UNICELLULAR SEBACEOUS GLANDS IN THE BASAL LAYER OF THE NORMAL HUMAN EPIDERMIS

The Lancet ◽  
1951 ◽  
Vol 257 (6660) ◽  
pp. 888-889 ◽  
Author(s):  
E WOLFF
Keyword(s):  
Basal Layer ◽  
Human Epidermis ◽  
Sebaceous Glands ◽  
Normal Human

Collagenolytic-like activity of normal human epidermis

1971 ◽  
Vol 242 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Kays H. Kaidbey ◽  
Amal K. Kurban ◽  
Krikor Tenekjian
Keyword(s):  
Human Epidermis ◽  
Normal Human

scholarly journals 272 Understanding cell heterogeneity in the basal layer of human epidermis

2019 ◽  
Vol 139 (9) ◽  
pp. S261
Author(s):  
D. Belokhvostova ◽  
C. Philippeos ◽  
L. Mamanova ◽  
C. Smith ◽  
M. Haniffa ◽  
...  
Keyword(s):  
Basal Layer ◽  
Human Epidermis ◽  
Cell Heterogeneity

Localization and Characterization of the Interleukin 1 Immunoreactive Pool (IL-1 alpha and beta Forms) in Normal Human Epidermis

1989 ◽  
Vol 92 (6) ◽  
pp. 809-816 ◽  
Author(s):  
Liliane Didierjean ◽  
Denis Salomon ◽  
Yves Mérot ◽  
Georges Siegenthaler ◽  
Jean-Hilaire Saurat ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Human Epidermis ◽  
Normal Human

scholarly journals The Epidermal Stem Cell Compartment: Variation in Expression Levels of E–Cadherin and Catenins Within the Basal Layer of Human Epidermis

1997 ◽  
Vol 45 (6) ◽  
pp. 867-874 ◽  
Author(s):  
Jean-Pierre Molès ◽  
Fiona M. Watt
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Basal Layer ◽  
Human Epidermis ◽  
Proliferative Potential ◽  
Stem Cell Markers ◽  
Cell Compartment ◽  
Stem Cell Compartment ◽  
E Cadherin ◽  
Cell Cell

The basal layer of the epidermis contains two types of proliferating keratinocyte: stem cells, with high proliferative potential, and transit amplifying cells, which are destined to undergo terminal differentiation after a few rounds of division. It has been shown previously that two- to three-fold differences in the average staining intensity of fluorescein-conjugated antibodies to β1 integrin subunits reflect profound differences in the proliferative potential of keratinocytes, with integrin-bright populations being enriched for stem cells. In the search for additional stem cell markers, we have stained sections of normal human epidermis with antibodies to proteins involved in intercellular adhesion and quantitated the fluorescence of individual cell-cell borders. In the basal layer, patches of brightly labeled cells were detected with antibodies to E-cadherin, β-catenin, and γ-catenin, but not with antibodies to P-cadherin, α-catenin, or with pan-desmocollin and pan-desmoglein antibodies. In the body sites examined, palm and foreskin, integrinbright regions were strongly labeled for γ-catenin and weakly labeled for E-cadherin and β-catenin. Our data suggest that there are gradients of both cell-cell and cell-extracellular matrix adhesiveness within the epidermal basal layer and that the levels of E-cadherin and of β-and γ-catenin may provide markers for the stem cell compartment, stem cells expressing relatively higher levels of γ-catenin and lower levels of E-cadherin and β-catenin than other basal keratinocytes.

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