Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data

The Lancet ◽  
2000 ◽  
Vol 355 (9208) ◽  
pp. 949-955 ◽  
Author(s):  
JP Pignon ◽  
J Bourhis ◽  
C Domenge ◽  
L Designé
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Individual Data ◽  
Locoregional Treatment ◽  
Meta Analyses

scholarly journals Prospective Evaluation of XRCC-1 as a Biopredictor for Survival Outcomes in Patients of Head and Neck Squamous Cell Carcinoma (HNSCC): A Meta-analysis

2021 ◽  
Author(s):  
Fan Yang ◽  
Liu-qing Zhou ◽  
Yan-jun Wang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Neck Squamous Cell Carcinoma ◽  
Survival Outcomes ◽  
Prognostic Impact ◽  
Meta Analyses

Abstract Background: Epidemiologic studies have demonstrated that X-ray repair cross-complementary group 1 (XRCC1) is one of the susceptibility factors in head and neck squamous cell carcinoma(HNSCC) patients. However, its clinical prognostic impact remains controversial. Thus, a meta-analysis was performed to clarify the survival value of XRCC1 in HNSCC patients.Methods: Following the Preferred Reporting Items or Systematic Reviews Meta Analyses (PRISMA) 2020 guidelines, literature searches were systematically performed by PubMed, EMBASE and Web of Science with a manual retreive to evaluate the prognostic consequence of XRCC1 in HNSCC patients. Hazard ratios (HRs) and 95% confidence intervals (CIs) were collected to estimate the correlation between XRCC1 and the survival outcomes of HNSCC patients.Results: Ten studies including 2086 HNSCC patients who satisfied the inclusion and exclusion criteria were included in this meta-analysis. The meta-analysis showed that high XRCC1 expression and Arg399Gln and Arg194Trp were significantly correlated with poorer overall survival (OS), with HRs of 1.97 (95% CI, 1.36–2.84, P<0.001), 1.30 (95% CI, 1.12–1.51, P<0.001), and 1.65 (95% CI, 1.18–2.32 P<0.05), respectively.Conclusion: XRCC1 was associated with poorer survival outcomes in HNSCC patients. Hence, XRCC1 is a potential therapeutic target for HNSCC.

Natural history following recurrence after definitive locoregional treatment in 1000+ cases of locally advanced head and neck squamous cell carcinoma.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 6062-6062 ◽  
Author(s):  
Jonathan Eric Leeman ◽  
Jin-Gao Li ◽  
Praveen Venigalla ◽  
Zachary Stephan Zumsteg ◽  
Sean Matthew McBride ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Natural History ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Neck Squamous Cell Carcinoma ◽  
Advanced Head ◽  
Locoregional Treatment

scholarly journals p53 Mutation and Locoregional Treatment Failure in Head and Neck Squamous Cell Carcinoma

1996 ◽  
Vol 88 (21) ◽  
pp. 1580-1586 ◽  
Author(s):  
W. M. Koch ◽  
J. A. Brennan ◽  
M. Zahurak ◽  
S. N. Goodman ◽  
W. H. Westra ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Treatment Failure ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
P53 Mutation ◽  
Neck Squamous Cell Carcinoma ◽  
Locoregional Treatment
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