The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality

2009 ◽  
Vol 2009 ◽  
pp. 447-448
Author(s):  
B.H. Thiers
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Clonality ◽  
Cell Clonality

Poikilodermatous Mycosis Fungoides: Comparative Study of Clinical, Histopathological and Immunohistochemical Features

Dermatology ◽  
2019 ◽  
Vol 236 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Roberta Vasconcelos Berg ◽  
Neusa Yuriko Sakai Valente ◽  
Camilla Fanelli ◽  
Isabelle Wu ◽  
Juliana Pereira ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Clinical Presentation ◽  
Good Prognosis ◽  
High Rate ◽  
Laboratory Findings ◽  
Pityriasis Lichenoides ◽  
Presentation Methods ◽  
T Cell Clonality ◽  
Cell Clonality

Background: Poikilodermatous mycosis fungoides (pMF) is characterized by poikiloderma areas, typically involving the major flexural areas and trunk. Its presentation can be generalized or admixed with other forms of MF. Previous studies fail to correlate the clinical presentation with prognosis and laboratory findings. Some reports show pityriasis lichenoides chronica (PLC) preceding the poikiloderma. Objectives: Correlate prognostic, histopathological and molecular aspects of pMF with its clinical presentation. Methods: Retrospective analysis of 14 cases of generalized pMF (GpMF), 22 of localized pMF (LpMF) and 17 of pMF admixed with other forms of MF (mix-pMF). Results: Female predominance and lower age at diagnosis was found in all groups compared to classic MF, a high prevalence of PLC-like lesions in the GpMF group and a high rate of hypopigmented lesions in the mix-pMF group. There were 2 deaths within the GpMF group. Histology was similar to previously reported findings, as was the prevalence of CD4 T-cell infiltrate, compared to CD8. The T-cell clonality positivity was lower in the GpMF group, compared to other groups (27% GpMF, 80% LpMF and 100% mix-pMF). Discussion: This is the first article to categorize the different forms of pMF and correlate them with clinical and laboratory findings. The dermatological presentation differs among the groups. There was a high frequency of PLC-like lesions within the GpMF group and of hypopigmented lesions in mix-pMF. The histological and immunohistochemical findings were similar to those previously reported. Aggressive treatments are not recommended due to the good prognosis of all pMF forms. The low positivity of T-cell clonality in the GpMF group should be investigated.

Peripheral Blood T-Cell Clonality in Mycosis Fungoides and Nonlymphoma Controls

2003 ◽  
Vol 12 (3) ◽  
pp. 142-150 ◽  
Author(s):  
J. Marcus Muche ◽  
Wolfram Sterry ◽  
Sylke Gellrich ◽  
Berthold Rzany ◽  
Heike Audring ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Peripheral Blood ◽  
T Cell Clonality ◽  
Cell Clonality

scholarly journals T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides

2015 ◽  
Vol 73 (2) ◽  
pp. 228-236.e2 ◽  
Author(s):  
Kari E. Sufficool ◽  
Christina M. Lockwood ◽  
Haley J. Abel ◽  
Ian S. Hagemann ◽  
Jonathan A. Schumacher ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
T Cell ◽  
Mycosis Fungoides ◽  
Detection Sensitivity ◽  
Next Generation ◽  
T Cell Clonality ◽  
Generation Sequencing ◽  
Clonality Assessment ◽  
Cell Clonality

The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality

2008 ◽  
Vol 159 (4) ◽  
pp. 881-886 ◽  
Author(s):  
C. Massone ◽  
G. Crisman ◽  
H. Kerl ◽  
L. Cerroni
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Clonality ◽  
Cell Clonality

scholarly journals Peripheral Blood T Cell Clonality in Mycosis Fungoides –An Independent Prognostic Marker?

