Androstenedione synergizes with stress or prenatal drug exposure to retard fetal growth: Role of IGF

1996 ◽  
Vol 55 (4) ◽  
pp. 549-557 ◽  
Author(s):  
Robert F. McGivern ◽  
Nabil Fatayerji ◽  
Robert J. Handa
Keyword(s):  
Fetal Growth ◽  
Drug Exposure ◽  
Prenatal Drug Exposure

scholarly journals Insights into the role of placenta thickness as a predictive marker of perinatal outcome

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052199096
Author(s):  
Xiwen Sun ◽  
Jiayu Shen ◽  
Liquan Wang
Keyword(s):  
Clinical Practice ◽  
Fetal Growth ◽  
Pregnancy Outcomes ◽  
Perinatal Outcome ◽  
Predictive Marker ◽  
Fetal Abnormalities ◽  
The Relationship

The placenta is a transitory organ indispensable for normal fetal maturation and growth. Recognition of abnormal placental variants is important in clinical practice, and a broader understanding of the significance of placental variants would help clinicians better manage affected pregnancies. Increased thickness of the placenta is reported to be a nonspecific finding but it is associated with many maternal and fetal abnormalities, including preeclampsia and abnormal fetal growth. In this review, we address the questions regarding the characteristics of placenta thickness and the relationship between thickened placenta and poor pregnancy outcomes.

Pediatric Psychopharmacology and the Interaction between Drugs and the Developing Brain

1998 ◽  
Vol 43 (6) ◽  
pp. 582-584 ◽  
Author(s):  
Benedetto Vitiello
Keyword(s):  
Drug Exposure ◽  
Imaging Techniques ◽  
Quantitative Imaging ◽  
Adult Life ◽  
Prenatal Drug Exposure ◽  
Developing Brain ◽  
Teratogenic Effects ◽  
Pharmacological Agents ◽  
Early Inhibition ◽  
Interaction Between Drugs

With increasing frequency, psychotropic medications are being prescribed to young children, often for long periods of time. The interaction between psychotropics and the developing brain has not been systematically investigated in humans. Data collected from animals suggest that developing neurotransmitter systems can be exquisitely sensitive to early inhibition or stimulation by pharmacological agents, which can lead to permanent changes in adult life. Most of these data are collected from rodents, and their extrapolation to humans is difficult. More relevant models could be developed, for instance using primates. In humans, the focus of research has traditionally been on the possible teratogenic effects of prenatal drug exposure. Recently introduced quantitative imaging techniques can offer new approaches to studying the effects of psychotropics on the developing brain. This research has clear implications for the safety and efficacy of psychopharmacologic drug use in children.

The Role of Imprinted Genes in Fetal Growth

Neonatology ◽  
2002 ◽  
Vol 81 (4) ◽  
pp. 217-228 ◽  
Author(s):  
Monica Miozzo ◽  
Giuseppe Simoni
Keyword(s):  
Fetal Growth ◽  
Imprinted Genes

Intelligence and School Readiness in Preschool Children With Prenatal Drug Exposure

2004 ◽  
Vol 10 (2) ◽  
pp. 89-101 ◽  
Author(s):  
Margaret B. Pulsifer ◽  
Krestin Radonovich ◽  
Harolyn M.E. Belcher ◽  
Arlene M. Butz
Keyword(s):  
Preschool Children ◽  
School Readiness ◽  
Drug Exposure ◽  
Prenatal Drug Exposure

Monitoring pregnancy outcomes following prenatal drug exposure through prospective pregnancy registries and passive surveillance: a pharmaceutical company commitment

1998 ◽  
Vol 5 (4) ◽  
pp. 190-191 ◽  
Author(s):  
Robbin R. Eldridge ◽  
Sara A. Ephross ◽  
Cindy R. Heffner ◽  
Patricia S. Tennis ◽  
Dr.Monika Stender ◽  
...  
Keyword(s):  
Pharmaceutical Company ◽  
Pregnancy Outcomes ◽  
Drug Exposure ◽  
Prenatal Drug Exposure ◽  
Passive Surveillance

scholarly journals The Role of HLAC and NK Cells in Fetal Growth Restriction

2017 ◽  
pp. 142
Author(s):  
Sri Sulistyawati ◽  
Didon M Trimulya ◽  
Supriyadi H Respati ◽  
Soetrisno Soetrisno
Keyword(s):  
Nk Cells ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Nk Cell ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Immunohistochemical Method ◽  
Cross Sectional ◽  
The Mean

Objective: To determine the role of HLA-C and NK cell expressions in fetal growth restriction (FGR). Methods: A cross sectional study design was used. This study was conducted at the Obstetrics and Gynecology Department of Dr. Moewardi General Hospital, Surakarta, its affiliated hospitals, and at the Pathological Anatomy Laboratory of the Faculty of Medicine, University of Sebelas Maret Surakarta. A total of 40 samples were included in this study. The samples consisted of 20 normal pregnancies and 20 pregnancies with FGR. HLA-C expression in the trophoblast and NK cells in decidua of the subjects who met the inclusion and exclusion criteria were examined using immunohistochemical method and statistical analysis with T test. Results: The mean expression of HLA-C in the trophoblast in the pregnant group with FGR was 9.021.30, normal pregnancy was 7.96 ± 0.97, p=0.01 (p<0.05). The mean expression of NK cells in decidua of pregnancy with FGR was 10.59 ± 2.11, normal pregnancy was 0.91 ± 8.18, with p=0.00 (p<0.05). Conclusion: The expressions of HLA-C in trophoblast and NK cells in decidua of pregnancy with FGR were higher compared with those of normal pregnancy. [Indones J Obstet Gynecol 2017; 5-3: 142-148] Keywords: fetal growth restriction, HLA-C, NK cells

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