.3%, 100%, and the area under the curve was 0.746, 0.683, 0.658, 0.651, 0.869. The optimal truncation value of D-dimer for the diagnosis of DVT of lower extremity after knee replacement was 0.285mg/L, the sensitivity was 78.7%, the specificity was 44.1%, and the area under the curve was 0.622.Conclusion: The diagnostic value of D-dimer in the formation of lower extremity DVT after knee arthroplasty is higher than that after hip arthroplasty, but the diagnostic value of prothrombin time, ESR, CRP and age in the formation of lower extremity DVT after hip arthroplasty is higher than that after knee arthroplasty.

Download Full-text