2000 ◽  
Vol 115 (3) ◽  
pp. 504-505 ◽  
Author(s):  
J. Marcus Muche ◽  
Ansgar Lukowsky ◽  
Cordula Ahnhudt ◽  
Sylke Gellrich ◽  
Wolfram Sterry
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Prognostic Marker ◽  
Peripheral Blood ◽  
Independent Prognostic Marker ◽  
T Cell Clonality ◽  
Cell Clonality

Mycosis fungoides: Topische Behandlungskonzepte ausschöpfen

2020 ◽  
Vol 8 (3) ◽  
pp. 114-116
Author(s):  
Markus Braun-Falco
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Clinical Presentation ◽  
Good Prognosis ◽  
High Rate ◽  
Laboratory Findings ◽  
Pityriasis Lichenoides ◽  
Presentation Methods ◽  
T Cell Clonality ◽  
Cell Clonality

Background: Poikilodermatous mycosis fungoides (pMF) is characterized by poikiloderma areas, typically involving the major flexural areas and trunk. Its presentation can be generalized or admixed with other forms of MF. Previous studies fail to correlate the clinical presentation with prognosis and laboratory findings. Some reports show pityriasis lichenoides chronica (PLC) preceding the poikiloderma. Objectives:Correlate prognostic, histopathological and molecular aspects of pMF with its clinical presentation. Methods: Retrospective analysis of 14 cases of generalized pMF (GpMF), 22 of localized pMF (LpMF) and 17 of pMF admixed with other forms of MF (mix-pMF). Results: Female predominance and lower age at diagnosis was found in all groups compared to classic MF, a high prevalence of PLC-like lesions in the GpMF group and a high rate of hypopigmented lesions in the mixpMF group. There were 2 deaths within the GpMF group. Histology was similar to previously reported findings, as was the prevalence of CD4 T-cell infiltrate, compared to CD8. The T-cell clonality positivity was lower in the GpMF group, compared to other groups (27% GpMF, 80% LpMF and 100% mixpMF). Discussion: This is the first article to categorize the different forms of pMF and correlate them with clinical and laboratory findings. The dermatological presentation differs among the groups. There was a high frequency of PLC-like lesions within the GpMF group and of hypopigmented lesions in mix-pMF. The histological and immunohistochemical findings were similar to those previously reported. Aggressive treatments are not recommended due to the good prognosis of all pMF forms. The low positivity of T-cell clonality in the GpMF group should be investigated.

scholarly journals Lactate dehydrogenase, Beta-2 Microglobulin Levels and CD4/CD8 Lymphocyte Ratio in Patients with Mycosis Fungoides in Stage 1A

Acta Medica ◽  
2020 ◽  
Vol 51 (4) ◽  
pp. 16-21
Author(s):  
Duygu Gülseren ◽  
Ecem Bostan ◽  
Sibel Doğan ◽  
Başak Yalıcı-Armağan ◽  
Neslihan Akdoğan ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
T Cell ◽  
Mycosis Fungoides ◽  
Peripheral Blood ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
T Cell Clonality ◽  
Cell Clonality

Objective: Mycosis fungoides is the most common type of primary cutaneous T-cell lymphomas. In this study, we aimed to investigate the biochemical parameters of beta-2 microglobulin, lactate dehydrogenase, CD4/CD8 lymphocyte ratio determined by flow cytometry, and T cell clonality in patients with MF and to correlate these parameters in stage 1A and other stages. Materials and Methods: A hundred sixty-one (87 Male, 74 Female) patients followed-up between January 1995 and January 2019 were retrospectively evaluated. Patients’ demographics, stage of the disease, peripheral lymph node and organ involvement, peripheral blood beta-2-microglobulin, lactate dehydrogenase levels, CD4/CD8 + lymphocyte ratio and presence of T cell clonality in biopsy samples were evaluated. Results: Median beta-2 microglobulin levels were 1608.5 ng/ml for stage 1A and 1970.5 ng/ml for other stages. Peripheral blood median CD4/CD8 lymphocte ratio was 1.60 for stage 1A and 1.85 for other stages. We found statistically significant difference between two groups in terms of beta-2 microglobulin levels and peripheral blood median CD4/CD8 lymphocte ratio (p=0.001, p=0.04). No statistically significant difference was found between two groups in terms of lactate dehydrogenase levels and T-cell clonality (p=0.234, p=0.525). Conclusion: Our study supports that high peripheral blood beta-2 microglobulin level and CD4/CD8 lymphocyte ratio at the time of diagnosis may imply advanced stage and poor prognosis in Mycosis Fungoides.

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