The Relationship Between Cigarette Smoking and Quality of Life After Lung Cancer Diagnosis

Purpose Evidence has suggested a clinically meaningful relationship between self-reported quality of life (QOL) of a patient with cancer at the time of receiving a cancer diagnosis and overall survival (OS). This study evaluated the prognostic value of QOL assessments with regard to OS in a large cohort of patients with lung cancer. Patients and Methods A total of 2,442 patients with non–small-cell lung cancer were observed between 1997 and 2007 and completed a single-item measure of overall QOL within the first 6 months of receiving a lung cancer diagnosis; these were dichotomized using an a priori definition of a clinically deficient score (CDS; ≤ 50 v > 50). Kaplan-Meier estimates and Cox models were used to evaluate the prognostic importance of QOL on OS alone and in the presence of covariates. Logistic regression modeling was used to identify which clinical and patient characteristics were related to a clinically meaningful deficit in QOL. Results QOL deficits at time of lung cancer diagnosis were significantly associated with OS (hazard ratio [HR], 1.55; P < .001), as were performance status, older age, smoking history, male sex, treatment factors, and stage of disease. The median survival for patients with CDS QOL was 1.6 years versus 5.6 years for patients with non-CDS QOL. After controlling for all these covariates, the indication of a clinically deficient baseline QOL still contributed significantly to the prediction of patient survival (HR, 0.67; P < .001). Conclusion Overall QOL measured by a simple single item at the time of lung cancer diagnosis is a significant and independent prognostic factor for survival in patients with lung cancer.

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A mixed methods study of lung cancer diagnosis affecting quality of life

RECIIS ◽

10.3395/reciis.v2i1.128en ◽

2008 ◽

Vol 2 (1) ◽

Author(s):

Carina Berterö

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Mixed Methods ◽

Cancer Diagnosis ◽

Mixed Methods Study ◽

Lung Cancer Diagnosis

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Autofluorescence bronchoscopy and lung cancer diagnosis

Pneumologia ◽

10.2478/pneum-2021-0002 ◽

2021 ◽

Vol 69 (3) ◽

pp. 135-141

Author(s):

Camelia Bădescu ◽

Florin Mihălṭan

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Early Diagnosis ◽

Cancer Diagnosis ◽

Screening Method ◽

New Method ◽

Lung Cancer Diagnosis ◽

Autofluorescence Bronchoscopy ◽

Mucosal Lesions

Abstract Lung cancer (LC), is a disease who has increasing prevalence, with a major impact to morbidity and mortality but also significant consumption of resources. The incidence of LC cases is in progression and early diagnosis becomes extremely important in increasing the quality of life and survival. Detection of preneoplastic mucosal lesions can be performed with autofluorescence bronchoscopy (AF). This is not a new method of diagnosis being still in research for standardization and an applicability as easy as possible. AF should be used as a screening method in pacients with suspected LC.

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OA03.06 Impact of an EGFR-Lung Cancer Diagnosis on Quality of Life of Patients: Learnings from Project Priority

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2019.09.036 ◽

2019 ◽

Vol 14 (11) ◽

pp. S1132-S1133

Author(s):

U. Basu Roy ◽

I. Elkins ◽

J. Feldman ◽

A. Figueras ◽

T. Kennedy

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Cancer Diagnosis ◽

Lung Cancer Diagnosis

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Venous and Lung Thromboembolism in the Context of Lung Cancer: Clinical Manifestations, Risk Factors and Prognosis

Acta Médica Portuguesa ◽

10.20344/amp.10260 ◽

2019 ◽

Vol 32 (10) ◽

pp. 647 ◽

Cited By ~ 1

Author(s):

Rosana Maia ◽

Inês Neves ◽

António Morais ◽

Henrique Queiroga

Keyword(s):

Lung Cancer ◽

Venous Thromboembolism ◽

Cancer Diagnosis ◽

Negative Impact ◽

Clinical Manifestations ◽

Research Subjects ◽

Lung Cancer Diagnosis ◽

The Impact ◽

The Relationship

Introduction: The relationship between cancer and thromboembolic events has been known for a long time. Lung and venous thromboembolism are frequent complications of lung cancer and its treatment, being a great cause of morbidity and mortality. We pretend to establish the relationship between lung and venous thromboembolism and lung cancer, describe patient characteristics and analyze the impact in the survival and prognosis.Material and Methods: It was a retrospective study. All research subjects were selected from lung cancer patients with a newly diagnosed lung and venous thromboembolism event admitted to Hospital S. João, between January 2008 and December 2013 and were followed until December 2014. Statistical analysis was performed with SPSS.Results: From the search, we obtained 113 patients. The majority was male, smokers or ex-smokers, and adenocarcinoma was the most frequent histologic type, being diagnosed mostly in advanced stages. We noticed that the median time between lung cancer diagnosis and lung venous thromboembolism was 2.9 months. In 24 patients (21.4%), the lung cancer diagnosis occurred after the lung and venous thromboembolism event and in 86 patients (76.8%), it occurred before the event. After a median follow up of 1.4 months, 107 (94.7%) patients died, 1 (0.9%) was lost to follow-up and 5 (4.4%) were still alive. The median survival rate was 1.5 months.Discussion: The diagnosis of lung and venous thromboembolism in patients with lung cancer is associated with bad prognosis. It occurs most frequently in patients with advanced disease, in the first months after lung cancer diagnosis and after beginning chemotherapy.Conclusion: Disease progression is an independent predictor with negative impact in overall survival.

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The Relationship Between Psychological Flexibility, Value-Based Living and Emotional Well-Being in People Affected by Cancer

Journal of Global Oncology ◽

10.1200/jgo.18.57800 ◽

2018 ◽

Vol 4 (Supplement 2) ◽

pp. 115s-115s

Author(s):

E. Smith ◽

A. Gow ◽

L. Forsyth ◽

B. Bryne ◽

L. Howells ◽

...

