Chapter 12 Serine Kinases of Insulin Receptor Substrate Proteins

2009 ◽  
pp. 313-349 ◽  
Author(s):  
Sigalit Boura‐Halfon ◽  
Yehiel Zick
Keyword(s):  
Insulin Receptor ◽  
Insulin Receptor Substrate ◽  
Serine Kinases ◽  
Substrate Proteins

scholarly journals Expression and function of the insulin receptor substrate proteins in cancer

2009 ◽  
Vol 7 (1) ◽  
pp. 14 ◽  
Author(s):  
Katerina Mardilovich ◽  
Shannon L Pankratz ◽  
Leslie M Shaw
Keyword(s):  
Insulin Receptor ◽  
Insulin Receptor Substrate ◽  
And Function ◽  
Substrate Proteins

scholarly journals Serine Phosphorylation of Insulin Receptor Substrate-1: A Novel Target for the Reversal of Insulin Resistance

2001 ◽  
Vol 15 (11) ◽  
pp. 1864-1869 ◽  
Author(s):  
Gerasimos P. Sykiotis ◽  
Athanasios G. Papavassiliou
Keyword(s):  
Insulin Resistance ◽  
Insulin Receptor ◽  
Sedentary Lifestyle ◽  
Serine Phosphorylation ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1 ◽  
Selective Targeting ◽  
Individualized Approach ◽  
Serine Kinases ◽  
Novel Target

Abstract Insulin resistance, the failure to respond to normal circulating concentrations of insulin, is a common state associated with obesity, aging, and a sedentary lifestyle. Compelling evidence implicates TNFα as the cause and link between obesity and insulin resistance. Serine phosphorylation of insulin receptor substrate-1 seems prominent among the mechanisms of TNFα-induced insulin resistance. Recent advances indicate that serine kinases may phosphorylate and thus inhibit the tyrosine phosphorylation of insulin receptor substrate-1, revealing an integration point of TNFα and insulin signaling pathways. Selective targeting of the molecular scenery whereby this key phosphorylation occurs/operates represents a rich area for the development of rationally designed new antidiabetic drugs. In relation to efficacy and side effects, this prospect should permit a more precise and perhaps individualized approach to therapeutic intervention, allowing clinicians to focus the attack where the problem lies.

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