[40] Analysis of zeaxanthin distribution within individual human retinas

Author(s):  
John T. Landrum ◽  
Richard A. Bone ◽  
Linda L. Moore ◽  
Christina M. Gomez
Keyword(s):  
Author(s):  
Scott Marek ◽  
Joshua S. Siegel ◽  
Evan M. Gordon ◽  
Ryan V. Raut ◽  
Caterina Gratton ◽  
...  

Author(s):  
Elaine Auyoung

This chapter demonstrates how the organization of narrative information can shape a reader’s impression of what is represented. It focuses on two ways in which concrete objects are arranged in Charles Dickens’s Bleak House: as specific members of general categories and as part of causally connected narrative structures. Dickens relies on these representational strategies to capture a scale of reality no longer suited to the individual human body. In doing so, he also reveals that the realist novel’s conventional commitment to individual experience at the scale of concrete particulars reflects constraints on the comprehension process.


Author(s):  
Nick Friedman

Abstract In this article, I critically review the economic theory of corporate liability design, focusing on the allocation of liability between a corporation and its individual human agents. I apply this theory to transnational commercial contexts where human rights abuses occur and assess the likely efficacy of some putative liability regimes, including regimes requiring corporations to undertake human rights due diligence throughout their global supply chains. I advance a set of general considerations justifying the efficacy of due diligence in relation to alternative liability regimes. I argue, however, that due diligence regimes will likely under-deter severe human rights abuses unless they are supported by substantial entity-level sanctions and, in at least some cases, by supplementary liability for individual executives. The analysis has significant policy implications for current national and international efforts to enforce human rights norms against corporations.


1977 ◽  
Vol 252 (1) ◽  
pp. 173-180 ◽  
Author(s):  
T W Borun ◽  
K Ajiro ◽  
A Zweidler ◽  
T W Dolby ◽  
R E Stephens

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dominika Dziedzicka ◽  
Mukul Tewary ◽  
Alexander Keller ◽  
Laurentijn Tilleman ◽  
Laura Prochazka ◽  
...  

AbstractLow differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell cultures, as well as transcriptomic profiling, to investigate how variability in signalling pathway activity between human embryonic stem cell lines affects their differentiation efficiency towards definitive endoderm (DE). We show that endogenous suppression of WNT signalling in hPSCs at the onset of differentiation prevents the switch from self-renewal to DE specification. Gene expression profiling reveals that this inefficient switch is reflected in NANOG expression dynamics. Importantly, we demonstrate that higher WNT stimulation or inhibition of the PI3K/AKT signalling can overcome the DE commitment blockage. Our findings highlight that redirection of the activity of Activin/NODAL pathway by WNT signalling towards mediating DE fate specification is a vulnerable spot, as disruption of this process can result in poor hPSC specification towards DE.


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