Keyword(s):

Quality Of Life ◽

Cancer Diagnosis ◽

Cancer Care ◽

Psychological Flexibility ◽

Well Being ◽

Supportive Cancer Care ◽

Valued Living ◽

Being There ◽

The Relationship

Background: Receiving a cancer diagnosis can have detrimental effects on an individual's psychological flexibility (ability to adapt constructively to reality), emotional well-being and ability to live aligned with personal values, for example, in relationships and work. Higher levels of psychological flexibility and emotional well-being are associated with better quality of life and lower psychological cancer-related distress. In turn, value-based living is positively associated with psychological flexibility and emotional well-being. There is, however, limited research specifically exploring the relationship between value-based living and emotional well-being within individuals affected by cancer. Maggie's Centres ( www.maggiescentres.org ) offer an innovative, multidisciplinary model of holistic supportive cancer care, widely regarded as an exemplar of best practice in cancer rehabilitation and supported self-management. In 2017 Maggie's received 249,247 visits across the network of Centres in the UK, Hong Kong and Tokyo. Principles of ACT (acceptance and commitment therapy) are incorporated within the program of individual support, psychoeducational courses and groups to help people maximize their quality of life. Aim: To explore the associations between psychological flexibility, value-based living and emotional well-being in individuals affected by cancer. Methods: Sixty-five people, affected by a cancer diagnosis personally or in a family member, were recruited from four UK Maggie's Centres. Participants completed standardized questionnaires measuring psychological flexibility, valued-based living and emotional well-being. Results: Moderate positive associations were found between emotional well-being and psychological flexibility (r=.4750), as well as emotional well-being and valued-living (r=.37983). Psychological flexibility was also positively associated with valued living (r=.443474). Multiple regression analysis revealed a significant model (F(5,54)=9.35, P < .001), accounting for 41.4% of the variance in emotional well-being (adjusted R2 = .414). Both psychological flexibility (b=.357, P = .002) and valued-living (b=.337, P = .004) were predictors of emotional well-being across all ages, gender and time since diagnosis. Conclusion: The study provides support for the positive associations between psychological flexibility, valued-living and emotional well-being and indicates that psychological flexibility and valued-living may be predictors of emotional well-being. This was a small observational study, so conclusions about causation or change over time cannot be made. Longitudinal intervention studies need to explore the potential impact valued-living and psychological flexibility may have on emotional well-being in those affected by cancer, and so contribute to understanding the potential importance of encouraging valued-living as a therapeutic tool within cancer care.

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The association between the coronavirus disease 2019 (COVID-19) pandemic and quality of life and depression symptoms in patients with advanced lung cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.12122 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. 12122-12122

Author(s):

Lauren Heuer ◽

Kathryn Elizabeth Post ◽

Emily R. Gallagher ◽

Chardria Trotter ◽

Madeleine Elyze ◽

...

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Regression Models ◽

Advanced Lung Cancer ◽

Depression Symptoms ◽

Newly Diagnosed ◽

Cancer Symptoms ◽

Patients With Cancer ◽

The Relationship

12122 Background: It is unclear whether patients with cancer experience greater distress as a result of the COVID-19 pandemic. Thus, we assessed the relationship of the COVID-19 pandemic with quality of life (QOL) and depression symptoms in patients newly diagnosed with advanced lung cancer. Methods: We conducted a cross-sectional study of patients with advanced lung cancer enrolled in two multisite randomized supportive care trials. We enrolled adult patients within 12 weeks of diagnosis of advanced lung cancer and an Eastern Cooperative Oncology Group (ECOG) Performance Status from 0 to 3 across 23 institutions in the United States. At the time of enrollment, participants completed the Functional Assessment of Cancer Therapy-Lung (FACT-L), which includes four wellbeing subscales (i.e., physical, social, emotional, and functional) as well as lung cancer symptoms, and the Patient Health Questionnaire-9 (PHQ-9) to assess their QOL and depression symptoms, respectively. We compared QOL and depression symptoms between participants enrolled prior to COVID-19 (i.e., those enrolled in the following time periods: March 2018 to January 2019 and March 2019 to January 2020) and during the COVID-19 pandemic (March 2020 to January 2021). We used linear regression models adjusting for age, race, gender, and time since diagnosis of advanced cancer to examine the relationship between the period of enrollment and patients’ QOL and depression symptoms. Results: A total of 860 patients were included in this analysis (665 participants enrolled prior to COVID-19 and 195 participants during COVID-19). The two cohorts did not differ significantly with respect to baseline demographic factors [Mean age 65.4 (SD = 11.4), 51.9% female]. In multivariate regression models, enrollment during COVID-19 was not associated with physical (B = -0.16, SE = 0.52, P = 0.763), social (B = -0.48, SE = 0.39, P = 0.217), emotional (B = -0.16, SE = 0.41, P = 0.693), functional (B = -0.83, SE = 0.55, P = 0.128) wellbeing, or lung cancer symptoms (B = -0.11, SE = 0.44, P = 0.806). Enrollment during COVID-19 was not associated with overall QOL (FACT-L: B = -1.32, SE = 1.69, P = 0.436) or depression symptoms (PHQ-9: B = -0.02, SE = 0.45, P = 0.973). Conclusions: Despite the prevailing belief that COVID-19 has negatively impacted QOL and distress in patients with cancer, we found no differences in QOL or depression symptoms in patients newly diagnosed with advanced lung cancer during the COVID-19 pandemic compared to those diagnosed prior to the pandemic. These findings suggest that factors other than the COVID-19 pandemic, such as patients’ experience with their cancer, contribute to their QOL and depression symptoms.

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